گیرنده ۱ پلی‌پپتید پانکراسی

NPY4R
معین‌کننده‌ها
نام‌های دیگر	NPY4R, NPY4-R, PP1, PPYR1, Y4, Pancreatic polypeptide receptor 1, neuropeptide Y receptor Y4
شناسه‌های بیرونی	OMIM: 601790 HomoloGene: 116086 GeneCards: NPY4R
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• neuropeptide Y receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • pancreatic polypeptide receptor activity; • peptide hormone binding;
ترکیبات سلولی	• integral component of membrane; • پوسته یاخته; • integral component of plasma membrane; • membrane;
فرایند زیستی	• GO:0072468 ورارسانی پیام; • neuropeptide signaling pathway; • chemical synaptic transmission; • G protein-coupled receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5540
	ن/م
	ENSG00000204174
	ن/م
	P0DQD5; P50391
	ن/م
	NM_005972، XM_011539936، XM_011539937، XM_017016386، XM_017016387، XR_001747124، XR_007061972 NM_001278794، NM_005972، XM_011539936، XM_011539937، XM_017016386، XM_017016387، XR_001747124، XR_007061972
	ن/م
	XP_005277701، XP_006717608، XP_011537416، XP_011537417، XP_016870952، XP_016870953 NP_001265724، XP_005277701، XP_006717608، XP_011537416، XP_011537417، XP_016870952، XP_016870953; NP_005963، XP_011538238، XP_011538239، XP_016871875، XP_016871876، NP_001265724، XP_005277701، XP_006717608، XP_011537417، XP_016870952، XP_016870953 NP_001265723، NP_005963، XP_011538238، XP_011538239، XP_016871875، XP_016871876، NP_001265724، XP_005277701، XP_006717608، XP_011537417، XP_016870952، XP_016870953
	ن/م
	ویکی‌داده
مشاهده/ویرایش انسان

گیرنده ۱ پلی‌پپتید پانکراسی که به عنوان گیرنده نوروپپتید Y نوع ۴ نیز شناخته می‌شود، پروتئینی است که در انسان توسط ژن PPYR1 کدگذاری می‌شود.^[۲]^[۳]

لیگاندهای انتخابی[ویرایش]

آگونیست‌ها[ویرایش]

پلی‌پپتید پانکراسی
نوروپپتید Y (آگونیست درون زاد، غیر انتخابی زیرگروه)
پپتید YY
GR-231,118 (آنتاگونیست مخلوط NPY ₁ / آگونیست NPY ₄، CAS# 158859-98-4)

آنتاگونیست‌ها[ویرایش]

UR-AK49^[۴]

منابع[ویرایش]

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
↑ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".
↑ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.

پیوند به بیرون[ویرایش]

"Neuropeptide Y Receptors: Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

جهت مطالعه[ویرایش]

Keire DA, Bowers CW, Solomon TE, Reeve JR (Feb 2002). "Structure and receptor binding of PYY analogs". Peptides. 23 (2): 305–21. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645. S2CID 7082920.
Balasubramaniam A (Apr 2002). "Clinical potentials of neuropeptide Y family of hormones". American Journal of Surgery. 183 (4): 430–4. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.
Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
Benaim G, Villalobo A (Aug 2002). "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. hdl:10261/79981. PMID 12153558.
Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D (Dec 1995). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY". The Journal of Biological Chemistry. 270 (49): 29123–8. doi:10.1074/jbc.270.49.29123. PMID 7493937.
Bard JA, Walker MW, Branchek TA, Weinshank RL (Nov 1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY". The Journal of Biological Chemistry. 270 (45): 26762–5. doi:10.1074/jbc.270.45.26762. PMID 7592911.
Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–5. Bibcode:1996PNAS...93.4661Y. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.
Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, Antonova O, Sutherland GR, Jenkins NA, Herzog H (Dec 1997). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14". Genomics. 46 (3): 513–5. doi:10.1006/geno.1997.5071. PMID 9441761.
Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.
Smith FD, Oxford GS, Milgram SL (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". The Journal of Biological Chemistry. 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. PMID 10391935.
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164. S2CID 6496567.
Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Molecular and Cellular Biology. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. PMC 99861. PMID 11564868.
Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E (Dec 2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells". The Journal of Clinical Endocrinology and Metabolism. 86 (12): 5956–63. doi:10.1210/jcem.86.12.8091. PMID 11739470.
Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
Wu DY, Tkachuck DC, Roberson RS, Schubach WH (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". The Journal of

Biological Chemistry. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_9417917-2] Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.

[entrez-3] "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".

[pmid_17885919-4] Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.

[۱]

[۲]

[۳]

[۴]