حمل‌کننده ۱ روی

SLC30A1
معین‌کننده‌ها
نام‌های دیگر	SLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
شناسه‌های بیرونی	OMIM: 609521 MGI: 1345281 HomoloGene: 6681 GeneCards: SLC30A1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	191,645,359 bp
هستی‌شناسی ژن
عملکرد ملکولی	• calcium channel inhibitor activity; • cation transmembrane transporter activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • zinc ion transmembrane transporter activity;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • دستگاه گلژی; • پوشش هسته‌ای; • membrane; • لولچه عرضی; • پوسته یاخته; • شبکه آندوپلاسمی; • Schaffer collateral - CA1 synapse; • integral component of postsynaptic density membrane;
فرایند زیستی	• negative regulation of neurotransmitter secretion; • calcium ion import; • zinc ion transport; • cellular calcium ion homeostasis; • response to zinc ion; • cation transport; • in utero embryonic development; • ion transport; • negative regulation of calcium ion import; • detoxification of cadmium ion; • negative regulation of zinc ion transmembrane import; • zinc ion transmembrane transport; • cellular zinc ion homeostasis; • cadmium ion transmembrane transport; • regulation of sequestering of zinc ion; • transmembrane transport;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7779
	22782
	ENSG00000170385
	ENSMUSG00000037434
	Q9Y6M5
	Q60738
	NM_021194
	XM_006497158 NM_009579، XM_006497158
	NP_067017
	XP_006497221 NP_033605، XP_006497221
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین حمل‌کننده ۱ روی (انگلیسی: Zinc transporter 1) یک پروتئین است که در انسان توسط ژن «SLC30A1» کُدگذاری می‌شود.^[۴]^[۵]

پروتئین حمل‌کننده ۱ روی، نفوذ عنصر شیمیایی روی را از طریق «مجرای کلسیمی نوع L» تنظیم و تعدیل می‌کند. این پروتئین نه تنها ورود کاتیون روی، بلکه ورود کاتیون کلسیم را نیز کاهش می‌دهد، در نتیجه سلول‌ها را از تأثیرات نفوذ بیش از حد این کاتیون‌ها محافظت می‌کند.^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000037434 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC 398127. PMID 7882967.
↑ Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.
↑ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.

برای مطالعهٔ بیشتر[ویرایش]

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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000037434 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7882967-4] Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC 398127. PMID 7882967.

[pmid15154973-5] Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.

[pmid15451416-6] Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.

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