PGK1

PGK1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2WZB, 2WZC, 2WZD, 2X13, 2X14, 2X15, 2XE6, 2XE7, 2XE8, 2Y3I, 2YBE, 2ZGV, 3C39, 3C3A, 3C3B, 3C3C, 3ZOZ, 4AXX, 4O33
معین‌کننده‌ها
نام‌های دیگر	PGK1, HEL-S-68p, MIG10, PGKA, phosphoglycerate kinase 1
شناسه‌های بیرونی	OMIM: 311800 MGI: 97555 HomoloGene: 21542 GeneCards: PGK1
موقعیت ژن (انسان)
کروموزوم	کروموزوم X (انسان)
پایان	78,129,295 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم X (موش)
پایان	105,247,305 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • ATP binding; • kinase activity; • phosphoglycerate kinase activity; • protein-disulfide reductase (NAD(P)) activity; • ADP binding;
ترکیبات سلولی	• سیتوپلاسم; • لیپید رفت; • سیتوزول; • extracellular exosome; • membrane; • extracellular space;
فرایند زیستی	• نوگلوکززایی; • epithelial cell differentiation; • فسفرگیری; • canonical glycolysis; • قندکافت; • negative regulation of angiogenesis; • plasminogen activation; • cellular response to hypoxia; • response to hypoxia; • chemical synaptic transmission; • myoblast fusion; • somatic muscle development; • muscle cell cellular homeostasis; • positive regulation of oxidative phosphorylation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5230
	18655
	ENSG00000102144
	ENSMUSG00000062070
	P00558
	P09411
	NM_000291
	NM_008828
	NP_000282
	NP_032854
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فسفوگلیسرات کیناز ۱ (انگلیسی: Phosphoglycerate kinase 1) یک آنزیم است که در انسان توسط ژن «PGK1» کُدگذاری می‌شود.^[۵]^[۶]^[۷] PGK1 در تمامی سلول‌های بدن یافت می‌شود.^[۸]

اهمیت بالینی[ویرایش]

افزایش بیان PGK1 در سرطان معده یافت شده‌است و در مطالعات آزمایشگاهی مشاهده گردیده که حالت تهاجمی آنرا تشدید می‌کند.^[۹]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000102144 - Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000062070 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Michelson AM, Markham AF, Orkin SH (May 1983). "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase". Proc Natl Acad Sci U S A. 80 (2): 472–6. doi:10.1073/pnas.80.2.472. PMC 393400. PMID 6188151.
↑ Singer-Sam J, Keith DH, Tani K, Simmer RL, Shively L, Lindsay S, Yoshida A, Riggs AD (May 1985). "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]". Gene. 32 (3): 409–17. doi:10.1016/0378-1119(84)90016-7. PMID 6099325.
↑ "Entrez Gene: PGK1 phosphoglycerate kinase 1".
↑ Chiarelli LR, Morera SM, Bianchi P, Fermo E, Zanella A, Galizzi A, Valentini G (2012). "Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency". PLOS ONE. 7 (2): e32065. doi:10.1371/journal.pone.0032065. PMC 3279470. PMID 22348148.
↑ Zieker D, Königsrainer I, Tritschler I, Löffler M, Beckert S, Traub F, Nieselt K, Bühler S, Weller M, Gaedcke J, Taichman RS, Northoff H, Brücher BL, Königsrainer A (March 2010). "Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer". International Journal of Cancer. 126 (6): 1513–20. doi:10.1002/ijc.24835. PMC 2811232. PMID 19688824.

مشارکت‌کنندگان ویکی‌پدیا. «PGK1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۱ اکتبر ۲۰۱۸.

بیشتر بخوانید[ویرایش]

Vishwanatha JK, Jindal HK, Davis RG (1992). "The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells". J. Cell Sci. 101. ( Pt 1): 25–34. PMID 1533225.
Fujii H, Kanno H, Hirono A, et al. (1992). "A single amino acid substitution (157 Gly----Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria". Blood. 79 (6): 1582–5. PMID 1547346.
Maeda M, Bawle EV, Kulkarni R, et al. (1992). "Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation". Blood. 79 (10): 2759–62. PMID 1586722.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Kumble KD, Vishwanatha JK (1992). "Immunoelectron microscopic analysis of the intracellular distribution of primer recognition proteins, annexin 2 and phosphoglycerate kinase, in normal and transformed cells". J. Cell Sci. 99. ( Pt 4): 751–8. PMID 1837552.
Maeda M, Yoshida A (1991). "Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3". Blood. 77 (6): 1348–52. PMID 2001457.
Jindal HK, Vishwanatha JK (1990). "Functional identity of a primer recognition protein as phosphoglycerate kinase". J. Biol. Chem. 265 (12): 6540–3. PMID 2324090.
Johnson P, Friedmann T (1990). "Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK". Gene. 88 (2): 207–13. doi:10.1016/0378-1119(90)90033-N. PMID 2347494.
Pfeifer GP, Steigerwald SD, Mueller PR, et al. (1989). "Genomic sequencing and methylation analysis by ligation mediated PCR". Science. 246 (4931): 810–3. doi:10.1126/science.2814502. PMID 2814502.
Michelson AM, Blake CC, Evans ST, Orkin SH (1985). "Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain". Proc. Natl. Acad. Sci. U.S.A. 82 (20): 6965–9. doi:10.1073/pnas.82.20.6965. PMC 391290. PMID 2995995.
McCarrey JR, Thomas K (1987). "Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene". Nature. 326 (6112): 501–5. doi:10.1038/326501a0. PMID 3453121.
Fujii H, Yoshida A (1981). "Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia". Proc. Natl. Acad. Sci. U.S.A. 77 (9): 5461–5. doi:10.1073/pnas.77.9.5461. PMC 350080. PMID 6933565.
Fujii H, Chen SH, Akatsuka J, et al. (1981). "Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia". Proc. Natl. Acad. Sci. U.S.A. 78 (4): 2587–90. doi:10.1073/pnas.78.4.2587. PMC 319394. PMID 6941312.
Huang IY, Welch CD, Yoshida A (1980). "Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence". J. Biol. Chem. 255 (13): 6412–20. PMID 7391027.
Fujii H, Krietsch WK, Yoshida A (1980). "A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency". J. Biol. Chem. 255 (13): 6421–3. PMID 7391028.
Huang IY, Fujii H, Yoshida A (1981). "Structure and function of normal and variant human phosphoglycerate kinase". Hemoglobin. 4 (5–6): 601–9. doi:10.3109/03630268008997730. PMID 7440217.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Hershkovitz M, Riggs AD (1995). "Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2379–83. doi:10.1073/pnas.92.6.2379. PMC 42487. PMID 7892275.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000102144 - Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000062070 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6188151-5] Michelson AM, Markham AF, Orkin SH (May 1983). "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase". Proc Natl Acad Sci U S A. 80 (2): 472–6. doi:10.1073/pnas.80.2.472. PMC 393400. PMID 6188151.

[pmid6099325-6] Singer-Sam J, Keith DH, Tani K, Simmer RL, Shively L, Lindsay S, Yoshida A, Riggs AD (May 1985). "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]". Gene. 32 (3): 409–17. doi:10.1016/0378-1119(84)90016-7. PMID 6099325.

[7] "Entrez Gene: PGK1 phosphoglycerate kinase 1".

[Chiarelli2012-8] Chiarelli LR, Morera SM, Bianchi P, Fermo E, Zanella A, Galizzi A, Valentini G (2012). "Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency". PLOS ONE. 7 (2): e32065. doi:10.1371/journal.pone.0032065. PMC 3279470. PMID 22348148.

[9] Zieker D, Königsrainer I, Tritschler I, Löffler M, Beckert S, Traub F, Nieselt K, Bühler S, Weller M, Gaedcke J, Taichman RS, Northoff H, Brücher BL, Königsrainer A (March 2010). "Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer". International Journal of Cancer. 126 (6): 1513–20. doi:10.1002/ijc.24835. PMC 2811232. PMID 19688824.

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