الگو:PBB/1029 - ویکی‌پدیا، دانشنامهٔ آزاد

Cyclin-dependent kinase inhibitor 2A

PDB rendering based on 1a5e.

ساختارهای موجود

Ortholog search: PDBe, RCSB

فهرست کدهای شناسه PDB
1A5E, 1BI7, 1DC2, 2A5E

شاخص‌ها

نماد ژن

CDKN2A; ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16

شناسه‌های بیرونی

OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A Gene

هستی‌شناسی ژن
Molecular function	• p53 binding • DNA binding • sequence-specific DNA binding transcription factor activity • cyclin-dependent protein kinase inhibitor activity • protein binding • transcription factor binding • protein kinase binding • NF-kappaB binding • ubiquitin-protein ligase inhibitor activity • MDM2/MDM4 family protein binding
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • nuclear body • senescence-associated heterochromatin focus • protein complex
Biological process	• cell cycle checkpoint • G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • protein polyubiquitination • mitotic cell cycle • negative regulation of cell-matrix adhesion • apoptotic DNA fragmentation • transcription, DNA-dependent • rRNA processing • negative regulation of protein kinase activity • induction of apoptosis • activation of cysteine-type endopeptidase activity involved in apoptotic process • cell cycle arrest • Ras protein signal transduction • negative regulation of cell proliferation • epidermis development • apoptotic mitochondrial changes • rRNA transcription • regulation of G2/M transition of mitotic cell cycle • negative regulation of cell growth • negative regulation of B cell proliferation • regulation of protein stability • protein destabilization • negative regulation of NF-kappaB transcription factor activity • negative regulation of immature T cell proliferation in thymus • positive regulation of protein sumoylation • negative regulation of mammary gland epithelial cell proliferation • positive regulation of smooth muscle cell apoptotic process • somatic stem cell maintenance • senescence-associated heterochromatin focus assembly • negative regulation of phosphorylation • positive regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of cyclin-dependent protein kinase activity • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • regulation of nucleocytoplasmic transport • regulation of protein export from nucleus • somatic stem cell division • protein stabilization • negative regulation of ubiquitin-protein ligase activity • positive regulation of apoptotic process involved in mammary gland involution • protein K63-linked ubiquitination • positive regulation of cell cycle arrest • cellular senescence • replicative senescence • positive regulation of macrophage apoptotic process • positive regulation of cellular senescence
Sources: Amigo / QuickGO