CD69

CD69
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1E87, 1E8I, 1FM5, 3CCK, 3HUP
معین‌کننده‌ها
نام‌های دیگر	CD69, AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3, CD69 molecule
شناسه‌های بیرونی	OMIM: 107273 MGI: 88343 HomoloGene: 128584 GeneCards: CD69
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	129,252,399 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• calcium ion binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • transmembrane signaling receptor activity; • carbohydrate binding; • protein homodimerization activity;
ترکیبات سلولی	• integral component of membrane; • integral component of plasma membrane; • membrane; • external side of plasma membrane; • GO:0009327 protein-containing complex; • cell surface;
فرایند زیستی	• GO:0072468 ورارسانی پیام;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	969
	12515
	ENSG00000110848
	ENSMUSG00000030156
	Q07108
	P37217
	NM_001781، NR_026671 NR_026672، NM_001781، NR_026671
	XM_006505463 NM_001033122، XM_006505463
	NP_001772
	XP_006505526 NP_001028294، XP_006505526
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

مجموعه تمایزی ۶۹ (انگلیسی: Cluster of Differentiation ۶۹) یک پروتئین تراپوسته‌ای از نوع لکتین نوع سی است که در انسان توسط ژن «CD69» کُدگذاری می‌شود.

این پروتئین، یکی از نخستین نشانگرهای فعال سازی است که بر روی سطح سلول‌های خون‌ساز اولیه، لنفوسیت‌های تی و بسیاری دیگر از انواع سلول‌های سیستم ایمنی بدن ظاهر می‌شود.^[۴] این مولکول همچنین در تمایز لنفوسیت‌های تی و نگه‌داشتن آنان در درون احشاء لنفاوی نقش دارد.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030156 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ziegler SF, Ramsdell F, Alderson MR (September 1994). "The activation antigen CD69". Stem Cells. 12 (5): 456–65. doi:10.1002/stem.5530120502. PMID 7804122.

مشارکت‌کنندگان ویکی‌پدیا. «CD69». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

Li Q, Lan X, Han X, Wang J (January 2019). "Expression of Tmem119/Sall1 and Ccr2/CD69 in FACS-Sorted Microglia- and Monocyte/Macrophage-Enriched Cell Populations After Intracerebral Hemorrhage". Front Cell Neurosci. 12: 520. doi:10.3389/fncel.2018.00520. PMC 6333739. PMID 30687011.
Cambiaggi C, Scupoli MT, Cestari T, Gerosa F, Carra G, Tridente G, Accolla RS (1992). "Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12". Immunogenetics. 36 (2): 117–20. doi:10.1007/BF00215288. PMID 1612643.
López-Cabrera M, Muñoz E, Blázquez MV, Ursa MA, Santis AG, Sánchez-Madrid F (September 1995). "Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements". The Journal of Biological Chemistry. 270 (37): 21545–51. doi:10.1074/jbc.270.37.21545. PMID 7665567.
Bezouska K, Nepovím A, Horváth O, Pospísil M, Hamann J, Feizi T (March 1995). "CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein". Biochemical and Biophysical Research Communications. 208 (1): 68–74. doi:10.1006/bbrc.1995.1306. PMID 7887967.
Santis AG, López-Cabrera M, Hamann J, Strauss M, Sánchez-Madrid F (July 1994). "Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors". European Journal of Immunology. 24 (7): 1692–7. doi:10.1002/eji.1830240735. PMID 8026529.
Ziegler SF, Ramsdell F, Hjerrild KA, Armitage RJ, Grabstein KH, Hennen KB, Farrah T, Fanslow WC, Shevach EM, Alderson MR (July 1993). "Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens". European Journal of Immunology. 23 (7): 1643–8. doi:10.1002/eji.1830230737. PMID 8100776.
López-Cabrera M, Santis AG, Fernández-Ruiz E, Blacher R, Esch F, Sánchez-Mateos P, Sánchez-Madrid F (August 1993). "Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors". The Journal of Experimental Medicine. 178 (2): 537–47. doi:10.1084/jem.178.2.537. PMC 2191117. PMID 8340758.
Hamann J, Fiebig H, Strauss M (June 1993). "Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain". Journal of Immunology. 150 (11): 4920–7. PMID 8496594.
Krowka JF, Cuevas B, Maron DC, Steimer KS, Ascher MS, Sheppard HW (January 1996). "Expression of CD69 after in vitro stimulation: a rapid method for quantitating impaired lymphocyte responses in HIV-infected individuals". Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 11 (1): 95–104. doi:10.1097/00042560-199601010-00013. PMID 8528739.
Iafrate AJ, Bronson S, Skowronski J (February 1997). "Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling". The EMBO Journal. 16 (4): 673–84. doi:10.1093/emboj/16.4.673. PMC 1169669. PMID 9049297.
Vance BA, Bennett MJ, Ward Y, Gress RG, Kearse KP (August 1999). "Distinct but dispensable N-glycosylation of human CD69 proteins". Archives of Biochemistry and Biophysics. 368 (2): 214–20. doi:10.1006/abbi.1999.1322. PMID 10441371.
Blázquez MV, Macho A, Ortiz C, Lucena C, López-Cabrera M, Sánchez-Madrid F, Muñoz E (September 1999). "Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins". AIDS Research and Human Retroviruses. 15 (13): 1209–18. doi:10.1089/088922299310304. PMID 10480634.
Llera AS, Viedma F, Sánchez-Madrid F, Tormo J (March 2001). "Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69". The Journal of Biological Chemistry. 276 (10): 7312–9. doi:10.1074/jbc.M008573200. PMID 11036086.
Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA (December 2000). "Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells". Biochemistry. 39 (48): 14779–86. doi:10.1021/bi0018180. PMID 11101293.
Liu X, Schrager JA, Lange GD, Marsh JW (August 2001). "HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations". The Journal of Biological Chemistry. 276 (35): 32763–70. doi:10.1074/jbc.M101025200. PMID 11438519.
Diament D, Brunialti MK, Romero EC, Kallas EG, Salomao R (April 2002). "Peripheral blood mononuclear cell activation induced by Leptospira interrogans glycolipoprotein". Infection and Immunity. 70 (4): 1677–83. doi:10.1128/IAI.70.4.1677-1683.2002. PMC 127819. PMID 11895929.
Yoshimura C, Yamaguchi M, Iikura M, Izumi S, Kudo K, Nagase H, Ishii A, Walls AF, Ra C, Iwata T, Igarashi T, Yamamoto K, Hirai K (May 2002). "Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3". The Journal of Allergy and Clinical Immunology. 109 (5): 817–23. doi:10.1067/mai.2002.123532. PMID 11994706.
Pisegna S, Zingoni A, Pirozzi G, Cinque B, Cifone MG, Morrone S, Piccoli M, Frati L, Palmieri G, Santoni A (July 2002). "Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells". Journal of Immunology. 169 (1): 68–74. doi:10.4049/jimmunol.169.1.68. PMID 12077230.
Liu CC, Huang KJ, Lin YS, Yeh TM, Liu HS, Lei HY (October 2002). "Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection". Journal of Medical Virology. 68 (2): 241–52. doi:10.1002/jmv.10198. PMID 12210415.
Foerster M, Haefner D, Kroegel C (October 2002). "Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling". Scandinavian Journal of Immunology. 56 (4): 417–28. doi:10.1046/j.1365-3083.2002.01111.x. PMID 12234263.
Weigel G, Griesmacher A, Karimi A, Zuckermann AO, Grimm M, Mueller MM (October 2002). "Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients". The Journal of Heart and Lung Transplantation. 21 (10): 1074–9. doi:10.1016/S1053-2498(02)00440-0. PMID 12398872.