SV2A

SV2A
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4V11
معین‌کننده‌ها
نام‌های دیگر	SV2A, SV2, synaptic vesicle glycoprotein 2A
شناسه‌های بیرونی	OMIM: 185860 MGI: 1927139 HomoloGene: 32237 GeneCards: SV2A
موقعیت ژن (موش)
کروموزوم	کروموزوم ۳ (موش)
پایان	96,102,837 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0022891 transmembrane transporter activity; • transporter activity; • protein kinase binding; • signaling receptor activity;
ترکیبات سلولی	• membrane; • synaptic vesicle; • cell-cell junction; • تماس عصبی-ماهیچه‌ای; • پوسته یاخته; • سیناپس; • presynaptic active zone; • پیوند میان‌یاخته‌ای; • شبکه آندوپلاسمی; • GO:0016023 cytoplasmic vesicle; • integral component of membrane; • integral component of synaptic vesicle membrane; • synaptic vesicle membrane; • neuron projection; • دندریت; • neuronal cell body; • glutamatergic synapse; • GABA-ergic synapse;
فرایند زیستی	• cellular calcium ion homeostasis; • transmembrane transport; • neurotransmitter transport; • regulation of gamma-aminobutyric acid secretion; • chemical synaptic transmission; • GO:0072468 ورارسانی پیام; • synaptic vesicle priming;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	9900
	64051
	ENSG00000159164
	ENSMUSG00000038486
	Q7L0J3
	Q9JIS5
	NM_001278719، NM_001328674، NM_001328675 NM_014849، NM_001278719، NM_001328674، NM_001328675
	NM_022030
	NP_001315603، NP_001315604، NP_055664 NP_001265648، NP_001315603، NP_001315604، NP_055664
	NP_071313
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گلیکوپروتئین وزیکولی 2A سیناپسی (انگلیسی: Synaptic vesicle glycoprotein 2A) یک پروتئین است که در انسان توسط ژن «SV2A» کدگذاری می‌شود.^[۴]^[۵]^[۶]

این پروتئین یکی از اهداف دارهای ضد صرع لوتیراستام و بریواراستام است.^[۷]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000038486 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bajjalieh SM, Peterson K, Linial M, Scheller RH (Mar 1993). "Brain contains two forms of synaptic vesicle protein 2". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2150–4. doi:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585.
↑ Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM (Dec 1999). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 15268–73. doi:10.1073/pnas.96.26.15268. PMC 24809. PMID 10611374.
↑ "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A".
↑ Ulloa CM, Towfigh A, Safdieh J (2009). "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatric Disease and Treatment. 5: 467–76. doi:10.2147/ndt.s4844. PMC 2747386. PMID 19777068.

مشارکت‌کنندگان ویکی‌پدیا. «SV2A». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۴ ژوئن ۲۰۱۸.

بیشتر بخوانید[ویرایش]

Bajjalieh SM, Peterson K, Shinghal R, Scheller RH (Aug 1992). "SV2, a brain synaptic vesicle protein homologous to bacterial transporters". Science. 257 (5074): 1271–3. doi:10.1126/science.1519064. PMID 1519064.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS (Jan 2000). "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface". The Journal of Biological Chemistry. 275 (1): 451–60. doi:10.1074/jbc.275.1.451. PMID 10617638.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B (Jun 2004). "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam". Proceedings of the National Academy of Sciences of the United States of America. 101 (26): 9861–6. doi:10.1073/pnas.0308208101. PMC 470764. PMID 15210974.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000038486 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7681585-4] Bajjalieh SM, Peterson K, Linial M, Scheller RH (Mar 1993). "Brain contains two forms of synaptic vesicle protein 2". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2150–4. doi:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585.

[pmid10611374-5] Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM (Dec 1999). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 15268–73. doi:10.1073/pnas.96.26.15268. PMC 24809. PMID 10611374.

[entrez-6] "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A".

[pmid19777068-7] Ulloa CM, Towfigh A, Safdieh J (2009). "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatric Disease and Treatment. 5: 467–76. doi:10.2147/ndt.s4844. PMC 2747386. PMID 19777068.

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