SP-A1

SFTPA1
معین‌کننده‌ها
نام‌های دیگر	SFTPA1, COLEC4, PSAP, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1, SPA, SPA1, surfactant protein A1, SP-A1 beta, SP-A1 delta, SP-A1 gamma, SP-A1 epsilon, ILD1
شناسه‌های بیرونی	OMIM: 178630 MGI: 109518 HomoloGene: 3946 GeneCards: SFTPA1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	40,858,409 bp
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • carbohydrate binding; • lipid transporter activity; • lipopolysaccharide binding; • monosaccharide binding;
ترکیبات سلولی	• extracellular region; • clathrin-coated endocytic vesicle; • کلاژن; • lamellar granule; • endoplasmic reticulum membrane; • extracellular space; • multivesicular body; • rough endoplasmic reticulum;
فرایند زیستی	• respiratory gaseous exchange by respiratory system; • lipid transport; • toll-like receptor signaling pathway; • opsonization; • surfactant homeostasis; • positive regulation of phagocytosis; • GO:0007571 developmental process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	653509
	20387
	ENSG00000122852
	ENSMUSG00000021789
	Q8IWL2
	P35242; Q9CQI1
	NM_001093770، NM_001164644، NM_001164645، NM_001164646، NM_001164647، NM_005411، XM_005270062 XM_006717953، NM_001093770، NM_001164644، NM_001164645، NM_001164646، NM_001164647، NM_005411، XM_005270062
	NM_023134
	NP_001158116، NP_001158117، NP_001158118، NP_001158119، NP_005402، XP_005270119، XP_006718016 NP_001087239، NP_001158116، NP_001158117، NP_001158118، NP_001158119، NP_005402، XP_005270119، XP_006718016
	NP_075623
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

سورفکتانت پروتئین A1 (انگلیسی: Surfactant protein A1) که با نام سورفکتانت پروتئین A1 مربوط به ریه هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «SFTPA1» کُدگذاری می‌شود^[۴]^[۵] که بر روی بازوی بلند کروموزوم ۱۰ جای دارد.

این پروتئین بیشتر در سلول‌های نوع ۲ کیسه‌های هوایی در ریه‌ها ساخته می شود و جزئی از سورفکتانت ریوی است. یکی از وظایف این مولکول، کاهش کشش سطحی در کیسه‌های هوایی، جهت جلوگیری از فروخوابیدگی ریه‌ها در جریان بازدم است. تغییر در ترکیب سورفکتانت ریوی، عملکرد آنرا تغییر داده و موجب بیماری تنفسی می‌شود.^[۶]^[۷]^[۸]^[۹]

این پروتئین همچنین در تعدیل دستگاه ایمنی ذاتی و فرایند التهاب نقش دارد.^[۱۰]

اهمیت بالینی[ویرایش]

کاهش سطح این مولکول موجب بروز سندرم زجر تنفسی نوزادان در نوزادان زودرس می‌شود که پیش از موعد به‌دنیا آمده‌اند.^[۱۱]

تعییر در ژن «SFTPA1» موجب بروز فیبروز ریوی ایدیوپاتیک هم می‌گردد.^[۱۲]

تغییرات نسبت SP-A1 به SP-A در بیماری‌های آسم، فیبروز سیستیک و همچنین با افزایش سن مشاهده شده‌است.^[۱۳]^[۱۴]

متیلاسیون توالی پروموتر در این ژن در بافت‌های سرطان ریه یافت شده‌است.^[۱۵]^[۱۶]

جستارهای وابسته[ویرایش]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021789 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Surfactant protein A1".
↑ Silveyra P, Floros J (Dec 2013). "Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2". Gene. 531 (2): 126–32. doi:10.1016/j.gene.2012.09.111. PMC 3570704. PMID 23069847.
↑ Silveyra P, Floros J (2012). "Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury". Frontiers in Bioscience. 17: 407–29. doi:10.2741/3935. PMC 3635489. PMID 22201752.
↑ Floros J, Kala P (1998). "Surfactant proteins: molecular genetics of neonatal pulmonary diseases". Annual Review of Physiology. 60: 365–84. doi:10.1146/annurev.physiol.60.1.365. PMID 9558469.
↑ Floros J, Wang G (May 2001). "A point of view: quantitative and qualitative imbalance in disease pathogenesis; pulmonary surfactant protein A genetic variants as a model". Comparative Biochemistry and Physiology A. 129 (1): 295–303. doi:10.1016/S1095-6433(01)00325-7. PMID 11369553.
↑ Whitsett JA, Wert SE, Weaver TE (2010). "Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease". Annual Review of Medicine. 61: 105–19. doi:10.1146/annurev.med.60.041807.123500. PMC 4127631. PMID 19824815.
↑ Perez-Gil J, Weaver TE (Jun 2010). "Pulmonary surfactant pathophysiology: current models and open questions". Physiology. 25 (3): 132–41. doi:10.1152/physiol.00006.2010. PMID 20551227.
↑ deMello DE, Heyman S, Phelps DS, Floros J (May 1993). "Immunogold localization of SP-A in lungs of infants dying from respiratory distress syndrome". The American Journal of Pathology. 142 (5): 1631–40. PMC 1886897. PMID 8494055.
↑ Selman M, King TE, Pardo A (Jan 2001). "Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy". Annals of Internal Medicine. 134 (2): 136–51. doi:10.7326/0003-4819-134-2-200101160-00015. PMID 11177318.
↑ Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J (May 2007). "Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health". American Journal of Physiology. Lung Cellular and Molecular Physiology. 292 (5): L1052–63. doi:10.1152/ajplung.00249.2006. PMID 17189324.
↑ Wang Y, Voelker DR, Lugogo NL, Wang G, Floros J, Ingram JL, Chu HW, Church TD, Kandasamy P, Fertel D, Wright JR, Kraft M (Oct 2011). "Surfactant protein A is defective in abrogating inflammation in asthma". American Journal of Physiology. Lung Cellular and Molecular Physiology. 301 (4): L598–606. doi:10.1152/ajplung.00381.2010. PMC 3191759. PMID 21784968.
↑ Vaid M, Floros J (Jan 2009). "Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review)". Oncology Reports. 21 (1): 3–11. doi:10.3892/or_00000182. PMC 2899699. PMID 19082436.
↑ Lin Z, Thomas NJ, Bibikova M, Seifart C, Wang Y, Guo X, Wang G, Vollmer E, Goldmann T, Garcia EW, Zhou L, Fan JB, Floros J (Jul 2007). "DNA methylation markers of surfactant proteins in lung cancer". International Journal of Oncology. 31 (1): 181–91. doi:10.3892/ijo.31.1.181. PMID 17549420.

مشارکت‌کنندگان ویکی‌پدیا. «Surfactant protein A1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ نوامبر ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

Lu J (Jun 1997). "Collectins: collectors of microorganisms for the innate immune system". BioEssays. 19 (6): 509–18. doi:10.1002/bies.950190610. PMID 9204768.
Floros J, Hoover RR (Nov 1998). "Genetics of the hydrophilic surfactant proteins A and D". Biochimica et Biophysica Acta. 1408 (2–3): 312–22. doi:10.1016/S0925-4439(98)00077-5. PMID 9813381.
Khubchandani KR, Snyder JM (Jan 2001). "Surfactant protein A (SP-A): the alveolus and beyond". FASEB Journal. 15 (1): 59–69. CiteSeerX 10.1.1.326.5508. doi:10.1096/fj.00-0318rev. PMID 11149893.
Katyal SL, Singh G, Locker J (Apr 1992). "Characterization of a second human pulmonary surfactant-associated protein SP-A gene". American Journal of Respiratory Cell and Molecular Biology. 6 (4): 446–52. doi:10.1165/ajrcmb/6.4.446. PMID 1372511.
Childs RA, Wright JR, Ross GF, Yuen CT, Lawson AM, Chai W, Drickamer K, Feizi T (May 1992). "Specificity of lung surfactant protein SP-A for both the carbohydrate and the lipid moieties of certain neutral glycolipids". The Journal of Biological Chemistry. 267 (14): 9972–9. PMID 1577827.
Endo H, Oka T (Jun 1991). "An immunohistochemical study of bronchial cells producing surfactant protein A in the developing human fetal lung". Early Human Development. 25 (3): 149–56. doi:10.1016/0378-3782(91)90111-F. PMID 1935736.
Voss T, Melchers K, Scheirle G, Schäfer KP (Jan 1991). "Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A". American Journal of Respiratory Cell and Molecular Biology. 4 (1): 88–94. doi:10.1165/ajrcmb/4.1.88. PMID 1986781.
Haagsman HP, White RT, Schilling J, Lau K, Benson BJ, Golden J, Hawgood S, Clements JA (Dec 1989). "Studies of the structure of lung surfactant protein SP-A". The American Journal of Physiology. 257 (6 Pt 1): L421–9. doi:10.1152/ajplung.1989.257.6.L421. PMID 2610270.
Fisher JH, Kao FT, Jones C, White RT, Benson BJ, Mason RJ (Jun 1987). "The coding sequence for the 32,000-dalton pulmonary surfactant-associated protein A is located on chromosome 10 and identifies two separate restriction-fragment-length polymorphisms". American Journal of Human Genetics. 40 (6): 503–11. PMC 1684155. PMID 2884868.
White RT, Damm D, Miller J, Spratt K, Schilling J, Hawgood S, Benson B, Cordell B (1985). "Isolation and characterization of the human pulmonary surfactant apoprotein gene". Nature. 317 (6035): 361–3. doi:10.1038/317361a0. PMID 2995821.
Floros J, Steinbrink R, Jacobs K, Phelps D, Kriz R, Recny M, Sultzman L, Jones S, Taeusch HW, Frank HA (Jul 1986). "Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein". The Journal of Biological Chemistry. 261 (19): 9029–33. PMID 3755136.
Schaeffer E, Guillou F, Part D, Zakin MM (Nov 1993). "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells". The Journal of Biological Chemistry. 268 (31): 23399–408. PMID 8226864.
Khoor A, Gray ME, Hull WM, Whitsett JA, Stahlman MT (Sep 1993). "Developmental expression of SP-A and SP-A mRNA in the proximal and distal respiratory epithelium in the human fetus and newborn". The Journal of Histochemistry and Cytochemistry. 41 (9): 1311–9. doi:10.1177/41.9.8354874. PMID 8354874.
Strayer DS, Yang S, Jerng HH (Sep 1993). "Surfactant protein A-binding proteins. Characterization and structures". The Journal of Biological Chemistry. 268 (25): 18679–84. PMID 8360162.
Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (Aug 1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster". Genomics. 17 (2): 294–8. doi:10.1006/geno.1993.1324. PMID 8406480.
deMello DE, Heyman S, Phelps DS, Floros J (May 1993). "Immunogold localization of SP-A in lungs of infants dying from respiratory distress syndrome". The American Journal of Pathology. 142 (5): 1631–40. PMC 1886897. PMID 8494055.
Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL (Jul 1996). "Purification of a cell-surface receptor for surfactant protein A". The Journal of Biological Chemistry. 271 (27): 16375–83. doi:10.1074/jbc.271.27.16375. PMID 8663107.
Planer BC, Ning Y, Kumar SA, Ballard PL (Aug 1997). "Transcriptional regulation of surfactant proteins SP-A and SP-B by phorbol ester". Biochimica et Biophysica Acta. 1353 (2): 171–9. doi:10.1016/S0167-4781(97)00070-5. PMID 9294011.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021789 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: Surfactant protein A1".

[pmid23069847-5] Silveyra P, Floros J (Dec 2013). "Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2". Gene. 531 (2): 126–32. doi:10.1016/j.gene.2012.09.111. PMC 3570704. PMID 23069847.

[Silveyra_Floros_2012a-6] Silveyra P, Floros J (2012). "Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury". Frontiers in Bioscience. 17: 407–29. doi:10.2741/3935. PMC 3635489. PMID 22201752.

[Floros_and_Kala_1998-7] Floros J, Kala P (1998). "Surfactant proteins: molecular genetics of neonatal pulmonary diseases". Annual Review of Physiology. 60: 365–84. doi:10.1146/annurev.physiol.60.1.365. PMID 9558469.

[Floros_and_Wang_2001-8] Floros J, Wang G (May 2001). "A point of view: quantitative and qualitative imbalance in disease pathogenesis; pulmonary surfactant protein A genetic variants as a model". Comparative Biochemistry and Physiology A. 129 (1): 295–303. doi:10.1016/S1095-6433(01)00325-7. PMID 11369553.

[Whitsett_et_al._2010-9] Whitsett JA, Wert SE, Weaver TE (2010). "Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease". Annual Review of Medicine. 61: 105–19. doi:10.1146/annurev.med.60.041807.123500. PMC 4127631. PMID 19824815.

[Perez-Gil_et_al._2010-10] Perez-Gil J, Weaver TE (Jun 2010). "Pulmonary surfactant pathophysiology: current models and open questions". Physiology. 25 (3): 132–41. doi:10.1152/physiol.00006.2010. PMID 20551227.

[De_Mello_et_al._1993-11] Mello DE, Heyman S, Phelps DS, Floros J (May 1993). "Immunogold localization of SP-A in lungs of infants dying from respiratory distress syndrome". The American Journal of Pathology. 142 (5): 1631–40. PMC 1886897. PMID 8494055.

[pmid11177318-12] Selman M, King TE, Pardo A (Jan 2001). "Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy". Annals of Internal Medicine. 134 (2): 136–51. doi:10.7326/0003-4819-134-2-200101160-00015. PMID 11177318.

[Tagaram_et_al._2007-13] Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J (May 2007). "Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health". American Journal of Physiology. Lung Cellular and Molecular Physiology. 292 (5): L1052–63. doi:10.1152/ajplung.00249.2006. PMID 17189324.

[Wang_et_al._2011-14] Wang Y, Voelker DR, Lugogo NL, Wang G, Floros J, Ingram JL, Chu HW, Church TD, Kandasamy P, Fertel D, Wright JR, Kraft M (Oct 2011). "Surfactant protein A is defective in abrogating inflammation in asthma". American Journal of Physiology. Lung Cellular and Molecular Physiology. 301 (4): L598–606. doi:10.1152/ajplung.00381.2010. PMC 3191759. PMID 21784968.

[pmid19082436-15] Vaid M, Floros J (Jan 2009). "Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review)". Oncology Reports. 21 (1): 3–11. doi:10.3892/or_00000182. PMC 2899699. PMID 19082436.

[pmid17549420-16] Lin Z, Thomas NJ, Bibikova M, Seifart C, Wang Y, Guo X, Wang G, Vollmer E, Goldmann T, Garcia EW, Zhou L, Fan JB, Floros J (Jul 2007). "DNA methylation markers of surfactant proteins in lung cancer". International Journal of Oncology. 31 (1): 181–91. doi:10.3892/ijo.31.1.181. PMID 17549420.

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