اینترلوکین ۱ بتا

IL1B
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP
معین‌کننده‌ها
نام‌های دیگر	IL1B, IL-1, IL1-BETA, IL1F2, interleukin 1 beta, IL1beta
شناسه‌های بیرونی	OMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	129,213,059 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein domain specific binding; • interleukin-1 receptor binding; • cytokine activity; • integrin binding; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • extracellular region; • کافنده‌تن; • extracellular exosome; • secretory granule; • ریزکیسه; • extracellular space;
فرایند زیستی	• positive regulation of protein phosphorylation; • smooth muscle adaptation; • positive regulation of calcidiol 1-monooxygenase activity; • GO:1903105 negative regulation of insulin receptor signaling pathway; • cellular response to mechanical stimulus; • positive regulation of interleukin-8 production; • positive regulation of mitotic nuclear division; • response to carbohydrate; • embryo implantation; • regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of cell population proliferation; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • cellular response to organic substance; • positive regulation of phagocytosis; • regulation of insulin secretion; • neutrophil chemotaxis; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of protein export from nucleus; • positive regulation of prostaglandin secretion; • positive regulation of myosin light chain kinase activity; • مپ کیناز; • positive regulation of T cell proliferation; • positive regulation of interleukin-6 production; • inflammatory response; • negative regulation of lipid metabolic process; • sequestering of triglyceride; • hyaluronan biosynthetic process; • positive regulation of heterotypic cell-cell adhesion; • positive regulation of lipid catabolic process; • GO:1904579 cellular response to organic cyclic compound; • positive regulation of fever generation; • positive regulation of DNA-binding transcription factor activity; • positive regulation of angiogenesis; • response to lipopolysaccharide; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of granulocyte macrophage colony-stimulating factor production; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • ectopic germ cell programmed cell death; • leukocyte migration; • lipopolysaccharide-mediated signaling pathway; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of cell adhesion molecule production; • response to ATP; • monocyte aggregation; • protein kinase B signaling; • positive regulation of nitric oxide biosynthetic process; • cell-cell signaling; • positive regulation of monocyte chemotactic protein-1 production; • regulation of nitric-oxide synthase activity; • positive regulation of membrane protein ectodomain proteolysis; • positive regulation of interferon-gamma production; • MAPK cascade; • positive regulation of histone acetylation; • GO:1901313 positive regulation of gene expression; • negative regulation of glucose transmembrane transport; • interleukin-1 beta production; • positive regulation of T cell mediated immunity; • extrinsic apoptotic signaling pathway in absence of ligand; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of vascular endothelial growth factor production; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • negative regulation of lipid catabolic process; • negative regulation of adiponectin secretion; • regulation of establishment of endothelial barrier; • positive regulation of cell division; • GO:0072468 ورارسانی پیام; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • cytokine-mediated signaling pathway; • regulation of defense response to virus by host; • fever generation; • positive regulation of JNK cascade; • positive regulation of cell population proliferation; • regulation of signaling receptor activity; • positive regulation of epithelial to mesenchymal transition; • positive regulation of cell migration; • interleukin-6 production; • astrocyte activation; • regulation of neurogenesis; • negative regulation of neurogenesis; • negative regulation of synaptic transmission; • positive regulation of glial cell proliferation; • regulation of ERK1 and ERK2 cascade; • interleukin-1-mediated signaling pathway; • cellular response to lipopolysaccharide; • positive regulation of neuroinflammatory response; • positive regulation of p38MAPK cascade; • positive regulation of NIK/NF-kappaB signaling; • positive regulation of T-helper 1 cell cytokine production; • positive regulation of prostaglandin biosynthetic process; • positive regulation of complement activation; • positive regulation of inflammatory response; • response to interleukin-1; • positive regulation of RNA biosynthetic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3553
	16176
	ENSG00000125538
	ENSMUSG00000027398
	P01584
	P10749
	XM_047444175 NM_000576، XM_047444175
	XM_006498795 NM_008361، XM_006498795
	XP_016859477 NP_000567، XP_016859477
	XP_006498858 NP_032387، XP_006498858
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اینترلوکین ۱ بتا (انگلیسی: Interleukin 1 beta) یک سیتوکین پروتئینی است که در انسان توسط ژن «IL1B» کد می‌شود.^[۴]^[۵]^[۶]^[۷]

پیش‌سازهای اولیه این آنزیم توسط کاسپاز شکسته شده و اینترلوکین ۱ بتای بالغ ایجاد می‌شود.

این آنزیم که از خانواده اینترلوکین ۱ است، در ایجاد برخی بیماری‌هایِ خودایمنی تب‌دار موسوم به سندرم‌های دوره‌ای وابسته به کرایوپایرین نقش مهمی دارد.

جستارهای وابسته[ویرایش]

خانواده اینترلوکین ۱

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027398 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA (1984). "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA". Proc. Natl. Acad. Sci. U.S.A. 81 (24): 7907–11. doi:10.1073/pnas.81.24.7907. PMC 392262. PMID 6083565.
↑ "Catabolin" is the name given by Jeremy Saklatvala for IL-1 alpha. March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K (1985). "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs". Nature. 315 (6021): 641–7. doi:10.1038/315641a0. PMID 2989698.
↑ Clark BD, Collins KL, Gandy MS, Webb AC, Auron PE (1986). "Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene". Nucleic Acids Res. 14 (20): 7897–7914. doi:10.1093/nar/14.20.7897. PMC 311823. PMID 3490654.
↑ Bensi G, Raugei G, Palla E, Carinci V, Tornese Buonamassa D, Melli M (1987). "Human interleukin-1 beta gene". Gene. 52 (1): 95–101. doi:10.1016/0378-1119(87)90398-2. PMID 2954882.

مشارکت‌کنندگان ویکی‌پدیا. «Interleukin 1 beta». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۵ اکتبر ۲۰۱۷.

پیوند به بیرون[ویرایش]

IL1B protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027398 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_6083565-4] Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA (1984). "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA". Proc. Natl. Acad. Sci. U.S.A. 81 (24): 7907–11. doi:10.1073/pnas.81.24.7907. PMC 392262. PMID 6083565.

[pmid_2989698-5] "Catabolin" is the name given by Jeremy Saklatvala for IL-1 alpha. March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K (1985). "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs". Nature. 315 (6021): 641–7. doi:10.1038/315641a0. PMID 2989698.

[pmid_3490654-6] Clark BD, Collins KL, Gandy MS, Webb AC, Auron PE (1986). "Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene". Nucleic Acids Res. 14 (20): 7897–7914. doi:10.1093/nar/14.20.7897. PMC 311823. PMID 3490654.

[pmid_2954882-7] Bensi G, Raugei G, Palla E, Carinci V, Tornese Buonamassa D, Melli M (1987). "Human interleukin-1 beta gene". Gene. 52 (1): 95–101. doi:10.1016/0378-1119(87)90398-2. PMID 2954882.

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