CHMP2A

CHMP2A
معین‌کننده‌ها
نام‌های دیگر	CHMP2A, BC-2, BC2, CHMP2, VPS2, VPS2A, charged multivesicular body protein 2A
شناسه‌های بیرونی	OMIM: 610893 MGI: 1916203 HomoloGene: 6382 GeneCards: CHMP2A
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	12,768,734 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein domain specific binding; • phosphatidylcholine binding; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• سیتوزول; • اندوزوم; • membrane; • late endosome membrane; • membrane coat; • extracellular exosome; • ESCRT III complex; • nuclear envelope; • کروماتین; • multivesicular body;
فرایند زیستی	• regulation of centrosome duplication; • protein polymerization; • viral budding via host ESCRT complex; • protein heterooligomerization; • nucleus organization; • GO:0019067 چرخه زندگی ویروس; • establishment of protein localization; • negative regulation of centriole elongation; • membrane invagination; • multivesicular body assembly; • negative regulation of cell death; • regulation of mitotic spindle assembly; • endosomal transport; • GO:0015915 transport; • protein transport; • positive regulation of exosomal secretion; • septum digestion after cytokinesis; • mitotic metaphase plate congression; • protein homooligomerization; • vacuolar transport; • regulation of viral process; • ESCRT III complex disassembly; • nuclear membrane reassembly; • exit from mitosis; • macroautophagy; • endosome transport via multivesicular body sorting pathway; • late endosome to vacuole transport; • midbody abscission;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	27243
	68953
	ENSG00000130724
	ENSMUSG00000033916
	O43633
	Q9DB34
	NM_014453، NM_198426، XM_005258746 XM_005258747، NM_014453، NM_198426، XM_005258746
	NM_001360730، NM_001360731، NM_001360733، NR_153796 NM_026885، NM_001360730، NM_001360731، NM_001360733، NR_153796
	NP_940818، XP_005258803، XP_005258804 NP_055268، NP_940818، XP_005258803، XP_005258804
	NP_001347659، NP_001347660، NP_001347662 NP_081161، NP_001347659، NP_001347660، NP_001347662
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین 2a بدنه چند وزیکولی باردار پروتئینی است که در انسان توسط ژن CHMP2A کدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000033916 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fujita H, Umezuki Y, Imamura K, Ishikawa D, Uchimura S, Nara A, Yoshimori T, Hayashizaki Y, Kawai J, Ishidoh K, Tanaka Y, Himeno M (Jun 2004). "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J Cell Sci. 117 (Pt 14): 2997–3009. doi:10.1242/jcs.01170. PMID 15173323.
↑ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
↑ "Entrez Gene: CHMP2A chromatin modifying protein 2A".

پیوند به بیرون[ویرایش]

مکان ژنوم CHMP2A انسانی و صفحهٔ جزئیات ژنی CHMP2A در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

جهت مطالعه[ویرایش]

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000033916 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_15173323-4] Fujita H, Umezuki Y, Imamura K, Ishikawa D, Uchimura S, Nara A, Yoshimori T, Hayashizaki Y, Kawai J, Ishidoh K, Tanaka Y, Himeno M (Jun 2004). "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J Cell Sci. 117 (Pt 14): 2997–3009. doi:10.1242/jcs.01170. PMID 15173323.

[pmid_11559748-5] Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.

[entrez-6] "Entrez Gene: CHMP2A chromatin modifying protein 2A".

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