نیلوتامید: تفاوت میان نسخه‌ها

محتوای حذف‌شده محتوای افزوده‌شده

درخط

نسخهٔ ‏۶ مارس ۲۰۲۲، ساعت ۱۴:۳۰

نیلوتامید که با نام های تجاری Nilandron و Anandron فروخته می شود، یک آنتی آندروژن غیر استروئیدی (NSAA) است که در درمان سرطان پروستات استفاده می شود.^[۱]^[۲]^[۳]^[۴]^[۵]^[۶]همچنین به عنوان بخشی از هورمون درمانی زنانه برای زنان تراجنسیتی و برای درمان آکنه و سبوره در زنان مورد مطالعه قرار گرفته است.^[۷]^[۸]^[۹]^[۱۰] شکل تجویز آن به صورت خوراکی است.

عوارض جانبی در مردان شامل حساس شدن و بزرگ شدن سینه‌ها، زنانه شدن، اختلال در عملکرد جنسی و گرگرفتگی است.^[۱۱]^[۱۲]^[۱۳]^[۱۴] تهوع، استفراغ، اختلالات بینایی، عدم تحمل الکل، افزایش آنزیم های کبدی و بیماری ریوی می تواند در هر دو جنس رخ دهد.^[۱۵]^[۱۶]^[۱۷]^[۱۸]^[۱۹]^[۲۰] به ندرت، نیلوتامید می تواند باعث نارسایی تنفسی و آسیب کبدی شود.^[۲۱]^[۲۲] این عوارض جانبی نامطلوب، همراه با تعدادی از موارد مرتبط با مرگ، استفاده از نیلوتامید را محدود کرده است.^[۲۳]^[۲۴]^[۲۵]

نیلوتامید به عنوان یک آنتاگونیست انتخابی گیرنده آندروژن (AR) عمل می کند و از اثرات آندروژن‌هایی مانند تستوسترون و دی‌هیدروتستوسترون (DHT) در بدن جلوگیری می کند.^[۲۶]^[۲۷] از آنجایی که بیشتر سلول‌های سرطانی پروستات برای رشد و بقا به این هورمون‌ها متکی هستند، نیلوتامید می تواند پیشرفت سرطان پروستات را کند کرده و عمر مردان مبتلا به این بیماری را افزایش دهد.^[۲۸]

نیلوتامید در سال 1977 کشف شد و برای اولین بار در سال 1987 برای استفاده پزشکی معرفی گردید.^[۲۹]^[۳۰]^[۳۱] در سال 1996 در ایالات متحده در دسترس قرار گرفت.^[۳۲]^[۳۳]^[۳۴] این دارو به دلیل اثربخشی، تحمل و ایمنی بهتر، تا حد زیادی با NSAAهای جدیدتر و بهبود یافته، یعنی بیکالوتامید و انزالوتامید جایگزین شده است و اکنون به ندرت استفاده می شود.^[۳۵]

نیلوتامید در فهرست داروهای ضروری سازمان جهانی بهداشت قرار دارد.^[۳۶]

منابع

↑ https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020169s008lbl.pdf
↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 873–. ISBN 978-1-4757-2085-3.
↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 737–. ISBN 978-3-88763-075-1.
↑ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 199–. ISBN 978-94-011-4439-1.
↑ "Nilutamide".
↑ Louis J Denis; Keith Griffiths; Amir V Kaisary; Gerald P Murphy (1 March 1999). Textbook of Prostate Cancer: Pathology, Diagnosis and Treatment: Pathology, Diagnosis and Treatment. CRC Press. pp. 280–. ISBN 978-1-85317-422-3.
↑ Louis Denis (6 December 2012). Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment. Springer Science & Business Media. pp. 194–210. ISBN 978-3-642-45745-6.
↑ Baudewijntje P.C. Kreukels; Thomas D. Steensma; Annelou L.C. de Vries (1 July 2013). Gender Dysphoria and Disorders of Sex Development: Progress in Care and Knowledge. Springer Science & Business Media. pp. 280–. ISBN 978-1-4614-7441-8.
↑ Couzinet B, Thomas G, Thalabard JC, Brailly S, Schaison G (1989). "Effects of a pure antiandrogen on gonadotropin secretion in normal women and in polycystic ovarian disease". Fertil. Steril. 52 (1): 42–50. doi:10.1016/s0015-0282(16)60786-0. PMID 2744186.
↑ Namer M (1988). "Clinical applications of antiandrogens". J. Steroid Biochem. 31 (4B): 719–29. doi:10.1016/0022-4731(88)90023-4. PMID 2462132.
↑ Dole EJ, Holdsworth MT (1997). "Nilutamide: an antiandrogen for the treatment of prostate cancer". Ann Pharmacother. 31 (1): 65–75. doi:10.1177/106002809703100112. PMID 8997470. S2CID 20347526.
↑ Richard C. Dart (2004). Medical Toxicology. Lippincott Williams & Wilkins. pp. 521–. ISBN 978-0-7817-2845-4.
↑ Lisa M DeAngelis MD; Jerome B Posner MD (12 September 2008). Neurologic Complications of Cancer. Oxford University Press, USA. pp. 479–. ISBN 978-0-19-971055-3.
↑ Richard A. Lehne (2013). Pharmacology for Nursing Care. Elsevier Health Sciences. pp. 1297–. ISBN 978-1-4377-3582-6.
↑ Richard A. Lehne (2013). Pharmacology for Nursing Care. Elsevier Health Sciences. pp. 1297–. ISBN 978-1-4377-3582-6.
↑ Kenneth L. Becker (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 1196–. ISBN 978-0-7817-1750-2.
↑ Richard C. Dart (2004). Medical Toxicology. Lippincott Williams & Wilkins. pp. 521–. ISBN 978-0-7817-2845-4.
↑ Alan J. Wein; Louis R. Kavoussi; Andrew C. Novick; Alan W. Partin; Craig A. Peters (25 August 2011). Campbell-Walsh Urology: Expert Consult Premium Edition: Enhanced Online Features and Print, 4-Volume Set. Elsevier Health Sciences. pp. 2939–. ISBN 978-1-4160-6911-9.
↑ Jafri, Syed-Mohammed R. (2014). "Bicalutamide-induced hepatotoxicity: A rare adverse effect". American Journal of Case Reports. 15: 266–270. doi:10.12659/AJCR.890679. ISSN 1941-5923. PMC 4068966. PMID 24967002.
↑ Michael Boarder; David Newby; Phyllis Navti (25 March 2010). Pharmacology for Pharmacy and the Health Sciences: A Patient-centred Approach. OUP Oxford. pp. 632–. ISBN 978-0-19-955982-4.
↑ Dole EJ, Holdsworth MT (1997). "Nilutamide: an antiandrogen for the treatment of prostate cancer". Ann Pharmacother. 31 (1): 65–75. doi:10.1177/106002809703100112. PMID 8997470.
↑ {{cite book}}: Empty citation (help)
↑ Louis J Denis; Keith Griffiths; Amir V Kaisary; Gerald P Murphy (1 March 1999). Textbook of Prostate Cancer: Pathology, Diagnosis and Treatment: Pathology, Diagnosis and Treatment. CRC Press. pp. 280–. ISBN 978-1-85317-422-3.
↑ Vincent T. DeVita; Theodore S. Lawrence; Steven A. Rosenberg (18 March 2016). Prostate and Other Genitourinary Cancers: Cancer: Principles & Practice of Oncology. Wolters Kluwer Health. pp. 1006–. ISBN 978-1-4963-5421-1.
↑ Chawnshang Chang (1 January 2005). Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. World Scientific. pp. 11–. ISBN 978-981-256-920-2.
↑ Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships". Current Medicinal Chemistry. 7 (2): 211–247. doi:10.2174/0929867003375371. ISSN 0929-8673. PMID 10637363.
↑ Louis Denis (6 December 2012). Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment. Springer Science & Business Media. pp. 194–210. ISBN 978-3-642-45745-6.
↑ {{cite book}}: Empty citation (help)
↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 873–. ISBN 978-1-4757-2085-3.
↑ Labrie, Fernand; Lagacé, Lisette; Ferland, Louise; Kelly, Paul A.; Drouin, Jacques; Massicotte, Jocelyne; Bonne, Claude; Raynaud, Jean-Pierre; Dorrington, Jennifer H. (1978). "Interactions Between LHRH, Sex Steroids and "Inhibin" in the Control of LH and FSH Secretion". International Journal of Andrology. 1 (s2a): 81–101. doi:10.1111/j.1365-2605.1978.tb00008.x. ISSN 0105-6263.
↑ Raynaud JP, Bonne C, Bouton MM, Lagace L, Labrie F (1979). "Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues". J. Steroid Biochem. 11 (1A): 93–9. doi:10.1016/0022-4731(79)90281-4. PMID 385986.
↑ Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business Media. pp. 167–. ISBN 978-1-4612-4096-9.
↑ Bohl, C. E.; Gao, W.; Miller, D. D.; Bell, C. E.; Dalton, J. T. (2005). "Structural basis for antagonism and resistance of bicalutamide in prostate cancer". Proceedings of the National Academy of Sciences. 102 (17): 6201–6206. Bibcode:2005PNAS..102.6201B. doi:10.1073/pnas.0500381102. ISSN 0027-8424. PMC 1087923. PMID 15833816.
↑ "Nilutamide - AdisInsight".
↑ James Leonard Gulley (2011). Prostate Cancer. Demos Medical Publishing. pp. 81–. ISBN 978-1-935281-91-7.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

مطالعه بیشتر

Raynaud JP, Bonne C, Moguilewsky M, Lefebvre FA, Bélanger A, Labrie F (1984). "The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer: a review". Prostate. 5 (3): 299–311. doi:10.1002/pros.2990050307. PMID 6374639.
Moguilewsky M, Bertagna C, Hucher M (1987). "Pharmacological and clinical studies of the antiandrogen Anandron". J. Steroid Biochem. 27 (4–6): 871–5. doi:10.1016/0022-4731(87)90162-2. PMID 3320565.
Du Plessis DJ (1991). "Castration plus nilutamide vs castration plus placebo in advanced prostate cancer. A review". Urology. 37 (2 Suppl): 20–4. doi:10.1016/0090-4295(91)80097-q. PMID 1992599.
Creaven PJ, Pendyala L, Tremblay D (1991). "Pharmacokinetics and metabolism of nilutamide". Urology. 37 (2 Suppl): 13–9. doi:10.1016/0090-4295(91)80096-p. PMID 1992598.
Harris MG, Coleman SG, Faulds D, Chrisp P (1993). "Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer". Drugs Aging. 3 (1): 9–25. doi:10.2165/00002512-199303010-00002. PMID 8453188.
Dole EJ, Holdsworth MT (1997). "Nilutamide: an antiandrogen for the treatment of prostate cancer". Ann Pharmacother. 31 (1): 65–75. doi:10.1177/106002809703100112. PMID 8997470.
Iversen P, Melezinek I, Schmidt A (2001). "Nonsteroidal antiandrogens: a therapeutic option for patients with advanced prostate cancer who wish to retain sexual interest and function". BJU Int. 87 (1): 47–56. doi:10.1046/j.1464-410x.2001.00988.x. PMID 11121992.

[Nilandron-Label2-1] ttps://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020169s008lbl.pdf

[Elks20142-2] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 873–. ISBN 978-1-4757-2085-3.

[IndexNominum20002-3] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 737–. ISBN 978-3-88763-075-1.

[MortonHall20122-4] I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 199–. ISBN 978-94-011-4439-1.

[Drugs.com2-5] "Nilutamide".

[DenisGriffiths19992-6] Louis J Denis; Keith Griffiths; Amir V Kaisary; Gerald P Murphy (1 March 1999). Textbook of Prostate Cancer: Pathology, Diagnosis and Treatment: Pathology, Diagnosis and Treatment. CRC Press. pp. 280–. ISBN 978-1-85317-422-3.

[Denis2012a2-7] Louis Denis (6 December 2012). Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment. Springer Science & Business Media. pp. 194–210. ISBN 978-3-642-45745-6.

[KreukelsSteensma20132-8] Baudewijntje P.C. Kreukels; Thomas D. Steensma; Annelou L.C. de Vries (1 July 2013). Gender Dysphoria and Disorders of Sex Development: Progress in Care and Knowledge. Springer Science & Business Media. pp. 280–. ISBN 978-1-4614-7441-8.

[pmid27441862-9] Couzinet B, Thomas G, Thalabard JC, Brailly S, Schaison G (1989). "Effects of a pure antiandrogen on gonadotropin secretion in normal women and in polycystic ovarian disease". Fertil. Steril. 52 (1): 42–50. doi:10.1016/s0015-0282(16)60786-0. PMID 2744186.

[pmid24621322-10] Namer M (1988). "Clinical applications of antiandrogens". J. Steroid Biochem. 31 (4B): 719–29. doi:10.1016/0022-4731(88)90023-4. PMID 2462132.

[pmid89974702-11] Dole EJ, Holdsworth MT (1997). "Nilutamide: an antiandrogen for the treatment of prostate cancer". Ann Pharmacother. 31 (1): 65–75. doi:10.1177/106002809703100112. PMID 8997470. S2CID 20347526.

[Dart20042-12] Richard C. Dart (2004). Medical Toxicology. Lippincott Williams & Wilkins. pp. 521–. ISBN 978-0-7817-2845-4.

[MDMD20082-13] Lisa M DeAngelis MD; Jerome B Posner MD (12 September 2008). Neurologic Complications of Cancer. Oxford University Press, USA. pp. 479–. ISBN 978-0-19-971055-3.

[Lehne20132-14] Richard A. Lehne (2013). Pharmacology for Nursing Care. Elsevier Health Sciences. pp. 1297–. ISBN 978-1-4377-3582-6.

[Lehne20133-15] Richard A. Lehne (2013). Pharmacology for Nursing Care. Elsevier Health Sciences. pp. 1297–. ISBN 978-1-4377-3582-6.

[Becker20012-16] Kenneth L. Becker (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 1196–. ISBN 978-0-7817-1750-2.

[Dart20043-17] Richard C. Dart (2004). Medical Toxicology. Lippincott Williams & Wilkins. pp. 521–. ISBN 978-0-7817-2845-4.

[WeinKavoussi20112-18] Alan J. Wein; Louis R. Kavoussi; Andrew C. Novick; Alan W. Partin; Craig A. Peters (25 August 2011). Campbell-Walsh Urology: Expert Consult Premium Edition: Enhanced Online Features and Print, 4-Volume Set. Elsevier Health Sciences. pp. 2939–. ISBN 978-1-4160-6911-9.

[Jafri20142-19] Jafri, Syed-Mohammed R. (2014). "Bicalutamide-induced hepatotoxicity: A rare adverse effect". American Journal of Case Reports. 15: 266–270. doi:10.12659/AJCR.890679. ISSN 1941-5923. PMC 4068966. PMID 24967002.

[BoarderNewby20102-20] Michael Boarder; David Newby; Phyllis Navti (25 March 2010). Pharmacology for Pharmacy and the Health Sciences: A Patient-centred Approach. OUP Oxford. pp. 632–. ISBN 978-0-19-955982-4.

[pmid8997470-21] Dole EJ, Holdsworth MT (1997). "Nilutamide: an antiandrogen for the treatment of prostate cancer". Ann Pharmacother. 31 (1): 65–75. doi:10.1177/106002809703100112. PMID 8997470.

[Lehne2013-22] {{cite book}}: Empty citation (help)

[DenisGriffiths19993-23] Louis J Denis; Keith Griffiths; Amir V Kaisary; Gerald P Murphy (1 March 1999). Textbook of Prostate Cancer: Pathology, Diagnosis and Treatment: Pathology, Diagnosis and Treatment. CRC Press. pp. 280–. ISBN 978-1-85317-422-3.

[DeVitaLawrence20162-24] Vincent T. DeVita; Theodore S. Lawrence; Steven A. Rosenberg (18 March 2016). Prostate and Other Genitourinary Cancers: Cancer: Principles & Practice of Oncology. Wolters Kluwer Health. pp. 1006–. ISBN 978-1-4963-5421-1.

[Chang20052-25] Chawnshang Chang (1 January 2005). Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. World Scientific. pp. 11–. ISBN 978-981-256-920-2.

[SinghGauthier20002-26] Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships". Current Medicinal Chemistry. 7 (2): 211–247. doi:10.2174/0929867003375371. ISSN 0929-8673. PMID 10637363.

[Denis2012a3-27] Louis Denis (6 December 2012). Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment. Springer Science & Business Media. pp. 194–210. ISBN 978-3-642-45745-6.

[Denis2012a-28] {{cite book}}: Empty citation (help)

[Elks20143-29] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 873–. ISBN 978-1-4757-2085-3.

[LabrieLagacé19782-30] Labrie, Fernand; Lagacé, Lisette; Ferland, Louise; Kelly, Paul A.; Drouin, Jacques; Massicotte, Jocelyne; Bonne, Claude; Raynaud, Jean-Pierre; Dorrington, Jennifer H. (1978). "Interactions Between LHRH, Sex Steroids and "Inhibin" in the Control of LH and FSH Secretion". International Journal of Andrology. 1 (s2a): 81–101. doi:10.1111/j.1365-2605.1978.tb00008.x. ISSN 0105-6263.

[pmid3859862-31] Raynaud JP, Bonne C, Bouton MM, Lagace L, Labrie F (1979). "Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues". J. Steroid Biochem. 11 (1A): 93–9. doi:10.1016/0022-4731(79)90281-4. PMID 385986.

[Pavlik20122-32] Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business Media. pp. 167–. ISBN 978-1-4612-4096-9.

[BohlGao20052-33] Bohl, C. E.; Gao, W.; Miller, D. D.; Bell, C. E.; Dalton, J. T. (2005). "Structural basis for antagonism and resistance of bicalutamide in prostate cancer". Proceedings of the National Academy of Sciences. 102 (17): 6201–6206. Bibcode:2005PNAS..102.6201B. doi:10.1073/pnas.0500381102. ISSN 0027-8424. PMC 1087923. PMID 15833816.

[AdisInsight2-34] "Nilutamide - AdisInsight".

[Gulley20112-35] James Leonard Gulley (2011). Prostate Cancer. Demos Medical Publishing. pp. 81–. ISBN 978-1-935281-91-7.

[WHO22nd2-36] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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