آئولیس (به یونانی:Αἰολίς؛ لاتین:Aiolís) منطقهای تاریخی شامل بخشهایی از غرب و شمال غرب آسیای صغیر (بیشتر مناطق ساحلی اژه و جزایر نزدیک به ساحل همچون لسبوس) در مناطقی است که دولت-شهرهای آئولی یونان واقع شدهاند. مرزهای شمالی آئولیس به منطقهٔ میسیا، مرزهای جنوبی آن به ایونیا و مرزهای شرقی آن به لودیه میرسید.
Aeolis (Ancient Greek: Αἰολίς, Aiolís), or Aeolia (//; Αἰολία, Aiolía), was an area that comprised the west and northwestern region of Asia Minor, mostly along the coast, and also several offshore islands (particularly Lesbos), where the Aeolian Greek city-states were located. Aeolis incorporated the southern parts of Mysia, and is bounded by it to the north, Ionia to the south, and Lydia to the east.
Aeolis was an ancient district on the western coast of Asia Minor. It extended along the Aegean Sea from the entrance of the Hellespont (now the Dardanelles) south to the Hermus River (now the Gediz River). It was named for the Aeolians, some of whom migrated there from Greece before 1000 BC. Aeolis was, however, an ethnological and linguistic enclave rather than a geographical unit. The district often was considered part of the larger northwest region of Mysia.
By the 8th century BC the Aeolians' twelve most important cities were independent. They formed a league of twelve cities (a Dodecapolis): Cyme (also called Phriconis); Larissa; Neonteichos; Temnus; Cilla; Notion; Aegiroessa; Pitane; Aegae; Myrina; Gryneion; and Smyrna.
The most celebrated of the cities was Smyrna (modern Izmir, Turkey), but in 699 BC, Smyrna became part of an Ionian confederacy. This league or confederation, known as the Ionian League, also called the Panionic League, was formed at the end of the Meliac War in the mid-7th century BC.
Attalus III, the last king of Pergamum, bequeathed Aeolis to the Roman Republic in 133 BC. Shortly afterwards it became part of the Roman province of Asia. At the partition of the Roman Empire (395 AD), Aeolis was assigned to the East Roman (Byzantine) empire and remained largely under Byzantine rule until the early 15th century, when the Ottoman Turks occupied the area.