از ویکی‌پدیا، دانشنامهٔ آزاد
مزوتلین (انگلیسی : Mesothelin پروتئین است که در انسان توسط ژن «MSLN » کُدگذاری می‌شود.[۴] [۵] مزوتلیال بیان می‌شود[۶] [۷]
اهمیت بالینی [ ویرایش ] امروزه مشخص شده است که این پروتئین در چندین تومور انسانی بیش از حد ساخته می شودِ از جمله مزوتلیوما ، سرطان تخمدان ، آدنوکارسینوم لوزالمعده[۶] سرطان لوزالمعده )، آدنوکارسینوم ریه[۸] کلانژیوکارسینوما [۹] مزوتلیال پوشاننده پرده جنب ،[۱۰] صفاق و پریکارد وجود دارد.[۶] بیان می‌شود و ایمونوژنیک است، این پروتئین را می‌توان به عنوان نشانگر تومور یا به عنوان هدف آنتی‌ژنی برای واکسن‌درمانی سرطان مورد استفاده قرار داد.[۱۱] [۱۲]
↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000063011 - Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Kojima T, Oh-eda M, Hattori K, Taniguchi Y, Tamura M, Ochi N, Yamaguchi N (September 1995). "Molecular cloning and expression of megakaryocyte potentiating factor cDNA" . The Journal of Biological Chemistry . 270 (37): 21984–21990. doi :10.1074/jbc.270.37.21984 PMID 7665620 . ↑ Chang K, Pastan I (January 1996). "Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers" . Proceedings of the National Academy of Sciences of the United States of America . 93 (1): 136–140. Bibcode :1996PNAS...93..136C . doi :10.1073/pnas.93.1.136 PMC 40193 PMID 8552591 . ↑ ۶٫۰ ۶٫۱ ۶٫۲ Hassan R, Ho M (January 2008). "Mesothelin targeted cancer immunotherapy" . European Journal of Cancer . 44 (1): 46–53. doi :10.1016/j.ejca.2007.08.028 . PMC 2265108 PMID 17945478 . ↑ Chang K, Pai LH, Batra JK, Pastan I, Willingham MC (January 1992). "Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium". Cancer Research . 52 (1): 181–186. PMID 1727378 . ↑ Ho M, Bera TK, Willingham MC, Onda M, Hassan R, FitzGerald D, Pastan I (March 2007). "Mesothelin expression in human lung cancer" . Clinical Cancer Research . 13 (5): 1571–1575. doi :10.1158/1078-0432.CCR-06-2161 PMID 17332303 . ↑ Yu L, Feng M, Kim H, Phung Y, Kleiner DE, Gores GJ, et al. (October 2010). "Mesothelin as a potential therapeutic target in human cholangiocarcinoma" . Journal of Cancer . 1 : 141–149. doi :10.7150/jca.1.141 . PMC 2948219 PMID 20922056 . ↑ Grosso F, Mannucci M, Ugo F, Ferro P, Cassinari M, Vigani A, et al. (October 2021). "Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score" . Diagnostics . 11 (11): 2015. doi :10.3390/diagnostics11112015 PMC 8623660 PMID 34829362 . ↑ Hassan R, Bera T, Pastan I (June 2004). "Mesothelin: a new target for immunotherapy" . Clinical Cancer Research . 10 (12 Pt 1): 3937–3942. doi :10.1158/1078-0432.CCR-03-0801 PMID 15217923 . ↑ Hassan R, Ho M (January 2008). "Mesothelin targeted cancer immunotherapy" . European Journal of Cancer . 44 (1): 46–53. doi :10.1016/j.ejca.2007.08.028 . PMC 2265108 PMID 17945478 .
برای مطالعهٔ بیشتر [ ویرایش ]
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