انتقال‌دهنده ۲ اسید آمینه خنثی جفت‌شونده با سدیم

SLC38A2
معین‌کننده‌ها
نام‌های دیگر	SLC38A2, ATA2, PRO1068, SAT2, SNAT2, solute carrier family 38 member 2
شناسه‌های بیرونی	OMIM: 605180 MGI: 1915010 HomoloGene: 23132 GeneCards: SLC38A2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۵ (موش)
پایان	96,597,611 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • symporter activity; • amino acid transmembrane transporter activity; • L-glutamine transmembrane transporter activity;
ترکیبات سلولی	• integral component of membrane; • membrane; • پوسته یاخته; • integral component of plasma membrane; • آسه; • neuronal cell body; • دندریت; • brush border; • سارکولما;
فرایند زیستی	• sodium ion transport; • female pregnancy; • cellular response to amino acid starvation; • glutamate secretion; • cellular response to mechanical stimulus; • glycine betaine transport; • cerebral cortex development; • amino acid transport; • alanine transport; • ion transport; • amino acid transmembrane transport; • glutamine transport;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	54407
	67760
	ENSG00000134294
	ENSMUSG00000022462
	Q96QD8
	Q8CFE6
	NM_018976، XM_047429019، XM_047429020 NM_001307936، NM_018976، XM_047429019، XM_047429020
	NM_001355633، XM_036159554 NM_175121، NM_001355633، XM_036159554
	NP_061849 NP_001294865، NP_061849; NP_061849.2
	NP_001342562، XP_036015447 NP_780330، NP_001342562، XP_036015447
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

انتقال‌دهنده ۲ اسید آمینه خنثی جفت‌شونده با سدیم (انگلیسی: Sodium-coupled neutral amino acid transporter 2) یک پروتئین است که در انسان توسط ژن «SLC38A2» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022462 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem. 275 (22): 16473–7. doi:10.1074/jbc.C000205200. PMID 10747860.
↑ Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J. 92 (7): 2621–32. doi:10.1529/biophysj.106.100776. PMC 1864845. PMID 17237199.
↑ "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

مشارکت‌کنندگان ویکی‌پدیا. «Sodium-coupled neutral amino acid transporter 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۱ آوریل ۲۰۲۰.

برای مطالعهٔ بیشتر[ویرایش]

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Hatanaka T, Huang W, Wang H, et al. (2000). "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.". Biochim. Biophys. Acta. 1467 (1): 1–6. doi:10.1016/S0005-2736(00)00252-2. PMID 10930503.
Freeman TL, Thiele GM, Tuma DJ, et al. (2002). "ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane". Arch. Biochem. Biophys. 400 (2): 215–22. doi:10.1016/S0003-9861(02)00006-1. PMID 12054432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Palii SS, Chen H, Kilberg MS (2004). "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element". J. Biol. Chem. 279 (5): 3463–71. doi:10.1074/jbc.M310483200. PMID 14623874.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Franchi-Gazzola R, Gaccioli F, Bevilacqua E, et al. (2005). "The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity". Biochim. Biophys. Acta. 1667 (2): 157–66. doi:10.1016/j.bbamem.2004.09.012. PMID 15581851.
Bevilacqua E, Bussolati O, Dall'Asta V, et al. (2005). "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress". FEBS Lett. 579 (16): 3376–80. doi:10.1016/j.febslet.2005.05.002. PMID 15922329.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Novak D, Quiggle F, Haafiz A (2006). "Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells". Biochimie. 88 (1): 39–44. doi:10.1016/j.biochi.2005.07.002. PMID 16125834.
Palii SS, Thiaville MM, Pan YX, et al. (2006). "Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene". Biochem. J. 395 (3): 517–27. doi:10.1042/BJ20051867. PMC 1462688. PMID 16445384.
Melone M, Varoqui H, Erickson JD, Conti F (2006). "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex". Neuroscience. 140 (1): 281–92. doi:10.1016/j.neuroscience.2006.02.042. PMID 16616430.
Gaccioli F, Huang CC, Wang C, et al. (2006). "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation". J. Biol. Chem. 281 (26): 17929–40. doi:10.1074/jbc.M600341200. PMID 16621798.
Jones HN, Ashworth CJ, Page KR, McArdle HJ (2006). "Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)". Am. J. Physiol. Endocrinol. Metab. 291 (3): E596–603. doi:10.1152/ajpendo.00359.2005. PMID 16621896.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022462 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10747860-4] Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem. 275 (22): 16473–7. doi:10.1074/jbc.C000205200. PMID 10747860.

[pmid17237199-5] Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J. 92 (7): 2621–32. doi:10.1529/biophysj.106.100776. PMC 1864845. PMID 17237199.

[entrez-6] "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

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