NLGN3

NLGN3
معین‌کننده‌ها
نام‌های دیگر	NLGN3, HNL3, neuroligin 3
شناسه‌های بیرونی	OMIM: 300336 MGI: 2444609 HomoloGene: 23133 GeneCards: NLGN3
موقعیت ژن (انسان)
کروموزوم	کروموزوم X (انسان)
پایان	71,175,255 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم X (موش)
پایان	100,369,569 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• scaffold protein binding; • neurexin family protein binding; • GO:0004091 carboxylic ester hydrolase activity; • cell adhesion molecule binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • signaling receptor activity;
ترکیبات سلولی	• integral component of membrane; • membrane; • cell surface; • سیناپس; • پیوند میان‌یاخته‌ای; • endocytic vesicle; • سیناپس تحریکی; • پوسته یاخته; • integral component of plasma membrane; • integral component of postsynaptic membrane; • spanning component of membrane; • presynapse; • symmetric, GABA-ergic, inhibitory synapse; • asymmetric, glutamatergic, excitatory synapse;
فرایند زیستی	• regulation of AMPA receptor activity; • positive regulation of synaptic vesicle clustering; • رفتار اجتماعی; • rhythmic synaptic transmission; • regulation of NMDA receptor activity; • regulation of synaptic transmission, glutamatergic; • excitatory postsynaptic potential; • positive regulation of AMPA receptor activity; • synapse organization; • negative regulation of excitatory postsynaptic potential; • modulation of chemical synaptic transmission; • regulation of respiratory gaseous exchange by nervous system process; • axon extension; • یادگیری; • تقویت طولانی مدت; • vocalization behavior; • negative regulation of dendritic spine morphogenesis; • neuron cell-cell adhesion; • regulation of dendritic spine morphogenesis; • receptor-mediated endocytosis; • چسبندگی سلولی; • oligodendrocyte differentiation; • regulation of terminal button organization; • adult behavior; • positive regulation of excitatory postsynaptic potential; • positive regulation of synaptic transmission, glutamatergic; • regulation of long-term synaptic potentiation; • یادگیری بصری; • inhibitory postsynaptic potential; • positive regulation of synapse assembly; • سیناپتوژنز; • synaptic vesicle endocytosis; • postsynaptic membrane assembly; • presynaptic membrane assembly; • presynapse assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	54413
	245537
	ENSG00000196338
	ENSMUSG00000031302
	Q9NZ94
	Q8BYM5
	NM_018977، NM_181303، XM_006724662، XM_006724663، XM_011530974، NM_001321276، XM_017029597، XM_047442185، XM_047442186 NM_001166660، NM_018977، NM_181303، XM_006724662، XM_006724663، XM_011530974، NM_001321276، XM_017029597، XM_047442185، XM_047442186
	NM_172932
	NP_001308205، NP_061850، NP_851820، XP_006724725، XP_006724726، XP_011529276، XP_016885086 NP_001160132، NP_001308205، NP_061850، NP_851820، XP_006724725، XP_006724726، XP_011529276، XP_016885086; NP_001160132.1
	NP_766520
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

نورولایگین-۳ (انگلیسی: Neuroligin-3) یک پروتئین است که در انسان توسط ژن «NLGN3» کُدگذاری می‌شود.^[۵]^[۶]^[۷]

این پروتئین در شکل‌گیری و بازسازی سیناپس‌های دستگاه عصبی مرکزی نقش دارد. جهش در این ژن احتمالاً با بروز «اختلالات طیف اوتیسم» در ارتباط است.

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000196338 - Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000031302 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
↑ "Entrez Gene: NLGN3 neuroligin 3".

مشارکت‌کنندگان ویکی‌پدیا. «NLGN3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ مه ۲۰۱۸.

بیشتر بخوانید[ویرایش]

Missler M, Fernandez-Chacon R, Südhof TC (1998). "The making of neurexins". J. Neurochem. 71 (4): 1339–47. doi:10.1046/j.1471-4159.1998.71041339.x. PMID 9751164.
Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032–9. doi:10.1074/jbc.272.41.26032. PMID 9325340.
Gilbert M, Smith J, Roskams AJ, Auld VJ (2001). "Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia". Glia. 34 (3): 151–64. doi:10.1002/glia.1050. PMID 11329178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Vincent JB, Kolozsvari D, Roberts WS, et al. (2005). "Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 82–4. doi:10.1002/ajmg.b.30069. PMID 15274046.
Gauthier J, Bonnel A, St-Onge J, et al. (2005). "NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 132 (1): 74–5. doi:10.1002/ajmg.b.30066. PMID 15389766.
Yan J, Oliveira G, Coutinho A, et al. (2005). "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients". Mol. Psychiatry. 10 (4): 329–32. doi:10.1038/sj.mp.4001629. PMID 15622415.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Blasi F, Bacchelli E, Pesaresi G, et al. (2006). "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (3): 220–1. doi:10.1002/ajmg.b.30287. PMID 16508939.
Talebizadeh Z, Lam DY, Theodoro MF, et al. (2006). "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism". J. Med. Genet. 43 (5): e21. doi:10.1136/jmg.2005.036897. PMC 2564526. PMID 16648374.
Yamakawa H, Oyama S, Mitsuhashi H, et al. (2007). "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations". Biochem. Biophys. Res. Commun. 355 (1): 41–6. doi:10.1016/j.bbrc.2007.01.127. PMID 17292328.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000196338 - Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000031302 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10767552-5] Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.

[pmid10819331-6] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[entrez-7] "Entrez Gene: NLGN3 neuroligin 3".

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