SYNJ2BP

SYNJ2BP
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2ENO, 2JIK, 2JIN
معین‌کننده‌ها
نام‌های دیگر	SYNJ2BP, ARIP2, OMP25, synaptojanin 2 binding protein
شناسه‌های بیرونی	OMIM: 609411 MGI: 1344347 HomoloGene: 10161 GeneCards: SYNJ2BP
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۲ (موش)
پایان	81,579,685 bp
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • protein C-terminus binding; • ionotropic glutamate receptor binding;
ترکیبات سلولی	• integral component of membrane; • mitochondrial outer membrane; • membrane; • میتوکندری; • integral component of mitochondrial outer membrane; • ionotropic glutamate receptor complex; • basolateral plasma membrane; • پیوند میان‌یاخته‌ای; • تماس عصبی-ماهیچه‌ای; • neuron projection; • postsynaptic density membrane;
فرایند زیستی	• negative regulation of endothelial cell migration; • negative regulation of angiogenesis; • regulation of Notch signaling pathway; • negative regulation of endothelial cell proliferation; • negative regulation of sprouting angiogenesis; • negative regulation of ERK1 and ERK2 cascade; • protein targeting; • Rho protein signal transduction; • regulation of endocytosis; • intracellular distribution of mitochondria; • chemical synaptic transmission; • receptor clustering; • establishment or maintenance of epithelial cell apical/basal polarity; • receptor localization to synapse; • cell-cell adhesion;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	55333
	24071
	ENSG00000213463
	ENSMUSG00000090935
	P57105
	Q9D6K5
	NM_018373
	NM_001309814، NR_132136، NR_132142 NM_025292، NM_001309814، NR_132136، NR_132142
	NP_060843
	NP_079568 NP_001296743، NP_079568
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین متصل شونده سیناپتوجانین ۲ پروتئینی است که در انسان توسط ژن SYNJ2BP کدگذاری می‌شود.^[۴]^[۵]

فعل و انفعالات[ویرایش]

مشخص شده‌است که SYNJ2BP با پروتئین‌های زیر، تعامل پروتئین-پروتئین دارد:

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000090935 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ ^۴٫۰ ^۴٫۱ ^۴٫۲ Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". The Journal of Biological Chemistry. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
↑ "Entrez Gene: SYNJ2BP synaptojanin 2 binding protein".
↑ Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561.
↑ ^۷٫۰ ^۷٫۱ Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.

جهت مطالعه[ویرایش]

Nemoto Y, De Camilli P (Jun 1999). "Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein". The EMBO Journal. 18 (11): 2991–3006. doi:10.1093/emboj/18.11.2991. PMC 1171381. PMID 10357812.
Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P (Oct 2001). "Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein". The Journal of Cell Biology. 155 (3): 393–404. doi:10.1083/jcb.200012039. PMC 2150840. PMID 11673475.
Lin F, Yu YP, Woods J, Cieply K, Gooding B, Finkelstein P, Dhir R, Krill D, Becich MJ, Michalopoulos G, Finkelstein S, Luo JH (Nov 2001). "Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers". The American Journal of Pathology. 159 (5): 1603–12. doi:10.1016/S0002-9440(10)63006-4. PMC 3277320. PMID 11696420.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000090935 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11882656-4] ۴٫۰ ^۴٫۱ ^۴٫۲ Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". The Journal of Biological Chemistry. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.

[entrez-5] "Entrez Gene: SYNJ2BP synaptojanin 2 binding protein".

[pmid15451561-6] Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561.

[pmid10827173-7] ۷٫۰ ^۷٫۱ Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.

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