گیرنده ۱ هورمون پاراتیروئید

PTH1R
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1BL1, 3C4M, 3H3G, 3L2J, 4Z8J
معین‌کننده‌ها
نام‌های دیگر	PTH1R, PFE, PTHR, PTHR1, Parathyroid hormone 1 receptor, EKNS
شناسه‌های بیرونی	OMIM: 168468 MGI: 97801 HomoloGene: 267 GeneCards: PTH1R
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	110,747,145 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• G protein-coupled receptor activity; • parathyroid hormone receptor activity; • signal transducer activity; • protein self-association; • peptide hormone binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • transmembrane signaling receptor activity; • protein homodimerization activity; • G protein-coupled peptide receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • membrane; • receptor complex; • پوسته یاخته; • intracellular anatomical structure; • brush border membrane; • basolateral plasma membrane; • apical plasma membrane; • هسته یاخته; • integral component of plasma membrane;
فرایند زیستی	• skeletal system development; • G protein-coupled receptor signaling pathway; • bone mineralization; • chondrocyte differentiation; • استخوان‌سازی; • positive regulation of inositol phosphate biosynthetic process; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • GO:0010260 پیرش; • cellular calcium ion homeostasis; • cell maturation; • bone resorption; • phospholipase C-activating G protein-coupled receptor signaling pathway; • cell surface receptor signaling pathway; • positive regulation of cell population proliferation; • osteoblast development; • GO:0072468 ورارسانی پیام; • negative regulation of cell population proliferation; • adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5745
	19228
	ENSG00000160801
	ENSMUSG00000032492
	Q03431
	P41593
	NM_000316، NM_001184744، XM_011533967، XM_017006932، XM_017006934، XM_047448632، XM_047448633 XM_011533968، NM_000316، NM_001184744، XM_011533967، XM_017006932، XM_017006934، XM_047448632، XM_047448633
	NM_001083936، NM_011199، XM_006511985، XM_006511987، XM_006511988، XM_011242942، XM_017313214، XM_017313215 NM_001083935، NM_001083936، NM_011199، XM_006511985، XM_006511987، XM_006511988، XM_011242942، XM_017313214، XM_017313215
	NP_001171673، XP_005265401، XP_011532269، XP_011532270، XP_016862421، XP_016862422، XP_016862423 NP_000307، NP_001171673، XP_005265401، XP_011532269، XP_011532270، XP_016862421، XP_016862422، XP_016862423
	NP_001077405، NP_035329، XP_006512048، XP_006512051، XP_036010598، XP_036010599، XP_036010600، XP_036010601، XP_036010602، XP_036010603، XP_036010604، XP_036010605، XP_036010606 NP_001077404، NP_001077405، NP_035329، XP_006512048، XP_006512051، XP_036010598، XP_036010599، XP_036010600، XP_036010601، XP_036010602، XP_036010603، XP_036010604، XP_036010605، XP_036010606
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده ۱ هورمون پاراتیروئید (انگلیسی: Parathyroid hormone 1 receptor) یک پروتئین است که در انسان توسط ژن «PTH1R» کدگذاری می‌شود.

این مولکول پروتئینی گیرندهٔ هورمون پاراتیروئید و پروتئین شبه هورمون پاراتیروئید (PTHrP) است و در تنظیم هم‌ایستایی یون کلسیم از طریق فعال‌سازی آدنیلات سیکلاز و فسفولیپاز سی نقش دارد.^[۴]^[۵]

اهمیت بالینی[ویرایش]

نقص در این گیرنده موجب بروز «کندرودیسپلازی متافیزی یانسن» (JMC)، «کندرودیسپلازی بلومستراند» (BOCD) و «اِنکندروماتوز»^[۶] و «اختلال اولیه رشد دندان» می گردد.^[۷]

جستارهای وابسته[ویرایش]

گیرنده هورمون پاراتیروئید

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032492 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mannstadt M, Jüppner H, Gardella TJ (Nov 1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". The American Journal of Physiology. 277 (5 Pt 2): F665-75. PMID 10564229. Archived from the original on 13 February 2009. Retrieved 25 December 2018.
↑ Offermanns S, Iida-Klein A, Segre GV, Simon MI (May 1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Molecular Endocrinology. 10 (5): 566–74. doi:10.1210/me.10.5.566. PMID 8732687.
↑ "Entrez Gene: PTH1R parathyroid hormone 1 receptor".
↑ Yamaguchi T, Hosomichi K, Narita A, Shirota T, Tomoyasu Y, Maki K, Inoue I (Jul 2011). "Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese". Journal of Bone and Mineral Research. 26 (7): 1655–61. doi:10.1002/jbmr.385. PMID 21404329.

مشارکت‌کنندگان ویکی‌پدیا. «Parathyroid hormone 1 receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر[ویرایش]

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Schipani E, Weinstein LS, Bergwitz C, Iida-Klein A, Kong XF, Stuhrmann M, Kruse K, Whyte MP, Murray T, Schmidtke J (May 1995). "Pseudohypoparathyroidism type Ib is not caused by mutations in the coding exons of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene". The Journal of Clinical Endocrinology and Metabolism. 80 (5): 1611–21. doi:10.1210/jc.80.5.1611. PMID 7745008.
Pausova Z, Bourdon J, Clayton D, Mattei MG, Seldin MF, Janicic N, Rivière M, Szpirer J, Levan G, Szpirer C (Mar 1994). "Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes". Genomics. 20 (1): 20–6. doi:10.1006/geno.1994.1122. PMID 8020952.
McCuaig KA, Clarke JC, White JH (May 1994). "Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor". Proceedings of the National Academy of Sciences of the United States of America. 91 (11): 5051–5. doi:10.1073/pnas.91.11.5051. PMC 43929. PMID 8197183.
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Jobert AS, Zhang P, Couvineau A, Bonaventure J, Roume J, Le Merrer M, Silve C (Jul 1998). "Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia". The Journal of Clinical Investigation. 102 (1): 34–40. doi:10.1172/JCI2918. PMC 509062. PMID 9649554.
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پیوند به بیرون[ویرایش]

Receptor, Parathyroid Hormone, Type 1 در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032492 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10564229-4] Mannstadt M, Jüppner H, Gardella TJ (Nov 1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". The American Journal of Physiology. 277 (5 Pt 2): F665-75. PMID 10564229. Archived from the original on 13 February 2009. Retrieved 25 December 2018.

[pmid8732687-5] Offermanns S, Iida-Klein A, Segre GV, Simon MI (May 1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Molecular Endocrinology. 10 (5): 566–74. doi:10.1210/me.10.5.566. PMID 8732687.

[entrez-6] "Entrez Gene: PTH1R parathyroid hormone 1 receptor".

[pmid21404329-7] Yamaguchi T, Hosomichi K, Narita A, Shirota T, Tomoyasu Y, Maki K, Inoue I (Jul 2011). "Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese". Journal of Bone and Mineral Research. 26 (7): 1655–61. doi:10.1002/jbmr.385. PMID 21404329.

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