از ویکی‌پدیا، دانشنامهٔ آزاد
گیرندهٔ چشایی نوع ۲، عضو ۱۰ (انگلیسی : Taste receptor type 2 member 10 TAS2R10 » کُدگذاری می‌شود.[۴] [۵] [۶]
این ژن و پروتئینش در حسِ چشایی در انسان و شناخت مزه تلخی نقش دارند.
این گیرندهٔ چشایی علاوه بر زبان، در ماهیچه‌های صاف مجاری تنفسی نیز بیان می‌شود و می‌تواند باعث گشادی مجاری تنفسی گردد.[۷]
↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000063478 - Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell . 100 (6): 693–702. doi :10.1016/S0092-8674(00)80705-9 . PMID 10761934 . ↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601–4. doi :10.1038/35007072 . PMID 10766242 . ↑ "Entrez Gene: TAS2R10 taste receptor, type 2, member 10" .↑ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction" . Nat. Med . 16 (11): 1299–304. doi :10.1038/nm.2237 . PMC 3066567 PMID 20972434 .
بیشتر بخوانید [ ویرایش ]
Kinnamon SC (2000). "A plethora of taste receptors". Neuron . 25 (3): 507–10. doi :10.1016/S0896-6273(00)81054-5 . PMID 10774719 . Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem . 277 (1): 1–4. doi :10.1074/jbc.R100054200 . PMID 11696554 . Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol . 12 (4): 366–71. doi :10.1016/S0959-4388(02)00345-8 . PMID 12139982 . Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell . 100 (6): 703–11. doi :10.1016/S0092-8674(00)80706-0 . PMID 10761935 . Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell . 112 (3): 293–301. doi :10.1016/S0092-8674(03)00071-0 . PMID 12581520 . Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes" . Mol. Biol. Evol . 22 (3): 432–6. doi :10.1093/molbev/msi027 . PMID 15496549 . Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates" . Genetics . 170 (1): 313–26. doi :10.1534/genetics.104.037523 . PMC 1449719 PMID 15744053 . Mueller KL, Hoon MA, Erlenbach I, Chandrashekar J, Zuker CS, Ryba NJ (2005). "The receptors and coding logic for bitter taste". Nature . 434 (7030): 225–9. doi :10.1038/nature03352 . PMID 15759003 .
