ایمیدازوتیازول‌ها

ایمیدازوتیازول‌ها دسته ای از ترکیبات شیمیایی حاوی یک هتروسیکل دو حلقه ای (یک سیستم آروماتیک دو حلقه‌ای) هستند که از یک حلقه ایمیدازول و یک حلقه تیازول که به هم جوش خورده‌اند، تشکیل شده‌است.^[۱] این ساختار شامل سه اتم غیر کربن یا هترواتم است که عبارت‌اند از: دو اتم نیتروژن و یک اتم گوگرد. مشتقات ایمیدازوتیازول در آزمایشات in vitro طیف گسترده‌ای از فعالیت‌های زیستی، مانند خاصیت ضد سرطانی،^[۲]^[۳]^[۴] ضد روان‌پریشی،^[۵] ضد میکروبی،^[۶] ضد قارچی،^[۷] و ضد کرم^[۸] را نشان می‌دهند.

منابع[ویرایش]

↑ Fascio, Mirta L.; Errea, María Inés; D'Accorso, Norma Beatriz (2015-01-27). "Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties". European Journal of Medicinal Chemistry (به انگلیسی). 90: 666–683. doi:10.1016/j.ejmech.2014.12.012. PMID 25499987.
↑ Gürsoy, Elif; Güzeldemirci, Nuray Ulusoy (2007-03-01). "Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives". European Journal of Medicinal Chemistry (به انگلیسی). 42 (3): 320–326. doi:10.1016/j.ejmech.2006.10.012. PMID 17145120.
↑ Andreani, Aldo; Granaiola, Massimiliano; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Varoli, Lucilla; Lannigan, Deborah; Smith, Jeff (2011-09-01). "Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors [1]". European Journal of Medicinal Chemistry (به انگلیسی). 46 (9): 4311–4323. doi:10.1016/j.ejmech.2011.07.001. PMID 21794960. {{cite journal}}: |hdl-access= requires |hdl= (help)
↑ Park, Jin-Hun; El-Gamal, Mohammed I.; Lee, Yong Sup; Oh, Chang-Hyun (2011-12-01). "New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies". European Journal of Medicinal Chemistry (به انگلیسی). 46 (12): 5769–5777. doi:10.1016/j.ejmech.2011.08.024. PMID 22033063.
↑ Cole, Derek C.; Stock, Joseph R.; Lennox, William J.; Bernotas, Ronald C.; Ellingboe, John W.; Boikess, Steve; Coupet, Joseph; Smith, Deborah L.; Leung, Louis (2007-11-01). "Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist". Journal of Medicinal Chemistry. 50 (23): 5535–5538. doi:10.1021/jm070521y. PMID 17948978.
↑ Güzeldemirci, Nuray Ulusoy; Küçükbasmacı, Ömer (2010-01-01). "Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety". European Journal of Medicinal Chemistry (به انگلیسی). 45 (1): 63–68. doi:10.1016/j.ejmech.2009.09.024. PMID 19939519.
↑ Malik, Jitender K.; Soni, Himesh; Singhai, A.K. (2013-01-01). "Synthesis, characterization and evaluation for antifungal activity of substituted diaryl imidazo [2, 1, b]-benzothiazole". Journal of Pharmacy Research (به انگلیسی). 7 (1): 39–46. doi:10.1016/j.jopr.2013.01.002.
↑ Amarouch, Hamid; Loiseau, Philippe R; Bacha, Catarina; Caujolle, Raymond; Payard, Marc; Loiseau, Philippe M; Bories, Christian; Gayral, Philippe (1987-09-01). "Imidazo[2,1-b]thiazoles: analogues du lévamisole". European Journal of Medicinal Chemistry (به فرانسوی). 22 (5): 463–466. doi:10.1016/0223-5234(87)90037-7.

[1] Fascio, Mirta L.; Errea, María Inés; D'Accorso, Norma Beatriz (2015-01-27). "Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties". European Journal of Medicinal Chemistry (به انگلیسی). 90: 666–683. doi:10.1016/j.ejmech.2014.12.012. PMID 25499987.

[2] Gürsoy, Elif; Güzeldemirci, Nuray Ulusoy (2007-03-01). "Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives". European Journal of Medicinal Chemistry (به انگلیسی). 42 (3): 320–326. doi:10.1016/j.ejmech.2006.10.012. PMID 17145120.

[3] Andreani, Aldo; Granaiola, Massimiliano; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Varoli, Lucilla; Lannigan, Deborah; Smith, Jeff (2011-09-01). "Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors [1]". European Journal of Medicinal Chemistry (به انگلیسی). 46 (9): 4311–4323. doi:10.1016/j.ejmech.2011.07.001. PMID 21794960. {{cite journal}}: |hdl-access= requires |hdl= (help)

[4] Park, Jin-Hun; El-Gamal, Mohammed I.; Lee, Yong Sup; Oh, Chang-Hyun (2011-12-01). "New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies". European Journal of Medicinal Chemistry (به انگلیسی). 46 (12): 5769–5777. doi:10.1016/j.ejmech.2011.08.024. PMID 22033063.

[5] Cole, Derek C.; Stock, Joseph R.; Lennox, William J.; Bernotas, Ronald C.; Ellingboe, John W.; Boikess, Steve; Coupet, Joseph; Smith, Deborah L.; Leung, Louis (2007-11-01). "Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist". Journal of Medicinal Chemistry. 50 (23): 5535–5538. doi:10.1021/jm070521y. PMID 17948978.

[6] Güzeldemirci, Nuray Ulusoy; Küçükbasmacı, Ömer (2010-01-01). "Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety". European Journal of Medicinal Chemistry (به انگلیسی). 45 (1): 63–68. doi:10.1016/j.ejmech.2009.09.024. PMID 19939519.

[7] Malik, Jitender K.; Soni, Himesh; Singhai, A.K. (2013-01-01). "Synthesis, characterization and evaluation for antifungal activity of substituted diaryl imidazo [2, 1, b]-benzothiazole". Journal of Pharmacy Research (به انگلیسی). 7 (1): 39–46. doi:10.1016/j.jopr.2013.01.002.

[8] Amarouch, Hamid; Loiseau, Philippe R; Bacha, Catarina; Caujolle, Raymond; Payard, Marc; Loiseau, Philippe M; Bories, Christian; Gayral, Philippe (1987-09-01). "Imidazo[2,1-b]thiazoles: analogues du lévamisole". European Journal of Medicinal Chemistry (به فرانسوی). 22 (5): 463–466. doi:10.1016/0223-5234(87)90037-7.

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