درلین-۲

DERL2
معین‌کننده‌ها
نام‌های دیگر	DERL2, F-LAN-1, F-LANa, FLANa, CGI-101, DERtrin-2, derlin 2, derlin-2
شناسه‌های بیرونی	OMIM: 610304 MGI: 2151483 HomoloGene: 9356 GeneCards: DERL2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	70,910,667 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • serine-type endopeptidase activity;
ترکیبات سلولی	• integral component of membrane; • integral component of endoplasmic reticulum membrane; • late endosome; • early endosome; • endoplasmic reticulum membrane; • شبکه آندوپلاسمی; • membrane; • endoplasmic reticulum quality control compartment; • signal recognition particle receptor complex; • ذره شناسایی سیگنال;
فرایند زیستی	• endoplasmic reticulum unfolded protein response; • positive regulation of cell growth; • retrograde protein transport, ER to cytosol; • response to unfolded protein; • negative regulation of retrograde protein transport, ER to cytosol; • positive regulation of cell population proliferation; • ubiquitin-dependent ERAD pathway; • suckling behavior; • endoplasmic reticulum mannose trimming; • پروتئین‌کافت;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	51009
	116891
	ENSG00000072849
	ENSMUSG00000018442
	Q9GZP9
	Q8BNI4
	NM_001304779، NM_016041، NR_130905، NR_130906، XR_001752523، XR_002958015، XR_002958016 NM_001304777، NM_001304779، NM_016041، NR_130905، NR_130906، XR_001752523، XR_002958015، XR_002958016
	NM_001291147، NM_001291148، NM_033562، XM_017314227 NM_001291146، NM_001291147، NM_001291148، NM_033562، XM_017314227
	NP_001291708، NP_057125 NP_001291706، NP_001291708، NP_057125
	NP_001278076، NP_001278077، NP_291040، XP_017169716 NP_001278075، NP_001278076، NP_001278077، NP_291040، XP_017169716
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

درلین-۲ پروتئینی است که در انسان توسط ژن DERL2 کدگذاری می‌شود.^[۴]^[۵]^[۶]

همچنین ببینید[ویرایش]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000018442 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
↑ Ying H, Yu Y, Xu Y (Aug 2001). "Cloning and characterization of F-LANa, upregulated in human liver cancer". Biochem Biophys Res Commun. 286 (2): 394–400. doi:10.1006/bbrc.2001.5390. PMID 11500051.
↑ "Entrez Gene: DERL2 Der1-like domain family, member 2".

جهت مطالعه[ویرایش]

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lilley BN, Ploegh HL (2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lilley BN, Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296–301. doi:10.1073/pnas.0505014102. PMC 1242303. PMID 16186509.
Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
Rhee S, Grinnell F (2006). "P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts". J. Cell Biol. 172 (3): 423–32. doi:10.1083/jcb.200505175. PMC 2063651. PMID 16449192.
Maas C, Tagnaouti N, Loebrich S, et al. (2006). "Neuronal cotransport of glycine receptor and the scaffold protein gephyrin". J. Cell Biol. 172 (3): 441–51. doi:10.1083/jcb.200506066. PMC 2063653. PMID 16449194.
Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL (2006). "Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection". J. Virol. 80 (17): 8739–44. doi:10.1128/JVI.00791-06. PMC 1563856. PMID 16912321.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000018442 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_10810093-4] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[pmid_11500051-5] Ying H, Yu Y, Xu Y (Aug 2001). "Cloning and characterization of F-LANa, upregulated in human liver cancer". Biochem Biophys Res Commun. 286 (2): 394–400. doi:10.1006/bbrc.2001.5390. PMID 11500051.

[entrez-6] "Entrez Gene: DERL2 Der1-like domain family, member 2".

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