ازرین

EZR
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4RM8, 4RMA, 4RM9, 1NI2
معین‌کننده‌ها
نام‌های دیگر	EZR, CVIL, CVL, HEL-S-105, VIL2, Ezrin
شناسه‌های بیرونی	OMIM: 123900 MGI: 98931 HomoloGene: 55740 GeneCards: EZR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۷ (موش)
پایان	7,050,183 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein domain specific binding; • GO:0032403 protein-containing complex binding; • cytoskeletal protein binding; • protein kinase A regulatory subunit binding; • protein kinase A catalytic subunit binding; • S100 protein binding; • actin filament binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • cell adhesion molecule binding; • microtubule binding; • ATPase binding; • actin binding; • RNA binding; • cadherin binding; • protein C-terminus binding; • disordered domain specific binding; • protein kinase A binding; • identical protein binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • اندوزوم; • membrane; • focal adhesion; • لولچه عرضی; • ruffle; • Schwann cell microvillus; • ruffle membrane; • actin cytoskeleton; • perinuclear region of cytoplasm; • اسکلت سلولی; • cell projection; • cytoplasmic side of apical plasma membrane; • myelin sheath; • ریزپرز; • microspike; • apical plasma membrane; • لیپید رفت; • extracellular exosome; • microvillus membrane; • ciliary basal body; • filopodium; • cortical cytoskeleton; • پوسته یاخته; • apical part of cell; • astrocyte projection; • intracellular anatomical structure; • cell cortex; • brush border; • ریزرشته; • TCR signalosome; • cell periphery; • cell body; • ریزکیسه; • plasma membrane raft; • uropod; • basolateral plasma membrane; • immunological synapse; • cell tip; • fibrillar center; • extracellular space; • extrinsic component of membrane; • GO:0009327 protein-containing complex;
فرایند زیستی	• leukocyte cell-cell adhesion; • regulation of organelle assembly; • sphingosine-1-phosphate receptor signaling pathway; • negative regulation of p38MAPK cascade; • actin filament bundle assembly; • establishment of epithelial cell apical/basal polarity; • positive regulation of multicellular organism growth; • astral microtubule organization; • cellular response to cAMP; • establishment of endothelial barrier; • microvillus assembly; • negative regulation of T cell receptor signaling pathway; • gland morphogenesis; • cortical microtubule organization; • positive regulation of protein localization to early endosome; • positive regulation of early endosome to late endosome transport; • intestinal D-glucose absorption; • establishment or maintenance of apical/basal cell polarity; • regulation of NIK/NF-kappaB signaling; • epithelial cell differentiation; • regulation of actin cytoskeleton organization; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of protein secretion; • membrane to membrane docking; • regulation of cell shape; • protein kinase A signaling; • establishment of centrosome localization; • phosphatidylinositol-mediated signaling; • regulation of cell size; • actin cytoskeleton reorganization; • filopodium assembly; • receptor internalization; • terminal web assembly; • هدایت آسه; • GO:1901313 positive regulation of gene expression; • negative regulation of ERK1 and ERK2 cascade; • protein localization to cell cortex; • regulation of microvillus length; • protein localization to plasma membrane; • positive regulation of protein localization to plasma membrane;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7430
	22350
	ENSG00000092820
	ENSMUSG00000052397
	P15311
	P26040
	NM_001111077، NM_003379 XM_011536110، NM_001111077، NM_003379
	NM_009510
	NP_003370، XP_011534412 NP_001104547، NP_003370، XP_011534412
	NP_033536
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اِزرین (انگلیسی: Ezrin) که با نام‌های سیتوویلین و ویلین-۲ هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «EZR» کُدگذاری می‌شود.^[۴]

ریشهٔ آمینی این پروتئین حاوی دومِـین FERM و ریشهٔ کربوکسیل آن حاوی دومِـین ERM است. پروتئین‌های غشائی پیرامونی سیتوپلاسم که توسط ژن «EZR» کُدگذاری می‌شوند، توسط تیروزین کیناز در میکروویلی‌ها فسفریله می‌شوند. اِزرین، پیونددهندهٔ غشای سلولی به اسکلت سلولی است و نقش مهمی در اتصال‌های سطحی سلول، حرکت سلول و سازماندهی آنها دارد.^[۵]

اِزرین با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000052397 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. doi:10.1002/j.1460-2075.1989.tb08598.x. PMC 401598. PMID 2591371.
↑ "Entrez Gene: VIL2 villin 2 (ezrin)".
↑ ^۶٫۰ ^۶٫۱ Gajate C, Mollinedo F (March 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. 280 (12): 11641–7. doi:10.1074/jbc.M411781200. PMID 15659383.
↑ Parlato S, Giammarioli AM, Logozzi M, Lozupone F, Matarrese P, Luciani F, Falchi M, Malorni W, Fais S (October 2000). "CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway". EMBO J. 19 (19): 5123–34. doi:10.1093/emboj/19.19.5123. PMC 302100. PMID 11013215.
↑ Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (August 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J. Biol. Chem. 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. PMID 9705328.
↑ Serrador JM, Vicente-Manzanares M, Calvo J, Barreiro O, Montoya MC, Schwartz-Albiez R, Furthmayr H, Lozano F, Sánchez-Madrid F (March 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". J. Biol. Chem. 277 (12): 10400–9. doi:10.1074/jbc.M110694200. PMID 11784723.
↑ Gary R, Bretscher A (August 1995). "Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site". Mol. Biol. Cell. 6 (8): 1061–75. doi:10.1091/mbc.6.8.1061. PMC 301263. PMID 7579708.
↑ Gary R, Bretscher A (November 1993). "Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10846–50. doi:10.1073/pnas.90.22.10846. PMC 47875. PMID 8248180.

مشارکت‌کنندگان ویکی‌پدیا. «Ezrin». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ اکتبر ۲۰۲۱.

برای مطالعهٔ بیشتر[ویرایش]

Martin TA, Harrison G, Mansel RE, Jiang WG (2004). "The role of the CD44/ezrin complex in cancer metastasis". Crit. Rev. Oncol. Hematol. 46 (2): 165–86. doi:10.1016/S1040-8428(02)00172-5. PMID 12711360.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000052397 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2591371-4] Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. doi:10.1002/j.1460-2075.1989.tb08598.x. PMC 401598. PMID 2591371.

[5] "Entrez Gene: VIL2 villin 2 (ezrin)".

[pmid15659383-6] ۶٫۰ ^۶٫۱ Gajate C, Mollinedo F (March 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. 280 (12): 11641–7. doi:10.1074/jbc.M411781200. PMID 15659383.

[pmid11013215-7] Parlato S, Giammarioli AM, Logozzi M, Lozupone F, Matarrese P, Luciani F, Falchi M, Malorni W, Fais S (October 2000). "CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway". EMBO J. 19 (19): 5123–34. doi:10.1093/emboj/19.19.5123. PMC 302100. PMID 11013215.

[pmid9705328-8] Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (August 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J. Biol. Chem. 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. PMID 9705328.

[pmid11784723-9] Serrador JM, Vicente-Manzanares M, Calvo J, Barreiro O, Montoya MC, Schwartz-Albiez R, Furthmayr H, Lozano F, Sánchez-Madrid F (March 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". J. Biol. Chem. 277 (12): 10400–9. doi:10.1074/jbc.M110694200. PMID 11784723.

[pmid7579708-10] Gary R, Bretscher A (August 1995). "Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site". Mol. Biol. Cell. 6 (8): 1061–75. doi:10.1091/mbc.6.8.1061. PMC 301263. PMID 7579708.

[pmid8248180-11] Gary R, Bretscher A (November 1993). "Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10846–50. doi:10.1073/pnas.90.22.10846. PMC 47875. PMID 8248180.

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