اینتگرین بتا ۱

ITGB1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4WK4, 3G9W, 3T9K, 3VI3, 3VI4, 4DX9, 4WJK, 4WK0, 4WK2
معین‌کننده‌ها
نام‌های دیگر	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
شناسه‌های بیرونی	OMIM: 135630 MGI: 96610 HomoloGene: 22999 GeneCards: ITGB1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۸ (موش)
پایان	129,459,681 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• virus receptor activity; • metal ion binding; • integrin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • laminin binding; • cell adhesion molecule binding; • collagen binding involved in cell-matrix adhesion; • coreceptor activity; • protease binding; • fibronectin binding; • actin binding; • C-X3-C chemokine binding; • protein heterodimerization activity; • GO:0032403 protein-containing complex binding; • cadherin binding; • signaling receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • اندوزوم; • membrane; • melanosome; • ruffle; • integrin alpha8-beta1 complex; • سیناپس; • ruffle membrane; • integrin complex; • perinuclear region of cytoplasm; • cell projection; • dendritic spine; • cell surface; • cleavage furrow; • integrin alpha7-beta1 complex; • extracellular exosome; • پای‌لایه; • integral component of membrane; • recycling endosome; • integrin alpha1-beta1 complex; • صفحات بینابینی; • filopodium; • تماس عصبی-ماهیچه‌ای; • receptor complex; • پوسته یاخته; • integrin alpha11-beta1 complex; • myelin sheath abaxonal region; • synaptic membrane; • integrin alpha10-beta1 complex; • پیوند میان‌یاخته‌ای; • integrin alpha2-beta1 complex; • سارکولما; • external side of plasma membrane; • GO:0016023 cytoplasmic vesicle; • integrin alpha3-beta1 complex; • لیپید رفت; • focal adhesion; • glial cell projection; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • integral component of synaptic membrane; • GO:0009327 protein-containing complex;
فرایند زیستی	• leukocyte cell-cell adhesion; • cell migration involved in sprouting angiogenesis; • stress fiber assembly; • ورود ویروس; • B cell differentiation; • neuron projection development; • transforming growth factor beta receptor signaling pathway; • regulation of collagen catabolic process; • negative regulation of cell differentiation; • cardiac muscle cell differentiation; • cellular response to low-density lipoprotein particle stimulus; • in utero embryonic development; • cell-substrate adhesion; • GO:0032320، GO:0032321، GO:0032855، GO:0043089، GO:0032854 positive regulation of GTPase activity; • regulation of immune response; • GO:0022415 viral process; • dendrite morphogenesis; • cell fate specification; • گام نخستین رشد; • heterotypic cell-cell adhesion; • extracellular matrix organization; • cell-cell adhesion mediated by integrin; • cellular defense response; • چسبندگی سلولی; • formation of radial glial scaffolds; • axon extension; • leukocyte tethering or rolling; • integrin-mediated signaling pathway; • cell-matrix adhesion; • sarcomere organization; • negative regulation of anoikis; • leukocyte migration; • homophilic cell adhesion via plasma membrane adhesion molecules; • یادگیری بصری; • calcium-independent cell-matrix adhesion; • cardiac muscle tissue development; • negative regulation of Rho protein signal transduction; • receptor internalization; • regulation of cell cycle; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • mesodermal cell differentiation; • کوچ یاخته; • germ cell migration; • cell adhesion mediated by integrin; • basement membrane organization; • positive regulation of protein localization to plasma membrane; • G1/S transition of mitotic cell cycle; • بیگانه‌خواری; • cytokine-mediated signaling pathway; • cell projection organization; • lamellipodium assembly; • positive regulation of angiogenesis; • modulation of chemical synaptic transmission; • positive regulation of protein kinase B signaling; • positive regulation of signaling receptor activity; • positive regulation of cell migration;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3688
	16412
	ENSG00000150093
	ENSMUSG00000025809
	P05556
	P09055
	NM_033666، NM_033667، NM_033668، NM_033669، NM_133376 NM_002211، NM_033666، NM_033667، NM_033668، NM_033669، NM_133376
	NM_010578
	NP_391988، NP_596867 NP_002202، NP_391988، NP_596867
	NP_034708
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اینتگرین بتا ۱ (انگلیسی: Integrin beta 1) که با نام CD29 هم شناخته می‌شود، یکی از گیرنده‌های سطح سلول است که در انسان توسط ژن «ITGB1» کُدگذاری می‌شود.^[۴] این پروتئین به اینتگرین آلفا ۲ اتصال یافته و ترکیب ساختاری اینتگرین را می‌سازند که به‌عنوان گیرنده کلاژن عمل می‌کند. همچنین به اینتگرین آلفا ۳ متصل شده و در نقشِ گیرنده‌های اینتگرینی برای نترین ۱ و ریلین ظاهر می‌شود.

اهمیت بالینی[ویرایش]

در بیماران مبتلا به دیستروفی ماهیچه‌ای کمربند اندام اینتگرین‌های نوع 2C و beta-1D به‌شدت در ماهیچه‌های اسکلتی کاهش یافته‌است که با کاهش اینتگرین آلفا ۷ و فیلامین ۲ مطابقت دارد.^[۵]

در مبتلایان به «پلی‌نورپاتی حساس حرکتی» سطح «اینتگرین آلفا ۷ بی» و «اینتگرین بتا ۱ دی» کاهش شدید داشته تا آنجایی که دیگر قابل ردیابی نیست و این موضوع با کاهش سطح آران‌ای پیام‌رسان مطابقت دارد.^[۶]

فعل و انفعالات[ویرایش]

CD29 با پروتئین های زیر تعامل پروتئین-پروتئین دارد:

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN (Jan 1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Annals of Human Genetics. 53 (Pt 1): 15–22. doi:10.1111/j.1469-1809.1989.tb01118.x. PMID 2524991.
↑ Anastasi G, Cutroneo G, Trimarchi F, Santoro G, Bruschetta D, Bramanti P, Pisani A, Favaloro A (Dec 2004). "Evaluation of sarcoglycans, vinculin-talin-integrin system and filamin2 in alpha- and gamma-sarcoglycanopathy: an immunohistochemical study". International Journal of Molecular Medicine. 14 (6): 989–99. doi:10.3892/ijmm.14.6.989. PMID 15547664.
↑ Anastasi G, Cutroneo G, Santoro G, Arco A, Rizzo G, Bramanti P, Rinaldi C, Sidoti A, Amato A, Favaloro A (Sep 2008). "Costameric proteins in human skeletal muscle during muscular inactivity". Journal of Anatomy. 213 (3): 284–95. doi:10.1111/j.1469-7580.2008.00921.x. PMC 2732038. PMID 18537849.
↑ Otey CA, Pavalko FM, Burridge K (Aug 1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". The Journal of Cell Biology. 111 (2): 721–9. doi:10.1083/jcb.111.2.721. PMC 2116186. PMID 2116421.
↑ Otey CA, Vasquez GB, Burridge K, Erickson BW (Oct 1993). "Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain". The Journal of Biological Chemistry. 268 (28): 21193–7. doi:10.1016/S0021-9258(19)36909-1. PMID 7691808.
↑ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (Mar 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". European Journal of Immunology. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.
↑ Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochemical and Biophysical Research Communications. 222 (1): 13–8. doi:10.1006/bbrc.1996.0690. PMID 8630057.
↑ ^۱۱٫۰ ^۱۱٫۱ Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M (Sep 2002). "Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration". Journal of Hepatology. 37 (3): 322–30. doi:10.1016/S0168-8278(02)00175-7. PMID 12175627.
↑ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". The Journal of Biological Chemistry. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
↑ ^۱۳٫۰ ^۱۳٫۱ van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A (Jan 2002). "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits". The Journal of Cell Biology. 156 (2): 361–76. doi:10.1083/jcb.200103037. PMC 2199218. PMID 11807098.
↑ Loo DT, Kanner SB, Aruffo A (Sep 1998). "Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction". The Journal of Biological Chemistry. 273 (36): 23304–12. doi:10.1074/jbc.273.36.23304. PMID 9722563.
↑ Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
↑ ^۱۶٫۰ ^۱۶٫۱ Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM (Nov 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthritis and Cartilage. 10 (11): 890–7. doi:10.1053/joca.2002.0842. PMID 12435334.
↑ Liliental J, Chang DD (Jan 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". The Journal of Biological Chemistry. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
↑ Chang DD, Wong C, Smith H, Liu J (Sep 1997). "ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin". The Journal of Cell Biology. 138 (5): 1149–57. doi:10.1083/jcb.138.5.1149. PMC 2136751. PMID 9281591.
↑ Chang DD, Hoang BQ, Liu J, Springer TA (Mar 2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". The Journal of Biological Chemistry. 277 (10): 8140–5. doi:10.1074/jbc.M109031200. PMID 11741908.
↑ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". Journal of Cell Science. 113 (13): 2385–97. doi:10.1242/jcs.113.13.2385. PMID 10852818.
↑ Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E (Apr 2002). "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans". Current Biology. 12 (8): 622–31. doi:10.1016/S0960-9822(02)00764-9. PMID 11967148. S2CID 9977605.
↑ Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C (Jun 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". The Journal of Biological Chemistry. 277 (23): 20895–902. doi:10.1074/jbc.M200200200. PMID 11919189.
↑ Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T (Aug 2002). "Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis". Molecular and Cellular Biology. 22 (16): 5897–911. doi:10.1128/MCB.22.16.5897-5911.2002. PMC 133968. PMID 12138200.
↑ Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L (Mar 1989). "Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts". Oncogene. 4 (3): 325–33. PMID 2468126.
↑ Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K (1986). "Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage". Nature. 320 (6062): 531–3. Bibcode:1986Natur.320..531H. doi:10.1038/320531a0. PMID 2938015. S2CID 4356748.
↑ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Nov 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
↑ Han DC, Rodriguez LG, Guan JL (Jan 2001). "Identification of a novel interaction between integrin beta1 and 14-3-3beta". Oncogene. 20 (3): 346–57. doi:10.1038/sj.onc.1204068. PMID 11313964.

مشارکت‌کنندگان ویکی‌پدیا. «Integrin beta 1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

Evans JP (Jul 2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
Armulik A (Jan 2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions". Frontiers in Bioscience. 7: d219-27. doi:10.2741/armulik. PMID 11779688.
Brakebusch C, Fässler R (Sep 2005). "beta 1 integrin function in vivo: adhesion, migration and more". Cancer Metastasis Reviews. 24 (3): 403–11. doi:10.1007/s10555-005-5132-5. PMID 16258728.

پیوند به بیرون[ویرایش]

CD29 Antigen در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم ITGB1 انسانی و صفحهٔ جزئیات ژنی ITGB1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_2524991-4] Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN (Jan 1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Annals of Human Genetics. 53 (Pt 1): 15–22. doi:10.1111/j.1469-1809.1989.tb01118.x. PMID 2524991.

[5] Anastasi G, Cutroneo G, Trimarchi F, Santoro G, Bruschetta D, Bramanti P, Pisani A, Favaloro A (Dec 2004). "Evaluation of sarcoglycans, vinculin-talin-integrin system and filamin2 in alpha- and gamma-sarcoglycanopathy: an immunohistochemical study". International Journal of Molecular Medicine. 14 (6): 989–99. doi:10.3892/ijmm.14.6.989. PMID 15547664.

[6] Anastasi G, Cutroneo G, Santoro G, Arco A, Rizzo G, Bramanti P, Rinaldi C, Sidoti A, Amato A, Favaloro A (Sep 2008). "Costameric proteins in human skeletal muscle during muscular inactivity". Journal of Anatomy. 213 (3): 284–95. doi:10.1111/j.1469-7580.2008.00921.x. PMC 2732038. PMID 18537849.

[7] Otey CA, Pavalko FM, Burridge K (Aug 1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". The Journal of Cell Biology. 111 (2): 721–9. doi:10.1083/jcb.111.2.721. PMC 2116186. PMID 2116421.

[8] Otey CA, Vasquez GB, Burridge K, Erickson BW (Oct 1993). "Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain". The Journal of Biological Chemistry. 268 (28): 21193–7. doi:10.1016/S0021-9258(19)36909-1. PMID 7691808.

[pmid10741407-9] Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (Mar 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". European Journal of Immunology. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

[pmid8630057-10] Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochemical and Biophysical Research Communications. 222 (1): 13–8. doi:10.1006/bbrc.1996.0690. PMID 8630057.

[pmid12175627-11] ۱۱٫۰ ^۱۱٫۱ Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M (Sep 2002). "Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration". Journal of Hepatology. 37 (3): 322–30. doi:10.1016/S0168-8278(02)00175-7. PMID 12175627.

[pmid10906324-12] Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". The Journal of Biological Chemistry. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.

[pmid11807098-13] ۱۳٫۰ ^۱۳٫۱ van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A (Jan 2002). "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits". The Journal of Cell Biology. 156 (2): 361–76. doi:10.1083/jcb.200103037. PMC 2199218. PMID 11807098.

[pmid9722563-14] Loo DT, Kanner SB, Aruffo A (Sep 1998). "Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction". The Journal of Biological Chemistry. 273 (36): 23304–12. doi:10.1074/jbc.273.36.23304. PMID 9722563.

[pmid10229664-15] Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.

[pmid12435334-16] ۱۶٫۰ ^۱۶٫۱ Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM (Nov 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthritis and Cartilage. 10 (11): 890–7. doi:10.1053/joca.2002.0842. PMID 12435334.

[pmid9442085-17] Liliental J, Chang DD (Jan 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". The Journal of Biological Chemistry. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.

[pmid9281591-18] Chang DD, Wong C, Smith H, Liu J (Sep 1997). "ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin". The Journal of Cell Biology. 138 (5): 1149–57. doi:10.1083/jcb.138.5.1149. PMC 2136751. PMID 9281591.

[pmid11741908-19] Chang DD, Hoang BQ, Liu J, Springer TA (Mar 2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". The Journal of Biological Chemistry. 277 (10): 8140–5. doi:10.1074/jbc.M109031200. PMID 11741908.

[pmid10852818-20] Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". Journal of Cell Science. 113 (13): 2385–97. doi:10.1242/jcs.113.13.2385. PMID 10852818.

[pmid11967148-21] Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E (Apr 2002). "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans". Current Biology. 12 (8): 622–31. doi:10.1016/S0960-9822(02)00764-9. PMID 11967148. S2CID 9977605.

[pmid11919189-22] Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C (Jun 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". The Journal of Biological Chemistry. 277 (23): 20895–902. doi:10.1074/jbc.M200200200. PMID 11919189.

[pmid12138200-23] Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T (Aug 2002). "Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis". Molecular and Cellular Biology. 22 (16): 5897–911. doi:10.1128/MCB.22.16.5897-5911.2002. PMC 133968. PMID 12138200.

[24] Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L (Mar 1989). "Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts". Oncogene. 4 (3): 325–33. PMID 2468126.

[25] Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K (1986). "Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage". Nature. 320 (6062): 531–3. Bibcode:1986Natur.320..531H. doi:10.1038/320531a0. PMID 2938015. S2CID 4356748.

[pmid9360996-26] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Nov 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

[pmid11313964-27] Han DC, Rodriguez LG, Guan JL (Jan 2001). "Identification of a novel interaction between integrin beta1 and 14-3-3beta". Oncogene. 20 (3): 346–57. doi:10.1038/sj.onc.1204068. PMID 11313964.

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