BAD

BAD
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1G5J
معین‌کننده‌ها
نام‌های دیگر	BAD, BBC2, BCL2L8, BCL2 associated agonist of cell death
شناسه‌های بیرونی	OMIM: 603167 MGI: 1096330 HomoloGene: 3189 GeneCards: BAD
موقعیت ژن (موش) کروموزوم کروموزوم ۱۹ (موش) نوار 19|19 A شروع 6,919,229 bp پایان 6,929,267 bp
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • 14-3-3 protein binding • protein phosphatase binding • GO:0001948، GO:0016582 پیوند پروتئینی • protein heterodimerization activity • cysteine-type endopeptidase activator activity involved in apoptotic process • phospholipid binding • protein kinase binding • lipid binding • protein phosphatase 2B binding • protein kinase B binding ترکیبات سلولی • سیتوپلاسم • سیتوزول • membrane • mitochondrial outer membrane • میتوکندری فرایند زیستی • positive regulation of T cell differentiation • cellular response to hypoxia • regulation of apoptotic process • response to amino acid • response to estradiol • response to hypoxia • positive regulation of type B pancreatic cell development • GO:1904578 response to organic cyclic compound • extrinsic apoptotic signaling pathway • positive regulation of autophagy • glucose homeostasis • cytokine-mediated signaling pathway • response to testosterone • positive regulation of epithelial cell proliferation • positive regulation of B cell differentiation • response to progesterone • positive regulation of apoptotic process by virus • pore complex assembly • cellular response to nicotine • response to glucocorticoid • positive regulation of neuron death • response to glucose • regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to organic substance • response to calcium ion • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • ATP metabolic process • cellular response to mechanical stimulus • activation of cysteine-type endopeptidase activity • regulation of mitochondrial membrane permeability • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway • positive regulation of glucokinase activity • اسپرماتوژنز • glucose catabolic process • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of proteolysis • cerebral cortex development • extrinsic apoptotic signaling pathway in absence of ligand • cellular response to lipid • positive regulation of release of cytochrome c from mitochondria • response to hormone • positive regulation of mitochondrial membrane potential • positive regulation of insulin secretion involved in cellular response to glucose stimulus • suppression by virus of host apoptotic process • response to ethanol • ADP metabolic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • تکثیر سلولی • type B pancreatic cell proliferation • cellular response to chromate • extrinsic apoptotic signaling pathway via death domain receptors • response to hydrogen peroxide • response to oleic acid • release of cytochrome c from mitochondria • positive regulation of insulin secretion • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته • intrinsic apoptotic signaling pathway • apoptotic signaling pathway • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • positive regulation of apoptotic process • positive regulation of granulosa cell apoptotic process منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	572	12015
آنسامبل	ENSG00000002330	ENSMUSG00000024959
یونی‌پروت	Q92934	Q61337
RefSeq (mRNA)	NM_004322 NM_032989، NM_004322	NM_001285453 NM_007522، NM_001285453
RefSeq (پروتئین)	NP_116784 NP_004313، NP_116784	NP_031548 NP_001272382، NP_031548
موقعیت (UCSC)	ن/م	Chr : 6.92 – 6.93 Mb
جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

Pro-apoptotic Bcl-2 protein, BAD
کمپلکس ترکیبی مولکول bcl-xl با پپتیدی از پروتئینِ BAD
شناسه‌ها
نماد	Bcl-2_BAD
پی‌فم	PF10514
اینترپرو	IPR018868
ساختارهای پروتئینی در دسترس: پی‌فم   structures / ECOD   پی‌دی‌بی RCSB PDB; PDBe; PDBj پی‌دی‌بی‌سام structure summary

آگونیست مرگ سلول مرتبط با لنفوم ۲ لنفوسیت‌های بی (انگلیسی: Bcl-2-associated death promoter) یک پروتئین است که در انسان توسط ژن «BAD» کُدگذاری می‌شود.

این پروتئین القاکنندهٔ آپوپتوز سلولی و عضوی از خانوادهٔ BH3 (از زیرگروه‌های خانواده Bcl-2) است با این تفاوت که بر خلاف بیشتر اعضای این خانواده، فاقد دومِـین کربوکسیل تراغشایی در لایهٔ خارجی میتوکندری و هسته سلول است.

منابع

• مشارکت‌کنندگان ویکی‌پدیا. «Bcl-2-associated death promoter». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اکتبر ۲۰۲۰.

برای مطالعهٔ بیشتر

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پیوند به بیرون

• bcl-Associated Death Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
• مکان ژنوم BAD انسانی و صفحهٔ جزئیات ژنی BAD در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.