کراتین ۲۰
ظاهر
KRT20 | |||||||||||||||||||||||||
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معینکنندهها | |||||||||||||||||||||||||
نامهای دیگر | KRT20, CD20, CK-20, CK20, K20, KRT21, keratin 20 | ||||||||||||||||||||||||
شناسههای بیرونی | OMIM: 608218 MGI: 1914059 HomoloGene: 56837 GeneCards: KRT20 | ||||||||||||||||||||||||
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همساختشناسی | |||||||||||||||||||||||||
گونهها | انسان | موش | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
آنسامبل | |||||||||||||||||||||||||
یونیپروت | |||||||||||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq (پروتئین) | |||||||||||||||||||||||||
موقعیت (UCSC) | ن/م | Chr : 99.32 – 99.33 Mb | |||||||||||||||||||||||
جستجوی PubMed | [۲] | [۳] | |||||||||||||||||||||||
ویکیداده | |||||||||||||||||||||||||
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![](http://upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Small_intestine_-_ck20_-_intermed_mag.jpg/220px-Small_intestine_-_ck20_-_intermed_mag.jpg)
کراتین ۲۰ (انگلیسی: Keratin 20) یک پروتئین است که در انسان توسط ژن «KRT20» کُدگذاری میشود.[۴][۵][۶] کراتین ۲۰ یک کراتین نوع ۱ و یک پروتئین سلولی اصلی در انتروسیتهای (سلولهای جذبی روده) بالغ و سلولهای جامی است و بهطور خاص در غشای مخاطی معده و رودهها یافت میشود.[۷]
در ایمونوهیستوشیمی، آنتیبادیهای کراتین ۲۰ برای تشخیص آدنوکارسینوم بافت پوششی (که بهطور معمول دارای کراتین ۲۰ هستند) کاربرد دارد. بهعنوان مثال این پروتئین در سرطان روده بزرگ، کارسینوم سلول ترانزیشنال و کارسینوم سلول مرکل دیده میشود، اما در سرطان ریه، سرطان پروستات و سرطان تخمدان غیرموسینی وجود ندارد. از این آنتیبادیها معمولاً در ترکیب با آنتیبادیهای کراتین ۷ جهت افتراق انواع سرطانهای بافت غدهای استفاده میشود.[۸]
منابع
[ویرایش]- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035775 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Moll R, Zimbelmann R, Goldschmidt MD, Keith M, Laufer J, Kasper M, Koch PJ, Franke WW (June 1993). "The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas". Differentiation. 53 (2): 75–93. doi:10.1111/j.1432-0436.1993.tb00648.x. PMID 8359595.
- ↑ Ye X, Li Y, Hou G, Liu Z, Chen T (May 2002). "[Significance of cytokeratin gene (CK-20 mRNA) expression in metastatic lymph nodes in colon carcinoma patients]". Zhonghua Zhong Liu Za Zhi (به چینی). 24 (3): 261–3. PMID 12515621.
- ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
- ↑ Moll R, Schiller DL, Franke WW (August 1990). "Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns". J. Cell Biol. 111 (2): 567–80. doi:10.1083/jcb.111.2.567. PMC 2116178. PMID 1696264.
- ↑ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 171–172. ISBN 1-84110-100-1.
برای مطالعهٔ بیشتر
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- Barbisan F, Santinelli A, Mazzucchelli R, et al. (2008). "Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur". Cancer. 112 (3): 636–44. doi:10.1002/cncr.23212. PMID 18072261. S2CID 22838425.
- Lagoudianakis EE, Kataki A, Manouras A, et al. (2009). "Detection of epithelial cells by RT-PCR targeting CEA, CK20, and TEM-8 in colorectal carcinoma patients using OncoQuick density gradient centrifugation system". J. Surg. Res. 155 (2): 183–90. doi:10.1016/j.jss.2007.10.013. PMID 19645077.
- Ishida M, Kushima R, Okabe H (2009). "Aberrant expression of class III beta-tubulin in basal cell carcinoma of the skin". Oncol. Rep. 22 (4): 733–7. doi:10.3892/or_00000494. PMID 19724850.
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در ویکیانبار پروندههایی دربارهٔ کراتین ۲۰ موجود است.