گیرنده مرگ ۴

TNFRSF10A
معین‌کننده‌ها
نام‌های دیگر	TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10a, TNF receptor superfamily member 10a
شناسه‌های بیرونی	OMIM: 603611 MGI: 1341090 HomoloGene: 129806 GeneCards: TNFRSF10A
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	70,021,860 bp
هستی‌شناسی ژن
عملکرد ملکولی	• TRAIL binding; • transcription factor binding; • protease binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • tumor necrosis factor-activated receptor activity; • death receptor activity; • signaling receptor activity;
ترکیبات سلولی	• membrane; • پوسته یاخته; • integral component of plasma membrane; • cell surface; • intracellular anatomical structure; • integral component of membrane;
فرایند زیستی	• activation of NF-kappaB-inducing kinase activity; • TRAIL-activated apoptotic signaling pathway; • multicellular organism development; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • cellular response to mechanical stimulus; • regulation of cell population proliferation; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • regulation of extrinsic apoptotic signaling pathway via death domain receptors; • inflammatory response; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • extrinsic apoptotic signaling pathway via death domain receptors; • GO:0072468 ورارسانی پیام; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • extrinsic apoptotic signaling pathway; • tumor necrosis factor-mediated signaling pathway; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • leukocyte migration; • regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of apoptotic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8797
	21933
	ENSG00000104689
	ENSMUSG00000022074
	O00220
	Q9QZM4
	NM_003844
	XM_036158575 NM_020275، XM_036158575
	NP_003835
	XP_036014468 NP_064671، XP_036014468
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده مرگ ۴ (انگلیسی: Death receptor 4) که با نام‌های DR4، CD261 و گیرندهٔ تریل ۱ نیز شناخته می‌شود، یک گیرندهٔ سطح سلول از ابرخانواده گیرنده‌های فاکتور نکروز تومور است که به پروتئین تریل متصل شده و در خزان یاخته‌ای نقش دارد.^[۴]^[۵]

این گیرنده با DAP3، تعامل پروتئین-پروتئین دارد.^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022074 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMC 1170170. PMID 9311998.
↑ Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980.
↑ Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. United States. 2 (6): 493–500. doi:10.1038/88684. ISSN 1529-2908. PMID 11376335. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysummary= و |laysource= (help)

مشارکت‌کنندگان ویکی‌پدیا. «Death receptor 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359–72. doi:10.1038/sj.cr.7290236. PMID 15538968.
Fleury S, Thibodeau J, Croteau G, et al. (1995). "HLA-DR polymorphism affects the interaction with CD4". J. Exp. Med. 182 (3): 733–41. doi:10.1084/jem.182.3.733. PMC 2192178. PMID 7650480.
MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.
Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL". FEBS Lett. 416 (3): 329–34. doi:10.1016/S0014-5793(97)01231-3. PMID 9373179.
Marsters SA, Sheridan JP, Pitti RM, et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr. Biol. 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.
Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity. 7 (6): 821–30. doi:10.1016/S1074-7613(00)80400-8. PMID 9430227.
Schneider P, Thome M, Burns K, et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB". Immunity. 7 (6): 831–6. doi:10.1016/S1074-7613(00)80401-X. PMID 9430228.
Diab BY, Lambert NC, L'Faqihi FE, et al. (1999). "Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis". Immunogenetics. 49 (1): 36–44. doi:10.1007/s002510050461. PMID 9811967.
Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–32. doi:10.1074/jbc.274.29.20127. PMID 10400625.
Hymowitz SG, Christinger HW, Fuh G, et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5". Mol. Cell. 4 (4): 563–71. doi:10.1016/S1097-2765(00)80207-5. PMID 10549288.
Gibson SB, Oyer R, Spalding AC, et al. (2000). "Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL". Mol. Cell. Biol. 20 (1): 205–12. doi:10.1128/MCB.20.1.205-212.2000. PMC 85076. PMID 10594023.
Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. 2 (6): 493–500. doi:10.1038/88684. PMID 11376335.
Trauzold A, Wermann H, Arlt A, et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells". Oncogene. 20 (31): 4258–69. doi:10.1038/sj.onc.1204559. PMID 11464292.
Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. Neurosci. 22 (4): RC209. PMID 11844843.
Koyama S, Koike N, Adachi S (2002). "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor". J. Cancer Res. Clin. Oncol. 128 (2): 73–9. doi:10.1007/s004320100292. PMID 11862476.
Guan B, Yue P, Lotan R, Sun SY (2002). "Evidence that the human death receptor 4 is regulated by activator protein 1". Oncogene. 21 (20): 3121–9. doi:10.1038/sj.onc.1205430. PMID 12082627.
Söderström TS, Poukkula M, Holmström TH, et al. (2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8". J. Immunol. 169 (6): 2851–60. doi:10.4049/jimmunol.169.6.2851. PMID 12218097.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022074 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9311998-4] Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMC 1170170. PMID 9311998.

[pmid9082980-5] Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980.

[pmid11376335-6] Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. United States. 2 (6): 493–500. doi:10.1038/88684. ISSN 1529-2908. PMID 11376335. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysummary= و |laysource= (help)

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