الگو:PBB/10062

Nuclear receptor subfamily 1, group H, member 3
PDB rendering based on 1uhl.
ساختارهای موجود بانک داده پروتئین Ortholog search: PDBe, RCSB فهرست کدهای شناسه PDB 1UHL, 3IPQ, 3IPS, 3IPU
شاخص‌ها
نماد ژن	NR1H3; LXR-a; LXRA; RLD-1
شناسه‌های بیرونی	OMIM: 602423 MGI: 1352462 HomoloGene: 21165 IUPHAR: NR1H3 ChEMBL: 2808 GeneCards: NR1H3 Gene
هستی‌شناسی ژن Molecular function • DNA binding • steroid hormone receptor activity • transcription coactivator activity • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity • protein binding • zinc ion binding • cholesterol binding • sterol response element binding • sequence-specific DNA binding • transcription regulatory region DNA binding • retinoid X receptor binding • protein heterodimerization activity Cellular component • nuclear chromatin • nucleus • nucleoplasm • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • insulin receptor signaling pathway • gene expression • negative regulation of macrophage derived foam cell differentiation • positive regulation of triglyceride biosynthetic process • positive regulation of receptor biosynthetic process • positive regulation of cholesterol efflux • negative regulation of cholesterol storage • positive regulation of cellular protein metabolic process • negative regulation of lipid transport • positive regulation of cholesterol transport • response to progesterone stimulus • positive regulation of toll-like receptor 4 signaling pathway • cholesterol homeostasis • regulation of circadian rhythm • negative regulation of macrophage activation • apoptotic cell clearance • cellular lipid metabolic process • positive regulation of fatty acid biosynthetic process • negative regulation of proteolysis • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • negative regulation of pinocytosis • negative regulation of inflammatory response • positive regulation of lipoprotein lipase activity • lipid homeostasis • sterol homeostasis • negative regulation of interferon-gamma-mediated signaling pathway • triglyceride homeostasis • cellular response to lipopolysaccharide • negative regulation of pancreatic juice secretion • negative regulation of secretion of lysosomal enzymes • positive regulation of cholesterol homeostasis Sources: Amigo / QuickGO
الگوی بیان RNA
دادهای بیان مرجع بیشتر
اورتولوگ
گونه‌ها	انسان	موش
آنتره	10062	22259
آنسامبل	ENSG00000025434	ENSMUSG00000002108
UniProt	Q13133	Q9Z0Y9
RefSeq (mRNA)	NM_001130101.2	NM_001177730.1
RefSeq (protein)	NP_001123573.1	NP_001171201.1
موقعیت (UCSC)	Chr 11: 47.27 – 47.29 Mb	Chr 2: 91.18 – 91.2 Mb
جستجوی پاب‌مد	[۱]	[۲]