ناقل ۲ متعادل‌کننده نوکلئوزید

SLC29A2
معین‌کننده‌ها
نام‌های دیگر	SLC29A2, DER12, ENT2, HNP36, Equilibrative nucleoside transporter 2, solute carrier family 29 member 2
شناسه‌های بیرونی	OMIM: 602110 MGI: 1345278 HomoloGene: 37493 GeneCards: SLC29A2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۹ (موش)
پایان	5,031,972 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nucleoside transmembrane transporter activity;
ترکیبات سلولی	• integral component of membrane; • پوسته یاخته; • basolateral plasma membrane; • integral component of plasma membrane; • پوشش هسته‌ای; • هستک; • membrane; • هسته یاخته; • presynapse;
فرایند زیستی	• nucleoside transport; • تکثیر سلولی; • nucleoside transmembrane transport; • nucleobase-containing compound metabolic process; • adenine transport; • guanine transport; • uridine transport; • hypoxanthine transport; • thymine transport; • بازجذب;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3177
	13340
	ENSG00000174669
	ENSMUSG00000024891
	Q14542
	Q61672
	NM_001300869، NM_001532، NR_125343، XM_011544974، XM_017017632، XM_017017633، XM_017017636، XM_017017638، XR_001747842، XR_001747844، XR_001747845، XM_024448461، XM_024448462، XM_024448463، XM_024448464، XM_024448465 NM_001300868، NM_001300869، NM_001532، NR_125343، XM_011544974، XM_017017632، XM_017017633، XM_017017636، XM_017017638، XR_001747842، XR_001747844، XR_001747845، XM_024448461، XM_024448462، XM_024448463، XM_024448464، XM_024448465
	XM_006531664، XM_017318055، XM_017318056، XM_017318057 NM_007854، XM_006531664، XM_017318055، XM_017318056، XM_017318057
	NP_001287798، NP_001523، XP_011543276، XP_016873121، XP_016873122، XP_016873125، XP_016873127، XP_024304229، XP_024304230، XP_024304231، XP_024304232، XP_024304233 NP_001287797، NP_001287798، NP_001523، XP_011543276، XP_016873121، XP_016873122، XP_016873125، XP_016873127، XP_024304229، XP_024304230، XP_024304231، XP_024304232، XP_024304233
	XP_006531727، XP_017173544، XP_017173545، XP_017173546 NP_031880، XP_006531727، XP_017173544، XP_017173545، XP_017173546
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

ناقل ۲ متعادل‌کننده نوکلئوزید (انگلیسی: Equilibrative nucleoside transporter 2) یک پروتئین است که در انسان توسط ژن «SLC29A2» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024891 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, Phillips JA III, Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS (Sep 1997). "The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome". Genomics. 42 (2): 325–30. doi:10.1006/geno.1997.4751. PMID 9192854.
↑ Crawford CR, Patel DH, Naeve C, Belt JA (Mar 1998). "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line". J Biol Chem. 273 (9): 5288–93. doi:10.1074/jbc.273.9.5288. PMID 9478986.
↑ "Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2".

مشارکت‌کنندگان ویکی‌پدیا. «Equilibrative nucleoside transporter 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۶ فوریه ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

Baldwin SA, Beal PR, Yao SY, et al. (2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Arch. 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422.
Mangravite LM, Badagnani I, Giacomini KM (2004). "Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney". Eur. J. Pharmacol. 479 (1–3): 269–81. doi:10.1016/j.ejphar.2003.08.076. PMID 14612157.
Williams JB, Lanahan AA (1995). "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein". Biochem. Biophys. Res. Commun. 213 (1): 325–33. doi:10.1006/bbrc.1995.2133. PMID 7639753.
Griffiths M, Yao SY, Abidi F, et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta". Biochem. J. 328 (3): 739–43. doi:10.1042/bj3280739. PMC 1218980. PMID 9396714.
Yao SY, Ng AM, Vickers MF, et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation". J. Biol. Chem. 277 (28): 24938–48. doi:10.1074/jbc.M200966200. PMID 12006583.
Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552.
Ward JL, Leung GP, Toan SV, Tse CM (2003). "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2". Arch. Biochem. Biophys. 411 (1): 19–26. doi:10.1016/S0003-9861(02)00718-X. PMID 12590919.
Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors". Int. J. Cancer. 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Visser F, Zhang J, Raborn RT, et al. (2005). "Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites". Mol. Pharmacol. 67 (4): 1291–8. doi:10.1124/mol.104.005884. PMID 15644498.
Visser F, Baldwin SA, Isaac RE, et al. (2005). "Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters". J. Biol. Chem. 280 (12): 11025–34. doi:10.1074/jbc.M410348200. PMID 15649894.
Owen RP, Lagpacan LL, Taylor TR, et al. (2006). "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2". Drug Metab. Dispos. 34 (1): 12–5. doi:10.1124/dmd.105.006270. PMID 16214850.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024891 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9192854-4] Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, Phillips JA III, Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS (Sep 1997). "The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome". Genomics. 42 (2): 325–30. doi:10.1006/geno.1997.4751. PMID 9192854.

[pmid9478986-5] Crawford CR, Patel DH, Naeve C, Belt JA (Mar 1998). "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line". J Biol Chem. 273 (9): 5288–93. doi:10.1074/jbc.273.9.5288. PMID 9478986.

[entrez-6] "Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2".

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]