اینتگرین آلفا ۴

ITGA4
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4HKC, 3V4P, 3V4V, 5FPI, 5C7Z
معین‌کننده‌ها
نام‌های دیگر	ITGA4, CD49D, IA4, integrin subunit alpha 4
شناسه‌های بیرونی	OMIM: 192975 MGI: 96603 HomoloGene: 37364 GeneCards: ITGA4
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	79,163,467 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • protein antigen binding; • metal ion binding; • GO:0003823، GO:0051635 antigen binding; • fibronectin binding; • cell adhesion molecule binding; • coreceptor activity; • C-X3-C chemokine binding; • protein heterodimerization activity;
ترکیبات سلولی	• extracellular exosome; • integral component of membrane; • membrane; • focal adhesion; • cell surface; • integrin alpha4-beta7 complex; • integrin complex; • پوسته یاخته; • growth cone; • neuronal cell body; • GO:0009327 protein-containing complex;
فرایند زیستی	• endodermal cell differentiation; • B cell differentiation; • positive regulation of T cell migration; • extracellular matrix organization; • heterotypic cell-cell adhesion; • substrate adhesion-dependent cell spreading; • cellular response to cytokine stimulus; • cell-matrix adhesion involved in ameboidal cell migration; • cell-matrix adhesion; • leukocyte tethering or rolling; • دیاپدز; • regulation of immune response; • integrin-mediated signaling pathway; • leukocyte migration; • positive regulation of leukocyte tethering or rolling; • positive regulation of leukocyte cell-cell adhesion; • positive regulation of leukocyte migration; • import into cell; • leukocyte cell-cell adhesion; • negative regulation of protein homodimerization activity; • clathrin-dependent extracellular exosome endocytosis; • چسبندگی سلولی; • receptor clustering; • cell-cell adhesion mediated by integrin; • axonogenesis involved in innervation; • cell-cell adhesion in response to extracellular stimulus; • cellular response to amyloid-beta; • positive regulation of vascular endothelial cell proliferation; • neuron projection extension; • positive regulation of endothelial cell apoptotic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3676
	16401
	ENSG00000115232
	ENSMUSG00000027009
	P13612
	Q00651
	NM_001316312 NM_000885، NM_001316312
	XM_036158647 NM_010576، XM_036158647
	NP_001303241 NP_000876، NP_001303241
	XP_036014540 NP_034706، XP_036014540
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اینتگرین آلفا ۴ (انگلیسی: Integrin alpha 4) نوعی پروتئین و همچنین زیرواحد آلفای اینتگرین است که نیمی از گیرندهٔ لنفوسیتی α4β1 را تشکیل می‌دهد.

زنجیرهٔ آلفا ۴ اینتگرین با «زنجیرهٔ بتا ۱» یا «زنجیرهٔ بتا ۷» از ارتباط است^[۴] و با گالکتین-۸^[۵] و پاکسیلین^[۶]^[۷] تعامل پروتئین-پروتئین دارد.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027009 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)".
↑ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (Pt 13): 2385–97. PMID 10852818.
↑ Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025.
↑ Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182.

مشارکت‌کنندگان ویکی‌پدیا. «Integrin alpha 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

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پیوند به بیرون

CD49d antigen در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027009 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)".

[pmid10852818-5] Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (Pt 13): 2385–97. PMID 10852818.

[pmid11533025-6] Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025.

[pmid11919182-7] Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182.

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