TRAF2

TRAF2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	3M0D, 1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A
معین‌کننده‌ها
نام‌های دیگر	TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117
شناسه‌های بیرونی	OMIM: 601895 MGI: 101835 HomoloGene: 22520 GeneCards: TRAF2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	25,436,952 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• sphingolipid binding; • lipid binding; • CD40 receptor binding; • mitogen-activated protein kinase kinase kinase binding; • zinc ion binding; • signal transducer activity; • metal ion binding; • GO:0050372 ubiquitin-protein transferase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • identical protein binding; • thioesterase binding; • enzyme binding; • protein phosphatase binding; • protein kinase binding; • ubiquitin protein ligase binding; • transferase activity; • tumor necrosis factor receptor binding; • GO:0032403 protein-containing complex binding;
ترکیبات سلولی	• TRAF2-GSTP1 complex; • AIP1-IRE1 complex; • ubiquitin ligase complex; • vesicle membrane; • cell cortex; • لیپید رفت; • CD40 receptor complex; • cytoplasmic side of plasma membrane; • IRE1-TRAF2-ASK1 complex; • نوکلئوپلاسم; • سیتوپلاسم; • سیتوزول; • GO:0009327 protein-containing complex;
فرایند زیستی	• regulation of apoptotic process; • positive regulation of tumor necrosis factor-mediated signaling pathway; • positive regulation of JUN kinase activity; • negative regulation of glial cell apoptotic process; • regulation of tumor necrosis factor-mediated signaling pathway; • protein K63-linked ubiquitination; • positive regulation of DNA-binding transcription factor activity; • tumor necrosis factor-mediated signaling pathway; • activation of NF-kappaB-inducing kinase activity; • positive regulation of protein homodimerization activity; • response to endoplasmic reticulum stress; • protein homotrimerization; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • positive regulation of I-kappaB phosphorylation; • regulation of JNK cascade; • GO:0044257 protein catabolic process; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of interleukin-2 production; • death-inducing signaling complex assembly; • positive regulation of T cell cytokine production; • protein ubiquitination; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of extrinsic apoptotic signaling pathway; • cellular response to nitric oxide; • regulation of extrinsic apoptotic signaling pathway via death domain receptors; • I-kappaB kinase/NF-kappaB signaling; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • GO:0072468 ورارسانی پیام; • protein autoubiquitination; • negative regulation of neuron death; • programmed necrotic cell death; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • protein deubiquitination; • protein heterooligomerization; • GO:0034622 protein-containing complex assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7186
	22030
	ENSG00000127191
	ENSMUSG00000026942
	Q12933
	P39429
	XM_011518976، XM_011518977، XM_047423828، XM_047423829 NM_021138، XM_011518976، XM_011518977، XM_047423828، XM_047423829
	NM_001290413، XM_006497849، XM_006497850 NM_009422، NM_001290413، XM_006497849، XM_006497850
	XP_011517276، XP_011517278، XP_011517279 NP_066961، XP_011517276، XP_011517278، XP_011517279
	NP_033448، XP_006497912، XP_006497913 NP_001277342، NP_033448، XP_006497912، XP_006497913
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور ۲ مرتبط با گیرندهٔ TNF (انگلیسی: TRAF2) یک پروتئین است که در انسان توسط ژن «TRAF2» کُدگذاری می‌شود.

این پروتئین نقش مهمی در برخی فرایندهای حیاتی درون سلول ایفا می‌کند.

TRAF2 با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

MAP4K2^[۴]
BIRC3^[۵]^[۶]^[۷]^[۸]
CD134^[۹]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026942 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (August 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". J. Biol. Chem. 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. PMID 9712898.
↑ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917.
↑ Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (May 1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. doi:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.
↑ Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (Dec 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
↑ Li X, Yang Y, Ashwell JD (March 2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345–7. doi:10.1038/416345a. PMID 11907583.
↑ Arch RH, Thompson CB (January 1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB". Mol. Cell. Biol. 18 (1): 558–65. PMC 121523. PMID 9418902.

مشارکت‌کنندگان ویکی‌پدیا. «TRAF2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۸ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026942 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9712898-4] Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (August 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". J. Biol. Chem. 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. PMID 9712898.

[pmid10753917-5] Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917.

[pmid8643514-6] Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (May 1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. doi:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.

[pmid9384571-7] Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (Dec 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.

[pmid11907583-8] Li X, Yang Y, Ashwell JD (March 2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345–7. doi:10.1038/416345a. PMID 11907583.

[pmid9418902-9] Arch RH, Thompson CB (January 1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB". Mol. Cell. Biol. 18 (1): 558–65. PMC 121523. PMID 9418902.

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]

[۷]

[۸]

[۹]