درج‌حذف

درج‌حرف یا ایندل (به انگلیسی: Indel) (کوتاه‌شدهٔ insertion-deletion) یک اصطلاح زیست‌شناسی مولکولی برای درج یا حذف بازها در ژنوم یک جاندار زنده است. درج‌حذف‌های ≥ ۵۰ پایه در طول به عنوان گوناگونی ساختاری طبقه‌بندی می‌شوند.^[۱]^[۲]

درج‌حذف‌ها، به عنوان درج یا حذف، می‌تواند به عنوان نشانگر ژنتیکی در جمعیت‌های طبیعی، به‌ویژه در مطالعات تبارزایی استفاده شوند.^[۳]^[۴] نشان داده شده‌است که نواحی ژنومی با درج‌حذف‌های متعدد نیز می‌توانند برای روش‌های شناسایی گونه به کار روند.^[۵]^[۶]^[۷]

منابع[ویرایش]

↑ Mahmoud, Medhat; Gobet, Nastassia; Cruz-Dávalos, Diana Ivette; Mounier, Ninon; Dessimoz, Christophe; Sedlazeck, Fritz J. (2019). "Structural variant calling: the long and the short of it". Genome Biology. 20. doi:10.1186/s13059-019-1828-7. PMC 6868818.
↑ Ebert, Peter; Audano, Peter A.; Zhu, Qihui; Rodriguez-Martin, Bernardo; Porubsky, David; Bonder, Marc Jan; Sulovari, Arvis; Ebler, Jana; Zhou, Weichen (2021). "Haplotype-resolved diverse human genomes and integrated analysis of structural variation". Science. 372 (6537). doi:10.1126/science.abf7117. PMC 8026704. {{cite journal}}: Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)
↑ Väli U, Brandström M, Johansson M, Ellegren H (January 2008). "Insertion-deletion polymorphisms (indels) as genetic markers in natural populations". BMC Genetics. 9: 8. doi:10.1186/1471-2156-9-8. PMC 2266919. PMID 18211670.
↑ Erixon P, Oxelman B (January 2008). "Whole-gene positive selection, elevated synonymous substitution rates, duplication, and indel evolution of the chloroplast clpP1 gene". PLOS ONE. 3 (1): e1386. Bibcode:2008PLoSO...3.1386E. doi:10.1371/journal.pone.0001386. PMC 2148103. PMID 18167545.
↑ Pereira F, Carneiro J, Matthiesen R, van Asch B, Pinto N, Gusmão L, Amorim A (December 2010). "Identification of species by multiplex analysis of variable-length sequences". Nucleic Acids Research. 38 (22): e203. doi:10.1093/nar/gkq865. PMC 3001097. PMID 20923781.
↑ Nakamura H, Muro T, Imamura S, Yuasa I (March 2009). "Forensic species identification based on size variation of mitochondrial DNA hypervariable regions". International Journal of Legal Medicine. 123 (2): 177–184. doi:10.1007/s00414-008-0306-7. PMID 19052767.
↑ Taberlet P, Coissac E, Pompanon F, Gielly L, Miquel C, Valentini A, Vermat T, Corthier G, Brochmann C, Willerslev E (26 January 2007). "Power and limitations of the chloroplast trnL (UAA) intron for plant DNA barcoding". Nucleic Acids Research. 35 (3): e14. doi:10.1093/nar/gkl938. PMC 1807943. PMID 17169982. {{cite journal}}: Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)

[1] Mahmoud, Medhat; Gobet, Nastassia; Cruz-Dávalos, Diana Ivette; Mounier, Ninon; Dessimoz, Christophe; Sedlazeck, Fritz J. (2019). "Structural variant calling: the long and the short of it". Genome Biology. 20. doi:10.1186/s13059-019-1828-7. PMC 6868818.

[2] Ebert, Peter; Audano, Peter A.; Zhu, Qihui; Rodriguez-Martin, Bernardo; Porubsky, David; Bonder, Marc Jan; Sulovari, Arvis; Ebler, Jana; Zhou, Weichen (2021). "Haplotype-resolved diverse human genomes and integrated analysis of structural variation". Science. 372 (6537). doi:10.1126/science.abf7117. PMC 8026704. {{cite journal}}: Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)

[Vali2008-3] Väli U, Brandström M, Johansson M, Ellegren H (January 2008). "Insertion-deletion polymorphisms (indels) as genetic markers in natural populations". BMC Genetics. 9: 8. doi:10.1186/1471-2156-9-8. PMC 2266919. PMID 18211670.

[Erixon2008-4] Erixon P, Oxelman B (January 2008). "Whole-gene positive selection, elevated synonymous substitution rates, duplication, and indel evolution of the chloroplast clpP1 gene". PLOS ONE. 3 (1): e1386. Bibcode:2008PLoSO...3.1386E. doi:10.1371/journal.pone.0001386. PMC 2148103. PMID 18167545.

[5] Pereira F, Carneiro J, Matthiesen R, van Asch B, Pinto N, Gusmão L, Amorim A (December 2010). "Identification of species by multiplex analysis of variable-length sequences". Nucleic Acids Research. 38 (22): e203. doi:10.1093/nar/gkq865. PMC 3001097. PMID 20923781.

[6] Nakamura H, Muro T, Imamura S, Yuasa I (March 2009). "Forensic species identification based on size variation of mitochondrial DNA hypervariable regions". International Journal of Legal Medicine. 123 (2): 177–184. doi:10.1007/s00414-008-0306-7. PMID 19052767.

[7] Taberlet P, Coissac E, Pompanon F, Gielly L, Miquel C, Valentini A, Vermat T, Corthier G, Brochmann C, Willerslev E (26 January 2007). "Power and limitations of the chloroplast trnL (UAA) intron for plant DNA barcoding". Nucleic Acids Research. 35 (3): e14. doi:10.1093/nar/gkl938. PMC 1807943. PMID 17169982. {{cite journal}}: Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)

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