TXK

TXK
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2DM0
معین‌کننده‌ها
نام‌های دیگر	TXK, BTKL, PSCTK5, PTK4, RLK, TKL, TXK tyrosine kinase
شناسه‌های بیرونی	OMIM: 600058 MGI: 102960 HomoloGene: 2497 GeneCards: TXK
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	72,910,120 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • DNA binding; • protein kinase activity; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • kinase activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein tyrosine kinase activity; • signaling receptor binding; • ATP binding; • non-membrane spanning protein tyrosine kinase activity;
ترکیبات سلولی	• سیتوپلاسم; • membrane; • extrinsic component of cytoplasmic side of plasma membrane; • پوسته یاخته; • هسته یاخته;
فرایند زیستی	• دگرگونی یاخته‌; • GO:0009373 regulation of transcription, DNA-templated; • adaptive immune response; • فسفرگیری; • tissue regeneration; • transmembrane receptor protein tyrosine kinase signaling pathway; • immune system process; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • GO:0032617 cytokine production; • positive regulation of interferon-gamma-mediated signaling pathway; • positive regulation of interferon-gamma production; • activation of phospholipase C activity; • transcription, DNA-templated; • protein phosphorylation; • regulation of cell population proliferation; • peptidyl-tyrosine autophosphorylation; • integrin-mediated signaling pathway; • protein autophosphorylation; • regulation of platelet activation; • T cell receptor signaling pathway; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7294
	22165
	ENSG00000074966
	ENSMUSG00000054892
	P42681
	P42682
	XM_011513747، XM_011513748، XM_017008581، XM_024454200، XM_047416122، XM_047416123، XM_047416125، XR_007057955 NM_003328، XM_011513747، XM_011513748، XM_017008581، XM_024454200، XM_047416122، XM_047416123، XM_047416125، XR_007057955
	NM_001289494، NM_001289495، NM_013698، XM_011240722، XM_036164998 NM_001122754، NM_001289494، NM_001289495، NM_013698، XM_011240722، XM_036164998
	XP_011512049، XP_011512050، XP_016864070، XP_016864071، XP_024309968 NP_003319، XP_011512049، XP_011512050، XP_016864070، XP_016864071، XP_024309968
	NP_001276423، NP_001276424، NP_038726، XP_011239024، XP_036020891 NP_001116226، NP_001276423، NP_001276424، NP_038726، XP_011239024، XP_036020891
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تیروزین-پروتئین کیناز TXK (انگلیسی: Tyrosine-protein kinase TXK) نام یک آنزیم است که در انسان توسط ژن «TXK» کُد می‌شود.^[۴]^[۵]^[۶]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000054892 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW (Nov 1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol Genet. 3 (6): 897–901. doi:10.1093/hmg/3.6.897. PMID 7951233.
↑ Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
↑ "Entrez Gene: TXK TXK tyrosine kinase".

مشارکت‌کنندگان ویکی‌پدیا. «TXK (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۹ نوامبر ۲۰۱۷.

بیشتر بخوانید

Suzuki N, Nara K, Suzuki T (2006). "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease". Clinical medicine & research. 4 (2): 147–51. doi:10.3121/cmr.4.2.147. PMC 1483892. PMID 16809408.
Ohta Y, Haire RN, Amemiya CT, et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID 8632917.
Wardenburg JB, Fu C, Jackman JK, et al. (1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function". J. Biol. Chem. 271 (33): 19641–4. doi:10.1074/jbc.271.33.19641. PMID 8702662.
Raab M, da Silva AJ, Findell PR, Rudd CE (1997). "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2". Immunity. 6 (2): 155–64. doi:10.1016/S1074-7613(00)80422-7. PMID 9047237.
Schneider H, Schwartzberg PL, Rudd CE (1998). "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4". Biochem. Biophys. Res. Commun. 252 (1): 14–9. doi:10.1006/bbrc.1998.9559. PMID 9813138.
Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". J. Exp. Med. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
Schneider H, Guerette B, Guntermann C, Rudd CE (2000). "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells". J. Biol. Chem. 275 (6): 3835–40. doi:10.1074/jbc.275.6.3835. PMID 10660534.
Chamorro M, Czar MJ, Debnath J, et al. (2004). "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk". BMC Immunol. 2: 3. doi:10.1186/1471-2172-2-3. PMC 31577. PMID 11353545.
Takeba Y, Nagafuchi H, Takeno M, et al. (2002). "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription". J. Immunol. 168 (5): 2365–70. doi:10.4049/jimmunol.168.5.2365. PMID 11859127.
Kashiwakura J, Suzuki N, Takeno M, et al. (2002). "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site". Biol. Pharm. Bull. 25 (6): 718–21. doi:10.1248/bpb.25.718. PMID 12081135.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rafalska I, Zhang Z, Benderska N, et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

این یک مقالهٔ خرد آنزیم ، پروتئین یا زیست‌مولکول است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000054892 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_7951233-4] Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW (Nov 1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol Genet. 3 (6): 897–901. doi:10.1093/hmg/3.6.897. PMID 7951233.

[pmid_7528718-5] Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.

[entrez-6] "Entrez Gene: TXK TXK tyrosine kinase".

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]