NPM1

NPM1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2LLH, 2P1B, 2VXD
معین‌کننده‌ها
نام‌های دیگر	NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1
شناسه‌های بیرونی	OMIM: 164040 MGI: 106184 HomoloGene: 81697 GeneCards: NPM1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	33,113,206 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• ribosomal large subunit binding; • protein homodimerization activity; • ribosomal small subunit binding; • unfolded protein binding; • GO:0001105 transcription coactivator activity; • protein kinase inhibitor activity; • GO:0031493 histone binding; • Tat protein binding; • NF-kappaB binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • RNA binding; • protein heterodimerization activity; • nucleic acid binding; • protein kinase binding; • transcription factor binding; • rRNA binding; • protein N-terminus binding; • chromatin binding;
ترکیبات سلولی	• سیتوپلاسم; • membrane; • focal adhesion; • spindle pole centrosome; • نوکلئوپلاسم; • microtubule organizing center; • هستک; • اسکلت سلولی; • هسته یاخته; • protein-DNA complex; • granular component; • میان‌تن; • سیتوزول; • large ribosomal subunit; • small ribosomal subunit; • nuclear speck; • GO:0009327 protein-containing complex; • ribonucleoprotein complex;
فرایند زیستی	• centrosome cycle; • regulation of eIF2 alpha phosphorylation by dsRNA; • positive regulation of cell cycle G2/M phase transition; • negative regulation of centrosome duplication; • regulation of centriole replication; • response to stress; • positive regulation of translation; • GO:0061641 CENP-A containing chromatin assembly; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of NF-kappaB transcription factor activity; • protein complex oligomerization; • negative regulation of protein kinase activity by regulation of protein phosphorylation; • regulation of endodeoxyribonuclease activity; • regulation of endoribonuclease activity; • ribosome assembly; • intracellular protein transport; • GO:0100026 بازسازی دی‌ان‌ای; • GO:0072468 ورارسانی پیام; • negative regulation of cell population proliferation; • nucleosome assembly; • GO:0022415 viral process; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • cellular response to UV; • ribosomal large subunit export from nucleus; • ribosomal small subunit export from nucleus; • rRNA export from nucleus; • cell volume homeostasis; • nucleocytoplasmic transport; • GO:0034613 protein localization; • positive regulation of cell population proliferation; • posttranscriptional regulation of gene expression; • negative regulation of gene expression; • regulation of centrosome duplication; • positive regulation of centrosome duplication; • رشد یاخته; • positive regulation of cellular biosynthetic process; • positive regulation of protein ubiquitination; • regulation of protein stability; • ribosomal large subunit biogenesis; • ribosomal small subunit biogenesis; • negative regulation of apoptotic process; • regulation of DNA damage response, signal transduction by p53 class mediator; • positive regulation of protein kinase activity; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of mRNA splicing, via spliceosome; • protein stabilization; • protein homooligomerization; • regulation of cell cycle; • positive regulation of protein localization to nucleolus; • chromatin remodeling; • regulation of mRNA stability involved in cellular response to UV;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4869
	18148
	ENSG00000181163
	ENSMUSG00000057113
	P06748
	Q61937
	NM_002520، NM_199185، NM_001355006، NM_001355009، NR_149149، NM_001355007، NM_001355010 NM_001037738، NM_002520، NM_199185، NM_001355006، NM_001355009، NR_149149، NM_001355007، NM_001355010
	NM_001252261، NM_008722، XR_003949348 NM_001252260، NM_001252261، NM_008722، XR_003949348
	NP_002511، NP_954654، NP_001341935، NP_001341938، NP_001341936، NP_001341939 NP_001032827، NP_002511، NP_954654، NP_001341935، NP_001341938، NP_001341936، NP_001341939
	NP_001239190، NP_032748 NP_001239189، NP_001239190، NP_032748
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

نوکلئوفُسمین (انگلیسی: Nucleophosmin) یک پروتئین است که در انسان توسط ژن «NPM1» کُدگذاری می‌شود.^[۴]^[۵]

این مولکول در درون هستک جای دارد و با ریبونوکلئوپروتئین آن در ارتباط است و به اسید نوکلئیک‌های تک‌رشته‌ای و دورشته‌ای متصل می‌شود.

وظایف نوکلئوفُسمین به شرح زیر است:^[۶]

شپرون هیستون‌ها
ساخت ریبوزوم و انتقال آنها
پایداری ژنتیکی و ترمیم دی‌ان‌ای
تقسیم سانتروزوم حین چرخهٔ سلول
تنظیم مسیر ARF-p53 در سرکوب تومور
فعالیت ناپایدارسازی مارپیچ آران‌ای
مهار کردن آنزیم دی‌ان‌آی‌آز فعال‌شده توسط کاسپاز
جلوگیری از آپوپتوز در درون هستک

اهمیت بالینی[ویرایش]

ژن «NPM1» در برخی انواع سرطان‌ها دچار جهش، جابجایی جایگاه کروموزومی یا افزایش تولید می‌شود که از آن میان می‌توان به لنفوم غیرهاجکین، لوسمی پرومیلوسیتیک حاد، سندرم میلودیسپلاستیک و لوسمی حاد مغز استخوان (AML)^[۷] اشاره کرد.^[۸]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000057113 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liu QR, Chan PK (March 1993). "Characterization of seven processed pseudogenes of nucleophosmin/B23 in the human genome". DNA and Cell Biology. 12 (2): 149–56. doi:10.1089/dna.1993.12.149. PMID 8471164.
↑ Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–4. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.
↑ Lindström MS (2011). "NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling". Biochemistry Research International. 2011: 1–16. doi:10.1155/2011/195209. PMC 2989734. PMID 21152184.
↑ Meani N, Alcalay M (September 2009). "Role of nucleophosmin in acute myeloid leukemia". Expert Review of Anticancer Therapy. 9 (9): 1283–94. doi:10.1586/era.09.84. PMID 19761432.
↑ Falini B, Nicoletti I, Bolli N, Martelli MP, Liso A, Gorello P, Mandelli F, Mecucci C, Martelli MF (April 2007). "Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias" (PDF). Haematologica. 92 (4): 519–32. doi:10.3324/haematol.11007. PMID 17488663.

مشارکت‌کنندگان ویکی‌پدیا. «NPM1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر[ویرایش]

Yun C, Wang Y, Mukhopadhyay D, Backlund P, Kolli N, Yergey A, Wilkinson KD, Dasso M (November 2008). "Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases". The Journal of Cell Biology. 183 (4): 589–95. doi:10.1083/jcb.200807185. PMC 2582899. PMID 19015314.
Haindl M, Harasim T, Eick D, Muller S (March 2008). "The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing". EMBO Reports. 9 (3): 273–9. doi:10.1038/embor.2008.3. PMC 2267381. PMID 18259216.
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Gjerset RA (September 2006). "DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer". Journal of Molecular Histology. 37 (5–7): 239–51. doi:10.1007/s10735-006-9040-y. PMID 16855788.
Chen W, Rassidakis GZ, Medeiros LJ (November 2006). "Nucleophosmin gene mutations in acute myeloid leukemia". Archives of Pathology & Laboratory Medicine. 130 (11): 1687–92. doi:10.1043/1543-2165(2006)130[1687:NGMIAM]2.0.CO;2 (inactive 2020-01-22). PMID 17076533.{{cite journal}}: CS1 maint: DOI inactive as of ژانویه 2020 (link)
Falini B, Nicoletti I, Bolli N, Martelli MP, Liso A, Gorello P, Mandelli F, Mecucci C, Martelli MF (April 2007). "Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias" (PDF). Haematologica. 92 (4): 519–32. doi:10.3324/haematol.11007. PMID 17488663.
Fankhauser C, Izaurralde E, Adachi Y, Wingfield P, Laemmli UK (May 1991). "Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element". Molecular and Cellular Biology. 11 (5): 2567–75. doi:10.1128/MCB.11.5.2567. PMC 360026. PMID 2017166.
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[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000057113 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_8471164-4] Liu QR, Chan PK (March 1993). "Characterization of seven processed pseudogenes of nucleophosmin/B23 in the human genome". DNA and Cell Biology. 12 (2): 149–56. doi:10.1089/dna.1993.12.149. PMID 8471164.

[pmid_8122112-5] Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–4. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.

[pmid_21152184-6] Lindström MS (2011). "NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling". Biochemistry Research International. 2011: 1–16. doi:10.1155/2011/195209. PMC 2989734. PMID 21152184.

[MeaniAlcalay2014-7] Meani N, Alcalay M (September 2009). "Role of nucleophosmin in acute myeloid leukemia". Expert Review of Anticancer Therapy. 9 (9): 1283–94. doi:10.1586/era.09.84. PMID 19761432.

[pmid_17488663-8] Falini B, Nicoletti I, Bolli N, Martelli MP, Liso A, Gorello P, Mandelli F, Mecucci C, Martelli MF (April 2007). "Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias" (PDF). Haematologica. 92 (4): 519–32. doi:10.3324/haematol.11007. PMID 17488663.

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