PYGO2

PYGO2
ساختارهای موجود PDB جستجوی یونی‌پروت انسان: PDBe RCSB فهرست شناسه‌های PDB 2XB1, 4UP0, 4UP5
معین‌کننده‌ها
نام‌های دیگر	PYGO2, 1190004M21Rik, pygopus family PHD finger 2
شناسه‌های بیرونی	OMIM: 606903 MGI: 1916161 HomoloGene: 44519 GeneCards: PYGO2
موقعیت ژن (موش) کروموزوم کروموزوم ۳ (موش) نوار 3|3 F1 شروع 89,337,521 bp پایان 89,342,435 bp
هستی‌شناسی ژن عملکرد ملکولی • GO:0031493 histone binding • metal ion binding • GO:0001948، GO:0016582 پیوند پروتئینی • chromatin binding • histone acetyltransferase regulator activity ترکیبات سلولی • نوکلئوپلاسم • هسته یاخته • beta-catenin-TCF complex فرایند زیستی • roof of mouth development • regulation of histone H3-K4 methylation • in utero embryonic development • regulation of mammary gland epithelial cell proliferation • positive regulation of chromatin binding • mammary gland development • brain development • lens development in camera-type eye • developmental growth • regulation of histone acetylation • spermatid development • canonical Wnt signaling pathway • beta-catenin-TCF complex assembly • kidney development • spermatid nucleus differentiation • post-embryonic development • Wnt signaling pathway منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	90780	68911
آنسامبل	ENSG00000163348	ENSMUSG00000047824
یونی‌پروت	Q9BRQ0	ن/م
RefSeq (mRNA)	NM_138300	NM_001293766، NM_001293767، NM_001293768، NM_026869، XM_030252784، XM_030252785 NM_001293763، NM_001293766، NM_001293767، NM_001293768، NM_026869، XM_030252784، XM_030252785
RefSeq (پروتئین)	NP_612157	ن/م
موقعیت (UCSC)	ن/م	Chr : 89.34 – 89.34 Mb
جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

همولوگ ۲ پیگوپوس پروتئینی است که در انسان توسط ژن PYGO2 کدگذاری می‌شود.

جهت مطالعه

• Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex" (PDF). Cell. 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446. S2CID 16720801. Archived from the original (PDF) on 26 September 2021. Retrieved 29 July 2022.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447. S2CID 6880212.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Popadiuk CM, Xiong J, Wells MG, et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer". Clin. Cancer Res. 12 (7 Pt 1): 2216–23. doi:10.1158/1078-0432.CCR-05-2433. PMID 16609037. S2CID 3260972.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272. S2CID 17642255.
• Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer". Int. J. Oncol. 30 (2): 357–63. doi:10.3892/ijo.30.2.357 (inactive 28 February 2022). PMID 17203217.{{cite journal}}: CS1 maint: DOI inactive as of فوریه 2022 (link)