SETD2

SETD2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2A7O, 2MDC, 2MDI, 2MDJ, 4FMU, 4H12
معین‌کننده‌ها
نام‌های دیگر	SETD2, HBP231, HIF-1, HIP-1, HYPB, KMT3A, SET2, p231HBP, HSPC069, LLS, SET domain containing 2
شناسه‌های بیرونی	OMIM: 612778 MGI: 1918177 HomoloGene: 56493 GeneCards: SETD2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	110,618,633 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0102674، GO:0102675 methyltransferase activity; • transferase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • histone-lysine N-methyltransferase activity; • protein-lysine N-methyltransferase activity; • alpha-tubulin binding; • histone methyltransferase activity (H3-K36 specific); • metal ion binding;
ترکیبات سلولی	• نوکلئوپلاسم; • هسته یاخته; • کروموزوم;
فرایند زیستی	• GO:0009373 regulation of transcription, DNA-templated; • histone H3-K36 dimethylation; • regulation of mRNA export from nucleus; • embryonic organ development; • stem cell development; • embryonic placenta morphogenesis; • transcription elongation from RNA polymerase II promoter; • coronary vasculature morphogenesis; • cell migration involved in vasculogenesis; • morphogenesis of a branching structure; • transcription, DNA-templated; • mesoderm morphogenesis; • vasculogenesis; • histone H3-K36 methylation; • متیل‌دار کردن; • neural tube closure; • GO:0016584، GO:0001207، GO:0042766، GO:0001208، GO:0060303 nucleosome organization; • رگ‌زایی; • pericardium development; • ساماندهی بیان ژن; • histone H3-K36 trimethylation; • embryonic cranial skeleton morphogenesis; • بازسازی نابرابر دی‌ان‌ای; • histone lysine methylation; • forebrain development; • regulation of double-strand break repair via homologous recombination; • peptidyl-lysine trimethylation; • peptidyl-lysine monomethylation; • regulation of cytokinesis; • positive regulation of interferon-alpha production; • response to type I interferon; • endodermal cell differentiation; • stem cell differentiation; • microtubule cytoskeleton organization involved in mitosis; • regulation of protein localization to chromatin; • immune system process; • GO:0100026 بازسازی دی‌ان‌ای; • cellular response to DNA damage stimulus; • multicellular organism development; • دگرگونی یاخته‌; • دستگاه ایمنی ذاتی; • defense response to virus; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	29072
	235626
	ENSG00000181555
	ENSMUSG00000044791
	Q9BYW2
	E9Q5F9
	NM_014159، XM_011533631، XM_011533632، XM_011533633، XM_011533634، XR_940418، XM_017006270، XR_001740125، XR_001740126، XR_001740127، XR_001740128، XR_001740129، XR_001740130، XR_001740131، XR_001740132، XR_001740133، NM_001349370، NR_146158 NM_012271، NM_014159، XM_011533631، XM_011533632، XM_011533633، XM_011533634، XR_940418، XM_017006270، XR_001740125، XR_001740126، XR_001740127، XR_001740128، XR_001740129، XR_001740130، XR_001740131، XR_001740132، XR_001740133، NM_001349370، NR_146158
	XM_006512088، XM_006512091، XM_006512092، XM_017313351، XR_001778892، XR_001778893 NM_001081340، XM_006512088، XM_006512091، XM_006512092، XM_017313351، XR_001778892، XR_001778893
	XP_011531934، XP_011531936، NP_001336299، XP_024309255، XP_024309256، XP_024309257 NP_054878، XP_011531934، XP_011531936، NP_001336299، XP_024309255، XP_024309256، XP_024309257
	XP_006512151، XP_006512154، XP_006512155، XP_036010808، XP_036010809، XP_036010810، XP_036010811 NP_001074809، XP_006512151، XP_006512154، XP_006512155، XP_036010808، XP_036010809، XP_036010810، XP_036010811
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

دومین شمارهٔ ۲ حاوی SET (انگلیسی: SET domain containing 2) یک آنزیم است که در انسان توسط ژن «SETD2» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

اهمیت بالینی[ویرایش]

این آنزیم با هانتینگتین، تعامل پروتئین-پروتئین دارد^[۷] و در سرطان‌های انسان، سرکوب‌کنندهٔ تومور است.^[۸]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000044791 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z (Oct 2005). "Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase". J Biol Chem. 280 (42): 35261–71. doi:10.1074/jbc.M504012200. PMID 16118227.
↑ Rega S, Stiewe T, Chang DI, Pollmeier B, Esche H, Bardenheuer W, Marquitan G, Putzer BM (Jul 2001). "Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor". Mol Cell Neurosci. 18 (1): 68–79. doi:10.1006/mcne.2001.1004. PMID 11461154.
↑ "Entrez Gene: SETD2 SET domain containing 2".
↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (September 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
↑ Al Sarakbi W, Sasi W, Jiang WG, Roberts T, Newbold RF, Mokbel K (2009). "The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters". BMC Cancer. 9: 290. doi:10.1186/1471-2407-9-290. PMC 3087337. PMID 19698110.

مشارکت‌کنندگان ویکی‌پدیا. «SETD2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۶ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

Faber PW, Barnes GT, Srinidhi J, et al. (1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
Passani LA, Bedford MT, Faber PW, et al. (2000). "Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis". Hum. Mol. Genet. 9 (14): 2175–82. doi:10.1093/hmg/9.14.2175. PMID 10958656.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li M, Phatnani HP, Guan Z, et al. (2006). "Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1". Proc. Natl. Acad. Sci. U.S.A. 102 (49): 17636–41. doi:10.1073/pnas.0506350102. PMC 1308900. PMID 16314571.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000044791 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_16118227-4] Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z (Oct 2005). "Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase". J Biol Chem. 280 (42): 35261–71. doi:10.1074/jbc.M504012200. PMID 16118227.

[pmid_11461154-5] Rega S, Stiewe T, Chang DI, Pollmeier B, Esche H, Bardenheuer W, Marquitan G, Putzer BM (Jul 2001). "Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor". Mol Cell Neurosci. 18 (1): 68–79. doi:10.1006/mcne.2001.1004. PMID 11461154.

[entrez-6] "Entrez Gene: SETD2 SET domain containing 2".

[pmid_9700202-7] Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (September 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.

[pmid_19698110-8] Al Sarakbi W, Sasi W, Jiang WG, Roberts T, Newbold RF, Mokbel K (2009). "The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters". BMC Cancer. 9: 290. doi:10.1186/1471-2407-9-290. PMC 3087337. PMID 19698110.

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