AP2A2

AP2A2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
معین‌کننده‌ها
نام‌های دیگر	AP2A2, ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2
شناسه‌های بیرونی	OMIM: 607242 MGI: 101920 HomoloGene: 5335 GeneCards: AP2A2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	141,212,924 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• clathrin adaptor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein kinase binding; • lipid binding; • protein domain specific binding; • disordered domain specific binding; • molecular function;
ترکیبات سلولی	• endocytic vesicle membrane; • سیتوزول; • clathrin-coated endocytic vesicle membrane; • membrane; • پوسته یاخته; • endolysosome membrane; • membrane coat; • clathrin-coated pit; • AP-2 adaptor complex; • clathrin adaptor complex; • secretory granule membrane; • GO:0016023 cytoplasmic vesicle; • ficolin-1-rich granule membrane; • clathrin-coated endocytic vesicle;
فرایند زیستی	• اندوسیتوز; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • ephrin receptor signaling pathway; • GO:0019049، GO:0030683 mitigation of host defenses by virus; • clathrin-dependent endocytosis; • protein transport; • intracellular protein transport; • vesicle-mediated transport; • microtubule-based movement; • Wnt signaling pathway, planar cell polarity pathway; • neutrophil degranulation; • membrane organization; • low-density lipoprotein particle receptor catabolic process; • low-density lipoprotein particle clearance; • GO:0015915 transport;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	161
	11772
	ENSG00000281385; ENSG00000280759; ENSG00000183020
	ENSMUSG00000002957
	O94973
	P17427
	NM_012305، XM_011519929، XM_011519930، NR_144509، NR_144510، XM_047426479، XM_047426480، XM_047426481، XM_047426482، XM_047426484، XM_047426485 NM_001242837، NM_012305، XM_011519929، XM_011519930، NR_144509، NR_144510، XM_047426479، XM_047426480، XM_047426481، XM_047426482، XM_047426484، XM_047426485
	NM_001357068 NM_007459، NM_001357068
	NP_036437، XP_011518231، XP_011518232 NP_001229766، NP_036437، XP_011518231، XP_011518232
	NP_001343997 NP_031485، NP_001343997
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

کمپلکس AP-2 زیرواحد آلفا-۲ (انگلیسی: AP-2 complex subunit alpha-2) یک پروتئین است که در انسان توسط ژن «AP2A2» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

این پروتئین با SHC1^[۷] و EPN1^[۸] تعامل پروتئین-پروتئین دارد.

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000002957 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
↑ Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.
↑ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".
↑ Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.
↑ Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.

مشارکت‌کنندگان ویکی‌پدیا. «AP2A2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۰ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

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David C, McPherson PS, Mundigl O, de Camilli P (Jan 1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 331–5. doi:10.1073/pnas.93.1.331. PMC 40232. PMID 8552632.
Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.
Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (May 1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein". The Journal of Biological Chemistry. 271 (20): 12111–6. doi:10.1074/jbc.271.20.12111. PMID 8662627.
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Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology. 73 (2): 1350–61. PMC 103959. PMID 9882340.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Traub LM, Downs MA, Westrich JL, Fremont DH (Aug 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 8907–12. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.
Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
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