IRF9

IRF9
معین‌کننده‌ها
نام‌های دیگر	IRF9, IRF-9, ISGF3, ISGF3G, p48, interferon regulatory factor 9
شناسه‌های بیرونی	OMIM: 147574 MGI: 107587 HomoloGene: 4436 GeneCards: IRF9
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	55,847,487 bp
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
ترکیبات سلولی	• هسته یاخته; • نوکلئوپلاسم; • سیتوپلاسم; • سیتوزول;
فرایند زیستی	• cell surface receptor signaling pathway; • GO:0009373 regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • defense response to virus; • type I interferon signaling pathway; • transcription, DNA-templated; • interferon-gamma-mediated signaling pathway; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • immune system process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10379
	16391
	ENSG00000213928; ENSG00000285048
	ENSMUSG00000002325
	Q00978
	Q61179
	NM_001385400، NM_001385401، NM_001385402 NM_006084، NM_001385400، NM_001385401، NM_001385402
	NM_001159418، NM_008394 NM_001159417، NM_001159418، NM_008394
	NP_006075
	NP_001152890، NP_032420 NP_001152889، NP_001152890، NP_032420
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور ۹ تنظیم کننده اینترفرون پروتئینی است که در انسان توسط ژن IRF9 که قبلاً ISGF3G نامیده می‌شد کدگذاری می‌شود.^[۴]^[۵]^[۶]

فعل و انفعالات[ویرایش]

مشخص شده‌است که IRF9 با STAT2^[۷]^[۸] و STAT1 تعامل پروتئین-پروتئین دارد.^[۷]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000002325 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr, Levy DE (Aug 1992). "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins". Mol Cell Biol. 12 (8): 3315–24. doi:10.1128/MCB.12.8.3315. PMC 364572. PMID 1630447.
↑ McCusker D, Wilson M, Trowsdale J (Jun 1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics. 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920.
↑ "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa".
↑ ^۷٫۰ ^۷٫۱ Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. UNITED STATES. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. ISSN 0270-7306. PMC 231699. PMID 8943351.
↑ Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. UNITED STATES. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679.

جهت مطالعه[ویرایش]

Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". Intervirology. 42 (5–6): 325–30. doi:10.1159/000053968. PMID 10702714. S2CID 22135982.
Reich NC (2002). "Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation". J. Interferon Cytokine Res. 22 (1): 103–9. doi:10.1089/107999002753452719. PMID 11846981.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
David M, Romero G, Zhang ZY, et al. (1993). "In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase". J. Biol. Chem. 268 (9): 6593–9. doi:10.1016/S0021-9258(18)53292-0. PMID 8454630.
Horvath CM, Stark GR, Kerr IM, Darnell JE (1997). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. PMC 231699. PMID 8943351.
Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679.
Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
Lau JF, Parisien JP, Horvath CM (2000). "Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7278–83. Bibcode:2000PNAS...97.7278L. doi:10.1073/pnas.97.13.7278. PMC 16536. PMID 10860992.
Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. doi:10.1128/MCB.22.11.3942-3957.2002. PMC 133824. PMID 11997525.
Chawla-Sarkar M, Leaman DW, Jacobs BS, et al. (2002). "Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1)". J. Interferon Cytokine Res. 22 (5): 603–13. doi:10.1089/10799900252982089. PMID 12060499.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lau JF, Nusinzon I, Burakov D, et al. (2003). "Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription". Mol. Cell. Biol. 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. PMC 151539. PMID 12509459.
Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Thompson HG, Harris JW, Lin L, Brody JP (2004). "Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells". Exp. Cell Res. 295 (2): 448–59. doi:10.1016/j.yexcr.2004.01.019. PMID 15093743.
Sakamoto S, Potla R, Larner AC (2004). "Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes". J. Biol. Chem. 279 (39): 40362–7. doi:10.1074/jbc.M406400200. PMID 15194680.

پیوند به بیرون[ویرایش]

ISGF3G protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژن انسانی IRF9 در مرورگر ژنومی UCSC.
جزئیات ژن انسانی IRF9 در مرورگر ژنومی UCSC.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000002325 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_1630447-4] Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr, Levy DE (Aug 1992). "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins". Mol Cell Biol. 12 (8): 3315–24. doi:10.1128/MCB.12.8.3315. PMC 364572. PMID 1630447.

[pmid_10199920-5] McCusker D, Wilson M, Trowsdale J (Jun 1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics. 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920.

[entrez-6] "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa".

[pmid_8943351-7] ۷٫۰ ^۷٫۱ Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. UNITED STATES. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. ISSN 0270-7306. PMC 231699. PMID 8943351.

[pmid_9242679-8] Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. UNITED STATES. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679.

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