سپتین ۹

SEPTIN9
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4YQF
معین‌کننده‌ها
نام‌های دیگر	SEPTIN9, AF17q25, MSF, MSF1, NAPB, PNUTL4, SINT1, SeptD1, septin 9, SEPT9
شناسه‌های بیرونی	OMIM: 604061 MGI: 1858222 HomoloGene: 90949 GeneCards: SEPTIN9
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	117,253,151 bp
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • GTP binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0006184 GTPase activity; • cadherin binding; • GO:0032947 molecular adaptor activity;
ترکیبات سلولی	• perinuclear region of cytoplasm; • GO:0035085 ساقه مژکی; • septin complex; • ریزلوله; • اسکلت سلولی; • stress fiber; • actin cytoskeleton; • سیتوپلاسم; • non-motile cilium; • septin ring; • microtubule cytoskeleton;
فرایند زیستی	• تقسیم یاخته; • چرخه یاخته‌ای; • positive regulation of non-motile cilium assembly; • protein heterooligomerization; • cilium assembly; • cytoskeleton-dependent cytokinesis;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10801
	53860
	ENSG00000282302; ENSG00000184640
	ENSMUSG00000059248
	Q9UHD8
	Q80UG5
	NM_001113492، NM_001113493، NM_001113494، NM_001113495، NM_001113496، NM_001293695، NM_001293696، NM_001293697، NM_001293698، NM_006640 NM_001113491، NM_001113492، NM_001113493، NM_001113494، NM_001113495، NM_001113496، NM_001293695، NM_001293696، NM_001293697، NM_001293698، NM_006640
	NM_001113487، NM_001113488، NM_017380، XM_006533744، XM_006533745، XM_006533746، XM_030246153، XM_030246154، XM_036156849 NM_001113486، NM_001113487، NM_001113488، NM_017380، XM_006533744، XM_006533745، XM_006533746، XM_030246153، XM_030246154، XM_036156849
	NP_001106964، NP_001106965، NP_001106966، NP_001106967، NP_001106968، NP_001280624، NP_001280625، NP_001280626، NP_001280627، NP_006631 NP_001106963، NP_001106964، NP_001106965، NP_001106966، NP_001106967، NP_001106968، NP_001280624، NP_001280625، NP_001280626، NP_001280627، NP_006631
	NP_001106959، NP_001106960، NP_059076، XP_006533807، XP_006533808، XP_006533809، XP_030102013، XP_030102014، XP_036012742 NP_001106958، NP_001106959، NP_001106960، NP_059076، XP_006533807، XP_006533808، XP_006533809، XP_030102013، XP_030102014، XP_036012742
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

سپتین ۹ (انگلیسی: SEPT9) یک پروتئین است که در انسان توسط ژن «SEPT9» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

این پروتئین با سپتین ۲^[۷] و سپتین ۷^[۷] تعامل پروتئین-پروتئین دارد.

اهمیت بالینی[ویرایش]

پژوهش‌ها نشان داده‌اند که ناحیهٔ وی۲ (v2) از پروموتر ژن سپتین ۹ در بافت سرطان روده بزرگ متیله می‌شود.^[۸] البته آزمایش تشخیصی سپتین ۹ متیله‌شده در مدفوع جهت پایش سرطان روده بزرگ توصیه نمی‌شود،^[۹] چرا که به‌لحاظ حساسیت و ویژگی مشابه آزمایش مدفوع گایاک یا آزمایش‌های ایمنی‌شناسی مدفوع است و انجام همین‌ها کافی است.^[۹] فقط زمانی که بیماران حاضر به انجام تست‌های رایج مدفوع یا انجام کولونوسکوپی نیستند، انجام تست ردیابی سپتین ۹ متیله‌شده بهتر از دست‌روی‌دست گذاشتن و آزمایش نکردن است.^[۹]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000059248 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Osaka M, Rowley JD, Zeleznik-Le NJ (May 1999). "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6428–33. doi:10.1073/pnas.96.11.6428. PMC 26898. PMID 10339604.
↑ Taki T, Ohnishi H, Shinohara K, Sako M, Bessho F, Yanagisawa M, Hayashi Y (Sep 1999). "AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25)". Cancer Research. 59 (17): 4261–5. PMID 10485469.
↑ "Entrez Gene: SEPT9 septin 9".
↑ ^۷٫۰ ^۷٫۱ Surka MC, Tsang CW, Trimble WS (Oct 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell. 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755.
↑ «نسخه آرشیو شده» (PDF). بایگانی‌شده از اصلی (PDF) در ۳ مارس ۲۰۱۶. دریافت‌شده در ۱۴ اوت ۲۰۲۰.
↑ ^۹٫۰ ^۹٫۱ ^۹٫۲
American Society for Clinical Pathology, "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation, American Society for Clinical Pathology, retrieved August 1, 2013, which cites
- Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, Urban T, Afdhal NH, Jacobson IM, Esteban R, Poordad F, Lawitz EJ, McCone J, Shiffman ML, Galler GW, Lee WM, Reindollar R, King JW, Kwo PY, Ghalib RH, Freilich B, Nyberg LM, Zeuzem S, Poynard T, Vock DM, Pieper KS, Patel K, Tillmann HL, Noviello S, Koury K, Pedicone LD, Brass CA, Albrecht JK, Goldstein DB, McHutchison JG (Jul 2010). "Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus". Gastroenterology. 139 (1): 120–9.e18. doi:10.1053/j.gastro.2010.04.013. PMID 20399780.
- Ahlquist DA, Taylor WR, Mahoney DW, Zou H, Domanico M, Thibodeau SN, Boardman LA, Berger BM, Lidgard GP (Mar 2012). "The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia". Clinical Gastroenterology and Hepatology. 10 (3): 272–7.e1. doi:10.1016/j.cgh.2011.10.008. PMC 3980432. PMID 22019796.

مشارکت‌کنندگان ویکی‌پدیا. «SEPT9». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اوت ۲۰۲۰.

برای مطالعهٔ بیشتر[ویرایش]

Pellegrino JE, George RA, Biegel J, Farlow MR, Gardner K, Caress J, Brown MJ, Rebbeck TR, Bird TD, Chance PF (Dec 1997). "Hereditary neuralgic amyotrophy: evidence for genetic homogeneity and mapping to chromosome 17q25". Human Genetics. 101 (3): 277–83. doi:10.1007/s004390050629. PMID 9439655.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Medina M, Marinescu RC, Overhauser J, Kosik KS (Jan 2000). "Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome". Genomics. 63 (2): 157–64. doi:10.1006/geno.1999.6090. PMID 10673328.
Kalikin LM, Sims HL, Petty EM (Jan 2000). "Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors". Genomics. 63 (2): 165–72. doi:10.1006/geno.1999.6077. PMID 10673329.
Russell SE, McIlhatton MA, Burrows JF, Donaghy PG, Chanduloy S, Petty EM, Kalikin LM, Church SW, McIlroy S, Harkin DP, Keilty GW, Cranston AN, Weissenbach J, Hickey I, Johnston PG (Sep 2000). "Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors". Cancer Research. 60 (17): 4729–34. PMID 10987277.
McIlhatton MA, Burrows JF, Donaghy PG, Chanduloy S, Johnston PG, Russell SE (Sep 2001). "Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3". Oncogene. 20 (41): 5930–9. doi:10.1038/sj.onc.1204752. PMID 11593400.
Yamamoto K, Shibata F, Yamaguchi M, Miura O (Jun 2002). "Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25)". International Journal of Hematology. 75 (5): 503–7. doi:10.1007/BF02982114. PMID 12095151.
Surka MC, Tsang CW, Trimble WS (Oct 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell. 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755.
Nagata K, Kawajiri A, Matsui S, Takagishi M, Shiromizu T, Saitoh N, Izawa I, Kiyono T, Itoh TJ, Hotani H, Inagaki M (May 2003). "Filament formation of MSF-A, a mammalian septin, in human mammary epithelial cells depends on interactions with microtubules". The Journal of Biological Chemistry. 278 (20): 18538–43. doi:10.1074/jbc.M205246200. PMID 12626509.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Nagata K, Asano T, Nozawa Y, Inagaki M (Dec 2004). "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11". The Journal of Biological Chemistry. 279 (53): 55895–904. doi:10.1074/jbc.M406153200. PMID 15485874.
Scott M, Hyland PL, McGregor G, Hillan KJ, Russell SE, Hall PA (Jul 2005). "Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours". Oncogene. 24 (29): 4688–700. doi:10.1038/sj.onc.1208574. PMID 15782116.
Ito H, Iwamoto I, Morishita R, Nozawa Y, Narumiya S, Asano T, Nagata K (Oct 2005). "Possible role of Rho/Rhotekin signaling in mammalian septin organization". Oncogene. 24 (47): 7064–72. doi:10.1038/sj.onc.1208862. PMID 16007136.
Scott M, McCluggage WG, Hillan KJ, Hall PA, Russell SE (Mar 2006). "Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis". International Journal of Cancer. 118 (5): 1325–9. doi:10.1002/ijc.21486. PMID 16161048.
Kuhlenbäumer G, Hannibal MC, Nelis E, Schirmacher A, Verpoorten N, Meuleman J, Watts GD, De Vriendt E, Young P, Stögbauer F, Halfter H, Irobi J, Goossens D, Del-Favero J, Betz BG, Hor H, Kurlemann G, Bird TD, Airaksinen E, Mononen T, Serradell AP, Prats JM, Van Broeckhoven C, De Jonghe P, Timmerman V, Ringelstein EB, Chance PF (Oct 2005). "Mutations in SEPT9 cause hereditary neuralgic amyotrophy". Nature Genetics. 37 (10): 1044–6. doi:10.1038/ng1649. PMID 16186812.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000059248 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10339604-4] Osaka M, Rowley JD, Zeleznik-Le NJ (May 1999). "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6428–33. doi:10.1073/pnas.96.11.6428. PMC 26898. PMID 10339604.

[pmid10485469-5] Taki T, Ohnishi H, Shinohara K, Sako M, Bessho F, Yanagisawa M, Hayashi Y (Sep 1999). "AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25)". Cancer Research. 59 (17): 4261–5. PMID 10485469.

[entrez-6] "Entrez Gene: SEPT9 septin 9".

[pmid12388755-7] ۷٫۰ ^۷٫۱ Surka MC, Tsang CW, Trimble WS (Oct 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell. 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755.

[8] «نسخه آرشیو شده» (PDF). بایگانی‌شده از اصلی (PDF) در ۳ مارس ۲۰۱۶. دریافت‌شده در ۱۴ اوت ۲۰۲۰.

[ASCPfive-9] ۹٫۰ ^۹٫۱ ^۹٫۲ American Society for Clinical Pathology, "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation, American Society for Clinical Pathology, retrieved August 1, 2013, which cites
Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, Urban T, Afdhal NH, Jacobson IM, Esteban R, Poordad F, Lawitz EJ, McCone J, Shiffman ML, Galler GW, Lee WM, Reindollar R, King JW, Kwo PY, Ghalib RH, Freilich B, Nyberg LM, Zeuzem S, Poynard T, Vock DM, Pieper KS, Patel K, Tillmann HL, Noviello S, Koury K, Pedicone LD, Brass CA, Albrecht JK, Goldstein DB, McHutchison JG (Jul 2010). "Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus". Gastroenterology. 139 (1): 120–9.e18. doi:10.1053/j.gastro.2010.04.013. PMID 20399780.

Ahlquist DA, Taylor WR, Mahoney DW, Zou H, Domanico M, Thibodeau SN, Boardman LA, Berger BM, Lidgard GP (Mar 2012). "The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia". Clinical Gastroenterology and Hepatology. 10 (3): 272–7.e1. doi:10.1016/j.cgh.2011.10.008. PMC 3980432. PMID 22019796.

[10] Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, Urban T, Afdhal NH, Jacobson IM, Esteban R, Poordad F, Lawitz EJ, McCone J, Shiffman ML, Galler GW, Lee WM, Reindollar R, King JW, Kwo PY, Ghalib RH, Freilich B, Nyberg LM, Zeuzem S, Poynard T, Vock DM, Pieper KS, Patel K, Tillmann HL, Noviello S, Koury K, Pedicone LD, Brass CA, Albrecht JK, Goldstein DB, McHutchison JG (Jul 2010). "Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus". Gastroenterology. 139 (1): 120–9.e18. doi:10.1053/j.gastro.2010.04.013. PMID 20399780.

[11] Ahlquist DA, Taylor WR, Mahoney DW, Zou H, Domanico M, Thibodeau SN, Boardman LA, Berger BM, Lidgard GP (Mar 2012). "The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia". Clinical Gastroenterology and Hepatology. 10 (3): 272–7.e1. doi:10.1016/j.cgh.2011.10.008. PMC 3980432. PMID 22019796.

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