HDAC1

HDAC1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4BKX, 5ICN
معین‌کننده‌ها
نام‌های دیگر	HDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
شناسه‌های بیرونی	OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	129,436,506 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • NAD-dependent histone deacetylase activity (H3-K14 specific); • GO:0001106 transcription corepressor activity; • histone deacetylase activity; • protein N-terminus binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • protein deacetylase activity; • histone deacetylase binding; • GO:0000975 transcription cis-regulatory region binding; • NF-kappaB binding; • deacetylase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • nucleosomal DNA binding; • enzyme binding; • hydrolase activity; • core promoter sequence-specific DNA binding; • p53 binding; • transcription factor binding; • RNA polymerase II core promoter sequence-specific DNA binding; • DNA binding; • chromatin binding; • Krueppel-associated box domain binding; • E-box binding; • promoter-specific chromatin binding;
ترکیبات سلولی	• سیتوپلاسم; • NuRD complex; • سیتوزول; • histone deacetylase complex; • Sin3 complex; • نوکلئوپلاسم; • هسته یاخته; • کروماتین; • GO:0035328 heterochromatin; • transcription regulator complex; • transcription repressor complex; • GO:0009327 protein-containing complex; • neuronal cell body; • Sin3-type complex;
فرایند زیستی	• hair follicle placode formation; • epidermal cell differentiation; • chromatin remodeling; • GO:0009373 regulation of transcription, DNA-templated; • rhythmic process; • negative regulation of androgen receptor signaling pathway; • embryonic digit morphogenesis; • negative regulation of apoptotic process; • انعقاد خون; • GO:1901227 negative regulation of transcription by RNA polymerase II; • eyelid development in camera-type eye; • circadian regulation of gene expression; • negative regulation of gene expression; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • odontogenesis of dentin-containing tooth; • protein deacetylation; • histone H4 deacetylation; • fungiform papilla formation; • negative regulation of myotube differentiation; • GO:0022415 viral process; • histone deacetylation; • negative regulation of canonical Wnt signaling pathway; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • regulation of signal transduction by p53 class mediator; • DNA methylation-dependent heterochromatin assembly; • beta-catenin-TCF complex assembly; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization; • positive regulation of cell population proliferation; • GO:0045996 negative regulation of transcription, DNA-templated; • histone H3 deacetylation; • regulation of megakaryocyte differentiation; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • endoderm development; • ساعت زیستی; • hippocampus development; • neuron differentiation; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of oligodendrocyte differentiation; • regulation of endopeptidase activity; • regulation of amyloid-beta clearance; • negative regulation of intrinsic apoptotic signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3065
	433759
	ENSG00000116478
	ENSMUSG00000028800
	Q13547
	O09106
	NM_004964 XM_011541309، NM_004964
	NM_008228
	XP_011539611 NP_004955، XP_011539611
	NP_032254
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هیستون دِاَستیلاز ۱ (انگلیسی: Histone deacetylase 1) یک پروتئین است که در انسان توسط ژن «HDAC1» کُدگذاری می‌شود.^[۴]

این پروتئین نقش بسیار مهمی در تنظیم رونویسی ژن‌ها، پیشرفتِ چرخهٔ سلولی و وقایع تکاملی سلول دارد.

این پروتئین در دِاستیله کردنِ پروتئین پی۵۳ و تعدیل اثر آن بر روی رشد سلول و آپوپتوز نقش دارد.^[۵]

تعامل مولکولی[ویرایش]

این پروتئین با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

گیرنده آندروژن^[۶]
CDH1^[۷]
CTBP1^[۸]^[۹]^[۱۰]
GATA1^[۱۱]
HDAC2 ^[۱۲]^[۱۳]^[۱۴]^[۱۵]^[۱۶]^[۱۷]^[۱۸]^[۱۹]^[۲۰]^[۲۱]^[۲۲]^[۲۳]^[۲۴]
SMAD2^[۲۵]
پروتئین لوسمی پرومیلوسیتیک^[۲۶]^[۲۷]
SIN3A^[۱۲]^[۲۸]^[۱۳]^[۲۹]^[۲۲]^[۲۳]^[۳۰]^[۳۱]^[۳۲]^[۳۳]^[۳۴]^[۳۵]^[۳۶]^[۳۷]
فاکتور رونویسی Sp1^[۳۳]^[۳۸]^[۳۹]^[۴۰]
ZBTB16^[۴۱]^[۴۲]^[۴۳]

جستارهای وابسته[ویرایش]

هیستون داستیلاز

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028800 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Taunton J, Hassig CA, Schreiber SL (April 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260): 408–11. doi:10.1126/science.272.5260.408. PMID 8602529.
↑ "Entrez Gene: HDAC1 histone deacetylase 1".
↑ Gaughan L, Logan IR, Cook S, Neal DE, Robson CN (July 2002). "Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor". The Journal of Biological Chemistry. 277 (29): 25904–13. doi:10.1074/jbc.M203423200. PMID 11994312.
↑ Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Letters. 575 (1–3): 23–9. doi:10.1016/j.febslet.2004.07.089. PMID 15388328.
↑ Melhuish TA, Wotton D (December 2000). "The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF". The Journal of Biological Chemistry. 275 (50): 39762–6. doi:10.1074/jbc.C000416200. PMID 10995736.
↑ Zhang CL, McKinsey TA, Lu JR, Olson EN (January 2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor". The Journal of Biological Chemistry. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.
↑ Sundqvist A, Sollerbrant K, Svensson C (June 1998). "The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex". FEBS Letters. 429 (2): 183–8. doi:10.1016/s0014-5793(98)00588-2. PMID 9650586.
↑ Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, Naoe T, Saito H (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–84. doi:10.1038/sj.onc.1206902. PMID 14668799.
↑ ^۱۲٫۰ ^۱۲٫۱ Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (October 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.
↑ ^۱۳٫۰ ^۱۳٫۱ Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". The Journal of Biological Chemistry. 278 (43): 42560–8. doi:10.1074/jbc.M302955200. PMID 12920132.
↑ van der Vlag J, Otte AP (December 1999). "Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation". Nature Genetics. 23 (4): 474–8. doi:10.1038/70602. PMID 10581039.
↑ Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
↑ Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM (March 2002). "Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70". The Journal of Biological Chemistry. 277 (11): 9590–7. doi:10.1074/jbc.M107942200. PMID 11777905.
↑ Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D (February 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". The Journal of Biological Chemistry. 277 (8): 6656–66. doi:10.1074/jbc.M108055200. PMID 11739383.
↑ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
↑ Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4. PMID 11804585.
↑ Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal of Biological Chemistry. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
↑ Ashburner BP, Westerheide SD, Baldwin AS (October 2001). "The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression". Molecular and Cellular Biology. 21 (20): 7065–77. doi:10.1128/MCB.21.20.7065-7077.2001. PMC 99882. PMID 11564889.
↑ ^۲۲٫۰ ^۲۲٫۱ Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
↑ ^۲۳٫۰ ^۲۳٫۱ Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL (March 1998). "A role for histone deacetylase activity in HDAC1-mediated transcriptional repression". Proceedings of the National Academy of Sciences of the United States of America. 95 (7): 3519–24. doi:10.1073/pnas.95.7.3519. PMC 19868. PMID 9520398.
↑ Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/s0092-8674(00)80216-0. PMID 9150135.
↑ Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/s0092-8674(00)80712-6. PMID 10199400.
↑ Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S (June 2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Molecular Cell. 7 (6): 1233–43. doi:10.1016/s1097-2765(01)00257-x. PMID 11430826.
↑ Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS (April 2001). "The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases". Molecular and Cellular Biology. 21 (7): 2259–68. doi:10.1128/MCB.21.7.2259-2268.2001. PMC 86860. PMID 11259576.
↑ Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.
↑ Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
↑ You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
↑ Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (October 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.
↑ Zhang Y, Dufau ML (June 2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". The Journal of Steroid Biochemistry and Molecular Biology. 85 (2–5): 401–14. doi:10.1016/s0960-0760(03)00230-9. PMID 12943729.
↑ ^۳۳٫۰ ^۳۳٫۱ Zhang Y, Dufau ML (September 2002). "Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex". The Journal of Biological Chemistry. 277 (36): 33431–8. doi:10.1074/jbc.M204417200. PMID 12091390.
↑ Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/mcb.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
↑ Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA (February 2003). "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". The Biochemical Journal. 369 (Pt 3): 651–7. doi:10.1042/BJ20020854. PMC 1223118. PMID 12398767.
↑ Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Molecular Cell. 9 (3): 611–23. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
↑ Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes & Development. 14 (1): 45–54. PMC 316335. PMID 10640275.
↑ Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M (September 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.
↑ Singh J, Murata K, Itahana Y, Desprez PY (March 2002). "Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex". Oncogene. 21 (12): 1812–22. doi:10.1038/sj.onc.1205252. PMID 11896613.
↑ Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR (September 2002). "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". The Journal of Biological Chemistry. 277 (39): 35783–6. doi:10.1074/jbc.C200378200. PMID 12176973.
↑ David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
↑ Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736.
↑ Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry. 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306.

مشارکت‌کنندگان ویکی‌پدیا. «HDAC1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر[ویرایش]

Wolffe AP (April 1996). "Histone deacetylase: a regulator of transcription". Science. 272 (5260): 371–2. doi:10.1126/science.272.5260.371. PMID 8602525.
Ahringer J (August 2000). "NuRD and SIN3 histone deacetylase complexes in development". Trends in Genetics. 16 (8): 351–6. doi:10.1016/S0168-9525(00)02066-7. PMID 10904264.
Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators". Trends in Genetics. 19 (5): 286–93. doi:10.1016/S0168-9525(03)00073-8. PMID 12711221.
Zhang Y, Dufau ML (June 2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes" (PDF). The Journal of Steroid Biochemistry and Molecular Biology. 85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729.
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Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (May 1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell. 89 (3): 341–7. doi:10.1016/S0092-8674(00)80214-7. PMID 9150133.
Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (May 1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell. 89 (3): 349–56. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134.
Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
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پیون به بیرون[ویرایش]

HDAC1 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028800 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8602529-4] Taunton J, Hassig CA, Schreiber SL (April 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260): 408–11. doi:10.1126/science.272.5260.408. PMID 8602529.

[entrez-5] "Entrez Gene: HDAC1 histone deacetylase 1".

[pmid11994312-6] Gaughan L, Logan IR, Cook S, Neal DE, Robson CN (July 2002). "Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor". The Journal of Biological Chemistry. 277 (29): 25904–13. doi:10.1074/jbc.M203423200. PMID 11994312.

[pmid15388328-7] Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Letters. 575 (1–3): 23–9. doi:10.1016/j.febslet.2004.07.089. PMID 15388328.

[pmid10995736-8] Melhuish TA, Wotton D (December 2000). "The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF". The Journal of Biological Chemistry. 275 (50): 39762–6. doi:10.1074/jbc.C000416200. PMID 10995736.

[pmid11022042-9] Zhang CL, McKinsey TA, Lu JR, Olson EN (January 2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor". The Journal of Biological Chemistry. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.

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