ACIN1

ACIN1
معین‌کننده‌ها
نام‌های دیگر	ACIN1, ACINUS, ACN, fSAP152, apoptotic chromatin condensation inducer 1
شناسه‌های بیرونی	OMIM: 604562 MGI: 1891824 HomoloGene: 22853 GeneCards: ACIN1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	54,686,931 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• ATPase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • enzyme binding; • nucleic acid binding; • RNA binding;
ترکیبات سلولی	• nuclear speck; • پوسته یاخته; • exon-exon junction complex; • نوکلئوپلاسم; • هستک; • ASAP complex; • هسته یاخته; • سیتوزول;
فرایند زیستی	• apoptotic chromosome condensation; • mRNA processing; • negative regulation of mRNA splicing, via spliceosome; • پیرایش آران‌ای; • positive regulation of apoptotic process; • positive regulation of monocyte differentiation; • erythrocyte differentiation; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • execution phase of apoptosis;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	22985
	56215
	ENSG00000100813
	ENSMUSG00000022185
	Q9UKV3
	Q9JIX8
	NM_001164815، NM_001164816، NM_001164817، NM_014977، XM_005267415، XM_005267416، XM_005267418، XM_006720081، XM_011536570، XM_024449512، NM_001386863، XM_047431113، XM_047431114، XM_047431115، XM_047431116، XM_047431117، XM_047431118، XM_047431119، XM_047431120 NM_001164814، NM_001164815، NM_001164816، NM_001164817، NM_014977، XM_005267415، XM_005267416، XM_005267418، XM_006720081، XM_011536570، XM_024449512، NM_001386863، XM_047431113، XM_047431114، XM_047431115، XM_047431116، XM_047431117، XM_047431118، XM_047431119، XM_047431120
	NM_001085473، NM_001242605، NM_001242606، NM_019567، NM_023190، XM_006519296، XM_006519297، XM_006519298، XM_006519299، XM_006519300، XM_006519301، XM_006519304، XM_006519308 NM_001085472، NM_001085473، NM_001242605، NM_001242606، NM_019567، NM_023190، XM_006519296، XM_006519297، XM_006519298، XM_006519299، XM_006519300، XM_006519301، XM_006519304، XM_006519308
	NP_001158287، NP_001158288، NP_001158289، NP_055792، XP_005267472، XP_005267473، XP_005267475، XP_006720144، XP_011534872، XP_024305280 NP_001158286، NP_001158287، NP_001158288، NP_001158289، NP_055792، XP_005267472، XP_005267473، XP_005267475، XP_006720144، XP_011534872، XP_024305280
	NP_001078942، NP_001229534، NP_001229535، NP_062513، NP_075679، XP_006519359، XP_006519360، XP_006519364، XP_006519367، XP_006519371، XP_030103753، XP_030103754، XP_030103755، XP_030103756، NP_001361699 NP_001078941، NP_001078942، NP_001229534، NP_001229535، NP_062513، NP_075679، XP_006519359، XP_006519360، XP_006519364، XP_006519367، XP_006519371، XP_030103753، XP_030103754، XP_030103755، XP_030103756، NP_001361699
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

القا کننده تراکم کروماتین آپوپتوز در هسته پروتئینی است که در انسان توسط ژن ACIN1 کدگذاری می شود.^[۴]^[۵]^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022185 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID 10490026.
↑ "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

پیوند به بیرون[ویرایش]

مکان ژنوم ACIN1 انسانی و صفحهٔ جزئیات ژنی ACIN1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

جهت مطالعه[ویرایش]

Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC 2193347. PMID 11208865.
Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages". Blood. 100 (13): 4446–53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC 1276706. PMID 16177823.
Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis". J. Biol. Chem. 281 (18): 12475–84. doi:10.1074/jbc.M509859200. PMID 16537548.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma". Journal of Thoracic Oncology. 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID 17409846.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000022185 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-4] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid10490026-5] Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID 10490026.

[entrez-6] "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]