GABRG2

GABRG2
معین‌کننده‌ها
نام‌های دیگر	GABRG2, CAE2, ECA2, GEFSP3, gamma-aminobutyric acid type A receptor gamma2 subunit, EIEE74, FEB8
شناسه‌های بیرونی	OMIM: 137164 MGI: 95623 HomoloGene: 22443 GeneCards: GABRG2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	41,891,684 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • benzodiazepine receptor activity; • extracellular ligand-gated ion channel activity; • chloride channel activity; • GABA-A receptor activity; • ion channel activity; • transmembrane signaling receptor activity; • inhibitory extracellular ligand-gated ion channel activity; • GABA-gated chloride ion channel activity; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
ترکیبات سلولی	• integral component of membrane; • postsynaptic membrane; • membrane; • سیناپس; • dendrite membrane; • chloride channel complex; • آسه; • پیوند میان‌یاخته‌ای; • integral component of plasma membrane; • پوسته یاخته; • دندریت; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • cell projection; • GABA-A receptor complex; • neuron projection; • postsynapse; • GABA-ergic synapse;
فرایند زیستی	• gamma-aminobutyric acid signaling pathway; • synaptic transmission, GABAergic; • ion transport; • post-embryonic development; • adult behavior; • chloride transport; • cellular response to histamine; • chemical synaptic transmission; • chloride transmembrane transport; • ion transmembrane transport; • GO:0072468 ورارسانی پیام; • regulation of membrane potential; • nervous system process; • regulation of postsynaptic membrane potential; • inhibitory synapse assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2566
	14406
	ENSG00000113327
	ENSMUSG00000020436
	P18507
	P22723
	NM_000816، NM_198903 NM_198904، NM_000816، NM_198903
	NM_177408، NM_001362655، NM_001362656، XM_030245561، XM_036156333 NM_008073، NM_177408، NM_001362655، NM_001362656، XM_030245561، XM_036156333
	NP_944493، NP_944494، NP_001362268، NP_001362269، NP_001362270، NP_001362271، NP_001362272، NP_001362273، NP_001362274، NP_001362275، NP_001362276، NP_001362277، NP_001362278، NP_001362279 NP_000807، NP_944493، NP_944494، NP_001362268، NP_001362269، NP_001362270، NP_001362271، NP_001362272، NP_001362273، NP_001362274، NP_001362275، NP_001362276، NP_001362277، NP_001362278، NP_001362279
	NP_803127، NP_001349584، NP_001349585، XP_030101421، XP_036012226 NP_032099، NP_803127، NP_001349584، NP_001349585، XP_030101421، XP_036012226
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

زیرواحد گاما-۲ گیرندهٔ گاما-آمینوبوتیریک اسید (انگلیسی: Gamma-aminobutyric acid receptor subunit gamma-2) یک پروتئین است که در انسان توسط ژن «GABRG2» کُدگذاری می‌شود.

این پروتئین با مولکول‌های GABARAP^[۴]^[۵]^[۶] و گیرنده دی۵ دوپامین^[۷] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته[ویرایش]

گیرنده گابا A

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020436 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.
↑ Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.
↑ Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.
↑ Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 (6767): 274–280. Bibcode:2000Natur.403..274L. doi:10.1038/35002014. PMID 10659839. S2CID 4415918.

مشارکت‌کنندگان ویکی‌پدیا. «Gamma-aminobutyric acid receptor subunit gamma-2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر[ویرایش]

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Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.
Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proceedings of the National Academy of Sciences of the United States of America. 96 (17): 9891–9896. Bibcode:1999PNAS...96.9891B. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
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Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020436 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11948245-4] Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.

[pmid11779480-5] Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.

[pmid9892355-6] Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.

[pmid10659839-7] Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 (6767): 274–280. Bibcode:2000Natur.403..274L. doi:10.1038/35002014. PMID 10659839. S2CID 4415918.

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