الگو:PBB/1026

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Constructed from 1AXC
ساختارهای موجود بانک داده پروتئین Ortholog search: PDBe, RCSB فهرست کدهای شناسه PDB 1AXC, 2ZVV, 2ZVW
شاخص‌ها
نماد ژن	CDKN1A; CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1
شناسه‌های بیرونی	OMIM: 116899 MGI: 104556 HomoloGene: 333 ChEMBL: 5021 GeneCards: CDKN1A Gene
هستی‌شناسی ژن Molecular function • cyclin-dependent protein kinase inhibitor activity • protein binding • cyclin-dependent protein kinase activating kinase activity • cyclin binding • metal ion binding Cellular component • cyclin-dependent protein kinase holoenzyme complex • nucleus • nucleoplasm • cytosol • PCNA-p21 complex Biological process • cell cycle checkpoint • regulation of cyclin-dependent protein kinase activity • G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • G2/M transition of mitotic cell cycle • mitotic cell cycle • response to DNA damage stimulus • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cell cycle arrest • Ras protein signal transduction • negative regulation of cell proliferation • response to UV • response to toxin • response to organic nitrogen • negative regulation of gene expression • response to organic cyclic compound • negative regulation of cell growth • positive regulation of B cell proliferation • organ regeneration • cellular response to extracellular stimulus • regulation of protein import into nucleus, translocation • negative regulation of phosphorylation • response to drug • negative regulation of apoptotic process • negative regulation of cyclin-dependent protein kinase activity • positive regulation of anti-apoptosis • response to arsenic-containing substance • positive regulation of fibroblast proliferation • response to corticosterone stimulus • response to hyperoxia • cellular response to ionizing radiation • mitotic cell cycle arrest • cellular senescence • replicative senescence • stress-induced premature senescence • regulation of DNA biosynthetic process • positive regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
الگوی بیان RNA
دادهای بیان مرجع بیشتر
اورتولوگ
گونه‌ها	انسان	موش
آنتره	1026	12575
آنسامبل	ENSG00000124762	ENSMUSG00000023067
UniProt	P38936	P39689
RefSeq (mRNA)	NM_000389.4	NM_001111099.1
RefSeq (protein)	NP_000380.1	NP_001104569.1
موقعیت (UCSC)	Chr 6: 36.64 – 36.66 Mb	Chr 17: 29.09 – 29.1 Mb
جستجوی پاب‌مد	[۱]	[۲]