CLSTN1

CLSTN1
معین‌کننده‌ها
نام‌های دیگر	CLSTN1, ALC-ALPHA, CDHR12, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CST-1, calsyntenin 1
شناسه‌های بیرونی	OMIM: 611321 MGI: 1929895 HomoloGene: 8814 GeneCards: CLSTN1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	149,733,356 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• X11-like protein binding; • calcium ion binding; • amyloid-beta binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • kinesin binding;
ترکیبات سلولی	• integral component of membrane; • postsynaptic membrane; • دستگاه گلژی; • cell projection; • endoplasmic reticulum membrane; • membrane; • Golgi membrane; • پوسته یاخته; • سیناپس; • extracellular region; • cell surface; • پیوند میان‌یاخته‌ای; • شبکه آندوپلاسمی; • هسته یاخته; • GO:0097483، GO:0097481 postsynaptic density; • postsynaptic endosome; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic density membrane; • integral component of spine apparatus membrane;
فرایند زیستی	• چسبندگی سلولی; • positive regulation of synaptic transmission; • regulation of cell growth; • homophilic cell adhesion via plasma membrane adhesion molecules; • positive regulation of synapse assembly; • regulation of synapse maturation; • neurotransmitter receptor transport to postsynaptic membrane; • vesicle-mediated transport in synapse;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	22883
	65945
	ENSG00000171603
	ENSMUSG00000039953
	O94985
	Q9EPL2
	NM_001009566، NM_001302883، XM_047449470 NM_014944، NM_001009566، NM_001302883، XM_047449470
	NM_023051، XM_006539093، XM_006539094، XM_030253692، XM_030253693، XM_036164295 NM_001290989، NM_023051، XM_006539093، XM_006539094، XM_030253692، XM_030253693، XM_036164295
	NP_001289812، NP_055759 NP_001009566، NP_001289812، NP_055759
	NP_075538، XP_006539156، XP_006539157، XP_030109552، XP_030109553، XP_036020188 NP_001277918، NP_075538، XP_006539156، XP_006539157، XP_030109552، XP_030109553، XP_036020188
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

کلسینتنین-1 پروتئینی است که در انسان توسط ژن CLSTN1 کدگذاری می شود.^[۴]^[۵]

اثرات بالینی[ویرایش]

جهش در این ژن با مکانیسم های بیماری‌زای بیماری آلزایمر مرتبط است.^[۶]

فعل و انفعالات[ویرایش]

مشخص شده است که CLSTN1 با APBA2^[۷]^[۸] و پروتئین پیش ساز آمیلوئید تعامل پروتئین-پروتئین دارد.^[۷]^[۸]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000039953 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
↑ "Entrez Gene: CLSTN1 calsyntenin 1".
↑ Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics. 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMC 3373235. PMID 22434822.
↑ ^۷٫۰ ^۷٫۱ Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.
↑ ^۸٫۰ ^۸٫۱ Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.

پیوند به بیرون[ویرایش]

مکان ژنوم CLSTN1 انسانی و صفحهٔ جزئیات ژنی CLSTN1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
مکان ژنوم PIK3CD انسانی و صفحهٔ جزئیات ژنی PIK3CD در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

بیشتر خواندن[ویرایش]

Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, Indermühle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P (Aug 2006). "Calsyntenin-1 docks vesicular cargo to kinesin-1" (PDF). Molecular Biology of the Cell. 17 (8): 3651–63. doi:10.1091/mbc.E06-02-0112. PMC 1525238. PMID 16760430.^{^{[پیوند مرده]}}
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA (Jun 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195. S2CID 36630738.
Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.
Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.
Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (Jan 2001). "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Molecular and Cellular Neurosciences. 17 (1): 151–66. doi:10.1006/mcne.2000.0937. PMID 11161476. S2CID 30856590.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000039953 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-4] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[entrez-5] "Entrez Gene: CLSTN1 calsyntenin 1".

[doi.10.1093/hmg/dds109-6] Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics. 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMC 3373235. PMID 22434822.

[pmid12972431-7] ۷٫۰ ^۷٫۱ Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.

[pmid15037614-8] ۸٫۰ ^۸٫۱ Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.

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