ناقل ۱ تمرکزدهنده نوکلئوزید

از ویکی‌پدیا، دانشنامهٔ آزاد
SLC28A1
معین‌کننده‌ها
نام‌های دیگرSLC28A1, CNT1, HCNT1, Concentrative nucleoside transporter 1, solute carrier family 28 member 1, URCTU
شناسه‌های بیرونیOMIM: 606207 MGI: 3605073 HomoloGene: 37902 GeneCards: SLC28A1
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

9154

434203

آنسامبل

ENSG00000156222

ENSMUSG00000025726

یونی‌پروت

O00337

E9PXX9

RefSeq (mRNA)

NM_001287761، NM_001287762، NM_004213، NM_201651، XM_011522203، XM_011522204، XM_011522205، XM_011522206، XM_011522208، XM_011522209، XM_011522210، XM_011522212، XM_011522214، XM_011522215، XM_011522216، XM_011522217، XM_011522218، NM_001321721، NM_001321722، XM_017022723، XM_047433320، XM_047433322 XR_931945، NM_001287761، NM_001287762، NM_004213، NM_201651، XM_011522203، XM_011522204، XM_011522205، XM_011522206، XM_011522208، XM_011522209، XM_011522210، XM_011522212، XM_011522214، XM_011522215، XM_011522216، XM_011522217، XM_011522218، NM_001321721، NM_001321722، XM_017022723، XM_047433320، XM_047433322

XM_006540976، XM_006540977، XM_006540978، XM_006540979، XR_391350، XM_011250875 NM_001004184، XM_006540976، XM_006540977، XM_006540978، XM_006540979، XR_391350، XM_011250875

RefSeq (پروتئین)

NP_001274691، NP_001308650، NP_001308651، NP_004204، NP_964014، XP_011520505، XP_011520506، XP_011520507، XP_011520508، XP_011520510، XP_011520511، XP_011520512، XP_011520513، XP_011520514، XP_011520516، XP_011520517، XP_011520518، XP_011520519، XP_011520520، XP_016878212، XP_024305867، XP_024305868، XP_024305869، XP_024305870 NP_001274690، NP_001274691، NP_001308650، NP_001308651، NP_004204، NP_964014، XP_011520505، XP_011520506، XP_011520507، XP_011520508، XP_011520510، XP_011520511، XP_011520512، XP_011520513، XP_011520514، XP_011520516، XP_011520517، XP_011520518، XP_011520519، XP_011520520، XP_016878212، XP_024305867، XP_024305868، XP_024305869، XP_024305870

XP_006541039، XP_006541040، XP_006541041، XP_006541042، XP_011249177 NP_001004184، XP_006541039، XP_006541040، XP_006541041، XP_006541042، XP_011249177

موقعیت (UCSC)ن/مChr : 80.76 – 80.82 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

ناقل ۱ تمرکزدهنده نوکلئوزید (انگلیسی: Concentrative nucleoside transporter 1) یک پروتئین است که در انسان توسط ژن «SLC28A1» کُدگذاری می‌شود.[۴][۵]

جستارهای وابسته[ویرایش]

منابع[ویرایش]

  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000025726 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD (Apr 1997). "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)". Am J Physiol. 272 (2 Pt 1): C707–14. PMID 9124315.
  5. ↑ "Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1".

برای مطالعهٔ بیشتر[ویرایش]

  • Ritzel MW, Ng AM, Yao SY, et al. (2001). "Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)". Mol. Membr. Biol. 18 (1): 65–72. doi:10.1080/09687680118530. PMID 11396613.
  • Ritzel MW, Yao SY, Ng AM, et al. (1999). "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine". Mol. Membr. Biol. 15 (4): 203–11. doi:10.3109/09687689709044322. PMID 10087507.
  • Loewen SK, Ng AM, Yao SY, et al. (1999). "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2". J. Biol. Chem. 274 (35): 24475–84. doi:10.1074/jbc.274.35.24475. PMID 10455109.
  • Mata JF, García-Manteiga JM, Lostao MP, et al. (2001). "Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug". Mol. Pharmacol. 59 (6): 1542–8. PMID 11353816.
  • Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies". J. Biol. Chem. 277 (40): 37711–7. doi:10.1074/jbc.M204986200. PMID 12097333.
  • Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627.
  • Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • García-Manteiga J, Molina-Arcas M, Casado FJ, et al. (2004). "Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity". Clin. Cancer Res. 9 (13): 5000–8. PMID 14581375.
  • Loewen SK, Yao SY, Slugoski MD, et al. (2004). "Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes". Mol. Membr. Biol. 21 (1): 1–10. doi:10.1080/0968768031000140836. PMID 14668133.
  • Gray JH, Mangravite LM, Owen RP, et al. (2004). "Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations". Mol. Pharmacol. 65 (3): 512–9. doi:10.1124/mol.65.3.512. PMID 14978229.
  • Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors". Int. J. Cancer. 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342.
  • Lai Y, Lee EW, Ton CC, et al. (2005). "Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively". Am. J. Physiol., Cell Physiol. 288 (1): C39–45. doi:10.1152/ajpcell.00192.2004. PMID 15456697.
  • Fernández-Veledo S, Jover R, Casado FJ, et al. (2007). "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells". Biochem. Biophys. Res. Commun. 353 (2): 381–8. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757.
  • Slugoski MD, Loewen SK, Ng AM, et al. (2007). "Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling". Biochemistry. 46 (6): 1684–93. doi:10.1021/bi061692s. PMID 17279631.
  • Smith KM, Slugoski MD, Cass CE, et al. (2007). "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3". Mol. Membr. Biol. 24 (1): 53–64. doi:10.1080/09687860600942534. PMID 17453413.
  • Guallar JP, Cano-Soldado P, Aymerich I, et al. (2007). "Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients". Antivir. Ther. (Lond.). 12 (6): 853–63. PMID 17926640.
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