DRG1

DRG1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2EKI
معین‌کننده‌ها
نام‌های دیگر	DRG1, NEDD3, developmentally regulated GTP binding protein 1
شناسه‌های بیرونی	OMIM: 603952 MGI: 1343297 HomoloGene: 3060 GeneCards: DRG1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	3,216,415 bp
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • GTP binding; • transcription factor binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • identical protein binding; • GO:0006184 GTPase activity; • microtubule binding; • hydrolase activity; • potassium ion binding; • metal ion binding;
ترکیبات سلولی	• سیتوپلاسم; • پلی‌زوم; • membrane; • سیتوزول; • nuclear body; • هسته یاخته;
فرایند زیستی	• multicellular organism development; • transcription, DNA-templated; • cytoplasmic translation; • positive regulation of microtubule polymerization; • regulation of mitotic spindle assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4733
	13494
	ENSG00000185721
	ENSMUSG00000020457
	Q9Y295
	P32233
	NM_004147
	XM_017314249 NM_007879، XM_017314249
	NP_004138
	XP_017169738 NP_031905، XP_017169738
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین ۱ متصل شونده به GTP با رشد تنظیم شده، پروتئینی است که در انسان توسط ژن DRG1 کدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020457 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi:10.1016/S0021-9258(18)47271-7. PMID 7929244.
↑ Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.
↑ "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

جهت مطالعه[ویرایش]

Sazuka T, Kinoshita M, Tomooka Y, et al. (1992). "Expression of DRG during murine embryonic development". Biochem. Biophys. Res. Commun. 189 (1): 371–7. doi:10.1016/0006-291X(92)91568-B. PMID 1280421.
Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
Zhao XF, Aplan PD (1999). "SCL binds the human homologue of DRG in vivo". Biochim. Biophys. Acta. 1448 (1): 109–14. doi:10.1016/s0167-4889(98)00129-3. PMID 9824680.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta. 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID 10760581.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bandyopadhyay S, Pai SK, Gross SC, et al. (2003). "The Drg-1 gene suppresses tumor metastasis in prostate cancer". Cancer Res. 63 (8): 1731–6. PMID 12702552.
Bandyopadhyay S, Pai SK, Hirota S, et al. (2004). "Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression". Oncogene. 23 (33): 5675–81. doi:10.1038/sj.onc.1207734. PMID 15184886.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bandyopadhyay S, Wang Y, Zhan R, et al. (2007). "The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer". Cancer Res. 66 (24): 11983–90. doi:10.1158/0008-5472.CAN-06-0943. PMID 17178897.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020457 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_7929244-4] Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi:10.1016/S0021-9258(18)47271-7. PMID 7929244.

[pmid_1449490-5] Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.

[entrez-6] "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

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