GOT1

GOT1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	3II0, 3WZF
معین‌کننده‌ها
نام‌های دیگر	GOT1, ASTQTL1, GIG18, cAspAT, cCAT, AST1, glutamic-oxaloacetic transaminase 1
شناسه‌های بیرونی	OMIM: 138180 MGI: 95791 HomoloGene: 1571 GeneCards: GOT1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۹ (موش)
پایان	43,513,044 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • L-aspartate:2-oxoglutarate aminotransferase activity; • L-cysteine:2-oxoglutarate aminotransferase activity; • transaminase activity; • catalytic activity; • carboxylic acid binding; • L-phenylalanine:2-oxoglutarate aminotransferase activity; • phosphatidylserine decarboxylase activity; • pyridoxal phosphate binding;
ترکیبات سلولی	• سیتوپلاسم; • axon terminus; • میتوکندری; • کافنده‌تن; • extracellular exosome; • هسته یاخته; • نوکلئوپلاسم; • سیتوزول;
فرایند زیستی	• Notch signaling pathway; • نوگلوکززایی; • dicarboxylic acid metabolic process; • aspartate metabolic process; • aspartate catabolic process; • cellular amino acid metabolic process; • response to glucocorticoid; • cellular amino acid biosynthetic process; • زیست‌ساخت; • 2-oxoglutarate metabolic process; • oxaloacetate metabolic process; • glutamate catabolic process to 2-oxoglutarate; • aspartate biosynthetic process; • fatty acid homeostasis; • cellular response to insulin stimulus; • glutamate catabolic process to aspartate; • glutamate metabolic process; • glycerol biosynthetic process; • response to carbohydrate; • positive regulation of transforming growth factor beta receptor signaling pathway; • negative regulation of collagen biosynthetic process; • response to immobilization stress; • response to cadmium ion; • negative regulation of cytosolic calcium ion concentration; • negative regulation of mitochondrial depolarization; • transdifferentiation; • cellular response to mechanical stimulus; • response to transition metal nanoparticle;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2805
	14718
	ENSG00000120053
	ENSMUSG00000025190
	P17174
	P05201
	NM_002079
	XR_004940117 NM_010324، XR_004940117
	NP_002070
	NP_034454
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

آسپارتات ترانس‌آمیناز، سیتوپلاسمی (انگلیسی: Aspartate aminotransferase, cytoplasmic) یک آنزیم است که در انسان توسط ژن «GOT1» واقع بر کروموزوم ۱۰ کُدگذاری می‌شود.^[۴]^[۵]

این آنزیم در متابولیسم اسیدهای آمینه، چرخه اوره و چرخه اسید سیتریک نقش دارد.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000025190 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bousquet-Lemercier B, Pol S, Pave-Preux M, Hanoune J, Barouki R (Sep 1990). "Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection". Biochemistry. 29 (22): 5293–9. doi:10.1021/bi00474a011. PMID 1974457.
↑ "Entrez Gene: GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)".

مشارکت‌کنندگان ویکی‌پدیا. «GOT1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۱ اکتبر ۲۰۱۸.

بیشتر بخوانید

Panteghini M (1990). "Aspartate aminotransferase isoenzymes". Clin. Biochem. 23 (4): 311–9. doi:10.1016/0009-9120(90)80062-N. PMID 2225456.
Doonan S, Barra D, Bossa F (1985). "Structural and genetic relationships between cytosolic and mitochondrial isoenzymes". Int. J. Biochem. 16 (12): 1193–9. doi:10.1016/0020-711X(84)90216-7. PMID 6397370.
Kamei S, Ohkubo A, Yamanaka M (1979). "Apoenzyme of aspartate aminotransferase isozymes in serum and its diagnostic usefullness for hepatic diseases". Clin. Chim. Acta. 96 (1–2): 97–105. doi:10.1016/0009-8981(79)90058-5. PMID 225064.
Doyle JM, Schininà ME, Bossa F, Doonan S (1990). "The amino acid sequence of cytosolic aspartate aminotransferase from human liver". Biochem. J. 270 (3): 651–7. PMC 1131781. PMID 2241899.
Pol S, Bousquet-Lemercier B, Pavé-Preux M, et al. (1989). "Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization". Hum. Genet. 83 (2): 159–64. doi:10.1007/BF00286710. PMID 2777255.
Pol S, Bousquet-Lemercier B, Pave-Preux M, et al. (1989). "Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA". Biochem. Biophys. Res. Commun. 157 (3): 1309–15. doi:10.1016/S0006-291X(88)81017-9. PMID 3207426.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wang CY, Huang YQ, Shi JD, et al. (1999). "Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene". Am. J. Med. Genet. 84 (5): 454–9. doi:10.1002/(SICI)1096-8628(19990611)84:5<454::AID-AJMG9>3.0.CO;2-D. PMID 10360399.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Miyake Y, Eguchi H, Shinchi K, et al. (2003). "Glucose intolerance and serum aminotransferase activities in Japanese men". J. Hepatol. 38 (1): 18–23. doi:10.1016/S0168-8278(02)00323-9. PMID 12480555.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Wu KL, Lu SN, Changchien CS, et al. (2004). "Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome". Am. J. Trop. Med. Hyg. 71 (2): 125–8. PMID 15306699.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Totan A, Greabu M, Totan C, Spinu T (2006). "Salivary aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase: possible markers in periodontal diseases?". Clin. Chem. Lab. Med. 44 (5): 612–5. doi:10.1515/CCLM.2006.096. PMID 16681433.
Dubern B, Girardet JP, Tounian P (2007). "Insulin resistance and ferritin as major determinants of abnormal serum aminotransferase in severely obese children". International Journal of Pediatric Obesity. 1 (2): 77–82. doi:10.1080/17477160600569594. PMID 17907318.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000025190 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1974457-4] Bousquet-Lemercier B, Pol S, Pave-Preux M, Hanoune J, Barouki R (Sep 1990). "Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection". Biochemistry. 29 (22): 5293–9. doi:10.1021/bi00474a011. PMID 1974457.

[entrez-5] "Entrez Gene: GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)".

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