کراتین ۲۰

KRT20
معین‌کننده‌ها
نام‌های دیگر	KRT20, CD20, CK-20, CK20, K20, KRT21, keratin 20
شناسه‌های بیرونی	OMIM: 608218 MGI: 1914059 HomoloGene: 56837 GeneCards: KRT20
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	99,328,976 bp
هستی‌شناسی ژن
عملکرد ملکولی	• structural molecule activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • structural constituent of cytoskeleton;
ترکیبات سلولی	• سیتوپلاسم; • رشته‌های میانی; • سیتوزول;
فرایند زیستی	• intermediate filament organization; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • regulation of protein secretion; • keratinization; • cornification; • cellular response to starvation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	54474
	66809
	ENSG00000171431; ENSG00000263057
	ENSMUSG00000035775
	P35900
	Q9D312
	NM_019010
	NM_023256
	NP_061883
	NP_075745
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

کراتین ۲۰ (انگلیسی: Keratin 20) یک پروتئین است که در انسان توسط ژن «KRT20» کُدگذاری می‌شود.^[۴]^[۵]^[۶] کراتین ۲۰ یک کراتین نوع ۱ و یک پروتئین سلولی اصلی در انتروسیت‌های (سلول‌های جذبی روده) بالغ و سلول‌های جامی است و به‌طور خاص در غشای مخاطی معده و روده‌ها یافت می‌شود.^[۷]

در ایمونوهیستوشیمی، آنتی‌بادی‌های کراتین ۲۰ برای تشخیص آدنوکارسینوم بافت پوششی (که به‌طور معمول دارای کراتین ۲۰ هستند) کاربرد دارد. به‌عنوان مثال این پروتئین در سرطان روده بزرگ، کارسینوم سلول ترانزیشنال و کارسینوم سلول مرکل دیده می‌شود، اما در سرطان ریه، سرطان پروستات و سرطان تخمدان غیرموسینی وجود ندارد. از این آنتی‌بادی‌ها معمولاً در ترکیب با آنتی‌بادی‌های کراتین ۷ جهت افتراق انواع سرطان‌های بافت غده‌ای استفاده می‌شود.^[۸]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035775 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Moll R, Zimbelmann R, Goldschmidt MD, Keith M, Laufer J, Kasper M, Koch PJ, Franke WW (June 1993). "The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas". Differentiation. 53 (2): 75–93. doi:10.1111/j.1432-0436.1993.tb00648.x. PMID 8359595.
↑ Ye X, Li Y, Hou G, Liu Z, Chen T (May 2002). "[Significance of cytokeratin gene (CK-20 mRNA) expression in metastatic lymph nodes in colon carcinoma patients]". Zhonghua Zhong Liu Za Zhi (به چینی). 24 (3): 261–3. PMID 12515621.
↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
↑ Moll R, Schiller DL, Franke WW (August 1990). "Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns". J. Cell Biol. 111 (2): 567–80. doi:10.1083/jcb.111.2.567. PMC 2116178. PMID 1696264.
↑ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 171–172. ISBN 1-84110-100-1.

برای مطالعهٔ بیشتر[ویرایش]

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Wong CS, Cheung MT, Ma BB, et al. (2008). "Isolated tumor cells and circulating CK20 mRNA in pN0 colorectal cancer patients". Int. J. Surg. Pathol. 16 (2): 119–26. doi:10.1177/1066896907311901. PMID 18387990. S2CID 29407811.
Nishigami T, Onodera M, Torii I, et al. (2009). "Comparison between mucinous cystic neoplasm and intraductal papillary mucinous neoplasm of the branch duct type of the pancreas with respect to expression of CD10 and cytokeratin 20". Pancreas. 38 (5): 558–64. doi:10.1097/MPA.0b013e31819f3bd6. PMID 19287335. S2CID 30111257.
Saad RS, Silverman JF, Khalifa MA, Rowsell C (2009). "CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma". Appl. Immunohistochem. Mol. Morphol. 17 (3): 196–201. doi:10.1097/PAI.0b013e31819268f2. PMID 19098678. S2CID 37115618.
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González JJ, Bernardo CG, Sanz L, et al. (2007). "Mismatch repair protein MSH2, cytokeratin 18 and cytokeratin 20 expression: clinicopathological correlation and prognostic value in colorectal cancer patients". Hepatogastroenterology. 54 (80): 2266–71. PMID 18265645.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035775 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8359595-4] Moll R, Zimbelmann R, Goldschmidt MD, Keith M, Laufer J, Kasper M, Koch PJ, Franke WW (June 1993). "The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas". Differentiation. 53 (2): 75–93. doi:10.1111/j.1432-0436.1993.tb00648.x. PMID 8359595.

[pmid12515621-5] Ye X, Li Y, Hou G, Liu Z, Chen T (May 2002). "[Significance of cytokeratin gene (CK-20 mRNA) expression in metastatic lymph nodes in colon carcinoma patients]". Zhonghua Zhong Liu Za Zhi (به چینی). 24 (3): 261–3. PMID 12515621.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[pmid1696264-7] Moll R, Schiller DL, Franke WW (August 1990). "Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns". J. Cell Biol. 111 (2): 567–80. doi:10.1083/jcb.111.2.567. PMC 2116178. PMID 1696264.

[Leong-8] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 171–172. ISBN 1-84110-100-1.

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