قوز قرنیه

از ویکی‌پدیا، دانشنامهٔ آزاد
پرش به: ناوبری، جستجو
فارسی English
قوز قرنیه

چشم مبتلا به قوز قرنیه
آی‌سی‌دی-۱۰ H18.6
آی‌سی‌دی-۹ 371.6
اُمیم 148300
دادگان بیماری‌ها 7158
مدلاین پلاس 001013
ای‌مدیسین oph/104


سمت چپ چشم طبیعی؛ سمت راست چشم با قوز قرنیه

کراتوکونوس یا قوز قرنیه (به انگلیسی: Keratoconus)‏ بیماری پیشرونده ای است که معمولا" در سنین نوجوانی یا اوایل دهه سوم زندگی بروز می کند. در این بیماری قرنیه نازک شده و شکل آن تغییر می کند. قرنیه به طور طبیعی شکلی گرد یا کروی دارد ولی در کراتوکونوس (قوز قرنیه) قرنیه برآمده و مخروطی شکل می شود. این مسئله بر روی انکسار نور هنگام ورود به چشم تأثیر گذاشته و سبب کاهش وضوح بینایی می شود. کراتوکونوس ممکن است در یک یا هر دو چشم رخ دهد ولی در۹۰٪ موارد در هر دو چشم دیده می شود.

محتویات

علائم و نشانه‌های کراتوکونوس [ویرایش]

شبیه سازی تصویری که فرد مبتلا به قوز قرنیه مشاده می‌کند

تشخیص کراتوکونوس (قوز قرنیه) ممکن است به دلیل بروز و پیشرفت آهسته آن مشکل باشد. این بیماری ممکن است با نزدیک بینی و آستیگماتیسم همراه باشد در نتیجه ممکن است موجب عدم وضوح و تاری دید شود. بیمار همچنین ممکن است دچار هاله بینی و حساسیت به نور باشد. بیماران معمولا" در هر بار مراجعه به چشم پزشک نسخه شان تغییر می‌کند.

علل قوز قرنیه [ویرایش]

علت کراتوکونوس (قوز قرنیه) مشخص نیست. این بیماری ممکن است ژنتیکی باشد زیرا بیماران متعددی در یک خانواده دیده می شوند.

درمان [ویرایش]

در انواع خفیف بیماری، عینک یا لنز نرم (Soft Contact Lenses) ممکن است کمک کننده باشد ولی با پیشرفت بیماری و نازکتر شدن و تغییر شکل بیشتر قرنیه این درمان‌ها دیگر چندان کارساز نخواهد بود. درمان بعدی بیماری استفاده از لنزهای سخت دارای قابلیت نفوذ گاز است. این لنزها قابلیت بیشتری برای اصلاح آستیگاتیسم نامنظم ناشی از کراتوکونوس (قوز قرنیه) دارند. قرار گیری مناسب لنز بر روی قرنیه مبتلا به کراتوکونوس (قوز قرنیه) کاری ظریف و زمان گیر است. به همین دلیل مراجعات مکرر برای تنظیم لنز و اصلاح نسخه غیر قابل اجتناب است. این فرایند با نازکتر شدن و تغییر شکل بیشتر قرنیه نیاز به تکرار داشته و نسخه بیمار باید مجددا" تغییر داده شود. در صورتی که قرنیه قادر به تحمل لنز سخت نبوده و یا لنز توانایی اصلاح دید بیمار را نداشته باشد قدم بعدی پیوند قرنیه corneal transplant است. در حال حاضر در بیمارانی که قادر به تحمل لنزهای سخت نیستند و از طرفی انجام پیوند قرنیه به دلیل عوارض آن در آنها توصیه نمی شود از روش‌های جدیدتری مانند قرار دادن رینگ‌های داخل قرنیه مثل Intacs و Ferrara استفاده می شود. مطالعه بر روی این روش در چند سال اخیر در جریان بوده و نتایج نشان دهنده بهبود نسبی بیماران است، هر چند نشان داده نشده است که این روش مانع پیشرفت بیماری شود.

مراحل درمان [ویرایش]

به طور كلی درمان قوز قرنيه به پنج مرحله تقسيم مي شود.

در مراحل اوليه بيماري، تجويز عينك توسط چشم پزشك تا حد زيادي باعث اصلاح ديد مي شود البته بايد توجه داشت بيماري ماهيت پيشرونده دارد در نتيجه نمره عينك تجويز شده تغيير خواهد كرد.

با پيشرفت بيماري و افزايش نزديك بينی و آستيگماتيسم نامنظم مرحله ای فرا مي رسد كه ديگر با عينك نمی توان ديد را اصلاح كرد و براي اصلاح ديد بايد از لنزهای تماسی سخت (Hard Contact Lens) استفاده كرد.

يكي ديگر از درمانهاي جراحي , كه براي قوز قرنيه وجود دارد، استفاده از حلقه هاي داخل قرنيه مي باشد كه اين نوع از درمان در بعضي از قوزهای خفيف تا متوسط كه كنتاكت لنز را نمي توانند تحمل كنند، كاربرد دارد. اين حلقه ها با كاهش ميزان آستيگماتيسم نامنظم به بهبود بينايي كمك مي كنند. اما بايد دانست كه ميزان موفقيت در حلقه هاي داخل قرنيه بسيار متغير و از فردي به فرد ديگر متفاوت خواهد بود و در صورت عدم موفقيت درماني، نهايتا بيمار نياز به پيوند قرنيه خواهد داشت. نتايج عمل در بيماران كراتوكونوس (قوز قرنيه) متفاوت است. در اين بيماران قرار دادن رينگ به طور متوسط باعث بهبود دو خط ديد در نيمي از بيماران مي گردد اگر چه ممكن است بعضي بيماران بهبودي چشمگيرتري داشته باشند. در واقع در بيماران قوز قرنيه اين عمل باعث مي شود بيماري كه قبل از عمل با عينك ديد خوبي نداشته است پس از قرار دادن رينگ به دليل كاهش نامنظمي هاي قرنيه با عينك جديد ديد بهتري نسبت به قبل از عمل داشته باشد. در هر بيمار نيز قابل انجام نيست .

يكي از درمان هاي جديد كه در چند سال اخير مطرح شده پيوند متقاطع بين رشته هاي كلاژن قرنيه (Collagen Cross-Linking یا CXL) با استفاده از اشعه ماورابنفش و داروي ريبوفلاوين است. در اين روش پس از برداشتن لايه سلول هاي سطحي (اپيتليوم) قرنیه، به مدت سی دقیقه (هر 3 دقیقه یک بار) قطره ريبوفلاوين1/. درصد در چشم ريخته ميشود و سپس طی مدت سي دقيقه بعدی در چالیکه هر 5 دقیقه یک بار قطره مذکور در چشم چکانده می شود، اشعه اولتراويوله (ماوراء بنفش) به قرنيه تابانده مي شود . اين كار باعث افزايش پيوندهاي متقاطع بين رشته هاي كلاژن قرنيه (مطابق شكل زير) و در نتيجه افزايش استحكام قرنيه ميشود.در بررسي هاي سه تا پنج ساله ديده شده كه پيشرفت بيماري تقريبا در 100% موارد متوقف شده ودر نيمي از موارد قرنيه اندكي مسطح تر شده ويا بيماري كمي (حدود 2.87 ديوپتر) بهبود يافته است. و بينائي اصلاح شده 1.4 خط بهتر شده است. این روش باعث می شود پیوند قرنیه نیاز نباشد و یا به تاخیر بیفتد. در این روش که در حال حاضر جدیدترین روش درمان قوز قرنیه است، بر خلاف سایر روش های درمانی؛ در اکثر موارد نه تنها از پیشرفت بیماری جلوگیری می شود؛ بلکه بینایی فرد با و بدون عینک بهبود یافته و میزان آستیگماتیسم، کاهش قابل ملاحظه ای خواهد داشت. بهترین داوطلبان این روش عبارتند از: بیمارانی که به تازگی برای آنها تشخیص کراتوکونوس داده شده، افراد جوان و میانسالی که بیماری آنها پیشرونده است و همچنین کسانیکه لنز تماسی روی چشمشان خوب فیت نمی شود.

در صورت پيشرفت بيشتر بيماري مرحله اي فرا مي رسد كه ديگر استفاده از لنزهاي تماسي و قطعات رينگ داخل قرنيه هم باعث افزايش ديد نمي شود و در اثر كدورت قرنيه, استفاده از لنزهاي تماسي ممكن نيست و عدم تحمل نسبت به لنز تماسي پيدا مي شود. در اين مرحله بايد از پيوند قرنيه كمك گرفته شود.

آيا قوز قرنيه باعث کوری می شود؟ [ویرایش]

خوشبختانه اين بيماری كور كننده نيست ولي يكي از علل شايع پيوند قرنيه است فرد مبتلا به قوز قرنيه و يا بستگان وی نبايد نگران باشند زيرا بيماري بي خطر است و عمل پيوند قرنيه نتايج موفقيت آميزي دارد.

آيا قوز قرنيه با ليزر درمان مي شود؟ [ویرایش]

تا کنون عنوان می شد که در بيماراني كه قوز قرنيه دارند به هيچ وجه نبايد اعمال جراحي ليزري مانند ليزيك – لازك يا PRK انجام داد؛ زيرا باعث بدتر شدن بيماري مي شد. اما با ظهور روش (Collagen Cross-Linking یا CXL) می توان بصورت همزمان و یا در قدم بعدی عیب انکساری چشم (شماره چشم) را با لیزر (معمولاPRK) درمان کرد.

منابع [ویرایش]

جستجو در ویکی‌انبار در ویکی‌انبار پرونده‌هایی دربارهٔ قوز قرنیه موجود است.

Keratoconus
Classification and external resources

The "conical cornea" that is characteristic of keratoconus
ICD-10 H18.6
ICD-9 371.6
OMIM 148300
DiseasesDB 7158
MedlinePlus 001013
eMedicine oph/104

Keratoconus (from Greek: kerato- horn, cornea; and konos cone) is a degenerative disorder of the eye in which structural changes within the cornea cause it to thin and change to a more conical shape than its normal gradual curve.

Keratoconus can cause substantial distortion of vision, with multiple images, streaking and sensitivity to light all often reported by the patient. It is typically diagnosed in the patient's adolescent years. If afflicting both eyes, the deterioration in vision can affect the patient's ability to drive a car or read normal print.

In most cases, corrective lenses fitted by a specialist are effective enough to allow the patient to continue to drive legally and likewise function normally. Further progression of the disease may require surgery, for which several options are available, including intrastromal corneal ring segments, cross-linking, mini asymmetric radial keratotomy and, in 25% of cases, corneal transplantation.

Estimates of the prevalence for keratoconus range from 1 in 500 to 1 in 2000 people,[1] but difficulties with differential diagnosis cause uncertainty as to its prevalence. It seems to occur in populations throughout the world, although it is observed more frequently in certain ethnic groups, such as South Asians. Environmental and genetic factors are considered possible causes, but the exact cause is uncertain. It has been associated with detrimental enzyme activity within the cornea, and is more common in patients with Down syndrome.

Contents

Signs and symptoms [edit]

A simulation of the multiple images seen by a person with keratoconus.
"... a candle, when looked at, appears like a number of lights, confusedly running into one another" — Nottingham[2]

People with early keratoconus typically notice a minor blurring of their vision and come to their clinician seeking corrective lenses for reading or driving.[3][4] At early stages, the symptoms of keratoconus may be no different from those of any other refractive defect of the eye. As the disease progresses, vision deteriorates, sometimes rapidly. Visual acuity becomes impaired at all distances, and night vision is often poor. Some individuals have vision in one eye that is markedly worse than that in the other. The disease is often bilateral, though asymmetrical. Some develop photophobia (sensitivity to bright light), eye strain from squinting in order to read, or itching in the eye,[3] but there is normally little or no sensation of pain. It may, in certain cases cause luminous objects appear like cylindrical pipes with the same luminous intensity at all points.

A representation of the multiple images made by extremely high contrast light sources as seen by a person with keratoconus. From left to right: A light source as seen by a healthy eye, uncorrected keratoconus vision, mostly corrected keratoconus vision with contact lenses.

The classic symptom of keratoconus is the perception of multiple "ghost" images, known as monocular polyopia. This effect is most clearly seen with a high contrast field, such as a point of light on a dark background. Instead of seeing just one point, a person with keratoconus sees many images of the point, spread out in a chaotic pattern. This pattern does not typically change from day to day, but over time, it often takes on new forms. Patients also commonly notice streaking and flaring distortion around light sources. Some even notice the images moving relative to one another in time with their heart beat. The predominant optical aberration of the eye in keratoconus is the so-called coma.[5][6] The visual distortion experienced by the patient comes from two sources, one being the irregular deformation of the surface of the cornea, and the other being scarring that occurs on its exposed highpoints. These factors act to form regions on the cornea that map an image to different locations on the retina. The effect can worsen in low light conditions, as the dark-adapted pupil dilates to expose more of the irregular surface of the cornea.

Diagnosis [edit]

A schematic digram showing change in cornea

Prior to any physical examination, the diagnosis of keratoconus frequently begins with an ophthalmologist's or optometrist's assessment of the patient's medical history, particularly the chief complaint and other visual symptoms, the presence of any history of ocular disease or injury which might affect vision, and the presence of any family history of ocular disease. An eye chart, such as a standard Snellen chart of progressively smaller letters, is then used to determine the patient's visual acuity. The eye examination may proceed to measurement of the localized curvature of the cornea with a manual keratometer,[7] with detection of irregular astigmatism suggesting a possibility of keratoconus. Severe cases can exceed the instrument's measuring ability.[4] A further indication can be provided by retinoscopy, in which a light beam is focused on the patient's retina and the reflection, or reflex, observed as the examiner tilts the light source back and forth. Keratoconus is amongst the ophthalmic conditions that exhibit a scissor reflex action of two bands moving toward and away from each other like the blades of a pair of scissors.[4][8]

If keratoconus is suspected, the ophthalmologist or optometrist will search for other characteristic findings of the disease by means of slit lamp examination of the cornea.[9] An advanced case is usually readily apparent to the examiner, and can provide for an unambiguous diagnosis prior to more specialized testing. Under close examination, a ring of yellow-brown to olive-green pigmentation known as a Fleischer ring can be observed in around half of keratoconic eyes.[10] The Fleischer ring, caused by deposition of the iron oxide hemosiderin within the corneal epithelium, is subtle and may not be readily detectable in all cases, but becomes more evident when viewed under a cobalt blue filter.[4] Similarly, around 50% of subjects exhibit Vogt's striae, fine stress lines within the cornea caused by stretching and thinning.[10] The striae temporarily disappear while slight pressure is applied to the eyeball.[4] A highly pronounced cone can create a V-shaped indentation in the lower eyelid when the patient's gaze is directed downwards, known as Munson's sign.[3] Other clinical signs of keratoconus will normally have presented themselves long before Munson's sign becomes apparent,[11] and so this finding, though a classic sign of the disease, tends not to be of primary diagnostic importance.

Corneal topogram of a keratoconic eye

A handheld keratoscope, sometimes known as "Placido's disk", can provide a simple noninvasive visualization of the surface of the cornea by projecting a series of concentric rings of light onto the cornea. A more definitive diagnosis can be obtained using corneal topography, in which an automated instrument projects the illuminated pattern onto the cornea and determines its topology from analysis of the digital image. The topographical map indicates any distortions or scarring in the cornea, with keratoconus revealed by a characteristic steepening of curvature which is usually below the centreline of the eye.[12] The technique can record a snapshot of the degree and extent of the deformation as a benchmark for assessing its rate of progression. It is of particular value in detecting the disorder in its early stages when other signs have not yet presented.[13]

Once keratoconus has been diagnosed, its degree may be classified by several metrics:[14]

  • The steepness of greatest curvature from 'mild' (< 45 D), 'advanced' (up to 52 D) or 'severe' (> 52 D);
  • The morphology of the cone: 'nipple' (small: 5 mm and near-central), 'oval' (larger, below-center and often sagging), or 'globus' (more than 75% of cornea affected);
  • The corneal thickness from mild (> 506 μm) to advanced (< 446 μm).

Increasing use of corneal topography has led to a decline in use of these terms.[14]

Pathophysiology [edit]

A specimen of keratoconic cornea taken out six years after diagnosis: thin stroma, wrinkled posterior surface

Despite considerable research, the etiology of keratoconus remains unclear.[12] Several sources suggest that keratoconus likely arises from a number of different factors: genetic, environmental or cellular, any of which may form the trigger for the onset of the disease.[15][16] Once initiated, the disease normally develops by progressive dissolution of Bowman's layer,[4] which lies between the corneal epithelium and stroma. As the two come into contact, cellular and structural changes in the cornea adversely affect its integrity and lead to the bulging and scarring characteristic of the disorder. Within any individual keratoconic cornea, regions of degenerative thinning coexisting with regions undergoing wound healing may be found. Scarring appears to be an aspect of the corneal degradation; however, a recent, large, multicenter study suggests abrasion by contact lenses may increase the likelihood of this finding by a factor over two.[17]

A number of studies have indicated keratoconic corneas show signs of increased activity by proteases,[15] a class of enzymes that break some of the collagen cross-linkages in the stroma, with a simultaneous reduced expression of protease inhibitors.[18] Other studies have suggested that reduced activity by the enzyme aldehyde dehydrogenase may be responsible for a build-up of free radicals and oxidising species in the cornea.[19] Whatever the pathogenetical process, the damage caused by activity within the cornea likely results in a reduction in its thickness and biomechanical strength. While keratoconus is considered a noninflammatory disorder, one study shows wearing rigid contact lenses by patients leads to overexpression of proinflammatory cytokines, such as IL-6, TNF-alpha, ICAM-1, and VCAM-1 in the tear fluid.[20]

A genetic predisposition to keratoconus has been observed,[21] with the disease running in certain families,[22] and incidences reported of concordance in identical twins.[9] The frequency of occurrence in close family members is not clearly defined, though it is known to be considerably higher than that in the general population,[12] and studies have obtained estimates ranging between 6% and 19%.[23] Two studies involving isolated, largely homogenetic communities have contrarily mapped putative gene locations to chromosomes 16q and 20q.[23] Most genetic studies agree on an autosomal dominant model of inheritance.[3] A rare, autosomal dominant form of severe keratoconus with anterior polar cataract is caused by a mutation in the seed region of mir-184, a microRNA that is highly expressed in the cornea and anterior lens.[24] Keratoconus is diagnosed more often in people with Down's syndrome, though the reasons for this link have not yet been determined.[25]

Keratoconus has been associated with atopic diseases,[26] which include asthma, allergies, and eczema, and it is not uncommon for several or all of these diseases to affect one person. Keratoconus is also associated with Down syndrome and Marfan syndrome.[26] A number of studies suggest vigorous eye rubbing contributes to the progression of keratoconus, and patients should be discouraged from the practice.[27][28][29][30][31][32] Iatrogenic keratoconus has also been observed following LASIK surgery, caused by removal of excessive stromal bed tissue.[33]

Treatment [edit]

Contact lenses [edit]

Main article: Contact lens
Rigid, gas-permeable lens for keratoconus

In early stages of keratoconus, spectacles or soft contact lenses can suffice to correct for the mild astigmatism. As the condition progresses, these may no longer provide the patient with a satisfactory degree of visual acuity, and most clinical practitioners will move to manage the condition with rigid contact lenses, known as rigid, gas-permeable, (RGP) lenses. RGP lenses provide a good level of visual correction, but do not arrest progression of the condition.[34]

In keratoconic patients, rigid contact lenses improve vision by means of tear fluid filling the gap between the irregular corneal surface and the smooth regular inner surface of the lens, thereby creating the effect of a smoother cornea. Many specialized types of contact lenses have been developed for keratoconus, and affected people may seek out both doctors specialized in conditions of the cornea, and contact lens fitters who have experience managing patients with keratoconus. The irregular cone presents a challenge[15] and the fitter will endeavor to produce a lens with the optimal contact, stability and steepness. Some trial-and-error fitting may prove necessary.[11]

Traditionally, contact lenses for keratoconus have been the 'hard' or RGP variety, although manufacturers have also produced specialized 'soft' or hydrophilic lenses and, most recently, silicone hydrogel lenses. A soft lens has a tendency to conform to the conical shape of the cornea, thus diminishing its effect. To counter this, hybrid lenses have been developed which are hard in the centre and encompassed by a soft skirt. However, soft or earlier generation hybrid lenses did not prove effective for every patient.[35] Early generation lenses like SoftPerm have been discontinued.[36] The fourth generation of hybrid lens technology has improved significantly, giving more patients an option that combines the comfort of a soft lens with the visual acuity of an RGP lens.[37] The new generation of technology fixes the issues prevalent in earlier generations and allows contact lenses to be fitted for the majority of patients.[38]

Some patients also find good vision correction and comfort with a "piggyback" lens combination, in which RGP lenses are worn over soft lenses, both providing a degree of vision correction.[39] One form of piggyback lens makes use of a soft lens with a countersunk central area to accept the rigid lens. Fitting a piggyback lens combination requires experience on the part of the lens fitter, and tolerance on the part of the keratoconic patient.

Scleral lenses are sometimes prescribed for cases of advanced or very irregular keratoconus; these lenses cover a greater proportion of the surface of the eye and hence can offer improved stability.[40] The larger size of the lenses may make them unappealing or uncomfortable to some; however, their easier handling can find favor with patients with reduced dexterity, such as the elderly.

Mini sclerals have been available for a few years are a hybrid between a conventional RGP lens and a full scleral and just vault over the cornea into the limbus region. Light in weight, high in oxygen permeability and easy maintenance makes this an option for cases where a patients condition has advanced beyond specialized soft lens. An example is SoClear

Surgical options [edit]

Corneal transplant [edit]

Main article: Cornea transplant
Corneal transplant for keratoconus, approximately one week after surgery - multiple light reflections indicate folds in the cornea which later resolved.

Between 11% and 27% of cases of keratoconus[16][41][42] will progress to a point where vision correction is no longer possible, thinning of the cornea becomes excessive, or scarring as a result of contact lens wear causes problems of its own, and a corneal transplantation or penetrating keratoplasty becomes required. Keratoconus is the most common grounds for conducting a penetrating keratoplasty, generally accounting for around a quarter of such procedures.[43] The corneal transplant surgeon trephines a lenticule of corneal tissue and then grafts the donor cornea to the existing eye tissue, usually using a combination of running and individual sutures. The cornea does not have a direct blood supply, so the donor tissue is not required to be blood type matched. Eye banks check the donor corneas for any disease or cellular irregularities.

Spanish-born eye surgeon Ramon Castroviejo successfully performed keratoplasty as early as 1936.

The acute recovery period can take four to six weeks, and full postoperative vision stabilization often takes a year or more, but most transplants are very stable in the long term.[42] The National Keratoconus Foundation reports that penetrating keratoplasty has the most successful outcome of all transplant procedures, and when performed for keratoconus in an otherwise healthy eye, its success rate can be 95% or greater.[16] The sutures used usually dissolve over a period of three to five years, but individual sutures can be removed during the healing process if they are causing irritation to the patient.

In the USA, corneal transplants (also known as corneal grafts) for keratoconus are usually performed under sedation as outpatient surgery. In other countries, such as Australia and the UK, the operation is commonly performed with the patient undergoing a general anaesthetic. All cases require a careful follow-up with an eye doctor (ophthalmologist or optometrist) for a number of years. Frequently, vision is greatly improved after the surgery, but even if the actual visual acuity does not improve, because the cornea is a more normal shape after the healing is completed, patients can more easily be fitted with corrective lenses. Complications of corneal transplants are mostly related to vascularization of the corneal tissue and rejection of the donor cornea. Vision loss is very rare, though difficult-to-correct vision is possible. When rejection is severe, repeat transplants are often attempted, and are frequently successful.[44] Keratoconus will not normally reoccur in the transplanted cornea; incidences of this have been observed, but are usually attributed to incomplete excision of the original cornea or inadequate screening of the donor tissue.[45] The long-term outlook for corneal transplants performed for keratoconus is usually favorable once the initial healing period is completed and a few years have elapsed without problems.

Corneal ring segment inserts [edit]

Main article: Intrastromal corneal ring segments

A recent surgical alternative to corneal transplant is the insertion of intrastromal corneal ring segments. A small incision is made in the periphery of the cornea and two thin arcs of polymethyl methacrylate are slid between the layers of the stroma on either side of the pupil before the incision is closed.[46] The segments push out against the curvature of the cornea, flattening the peak of the cone and returning it to a more natural shape. The procedure, carried out on an outpatient basis under local anaesthesia, offers the benefit of being reversible and even potentially exchangeable as it involves no removal of eye tissue.[46]

The principal intrastromal ring available is known by the trade name Intacs. Internationally, Ferrara rings are also available. Intacs are a patented technology and are placed outside the optical zone, whereas the smaller prismatic Ferrara rings are placed just inside the 5 mm optical zone. Intacs are the only corneal implants to have gone through the FDA Phase I, II and III clinical trials and were first approved by the Food and Drug Administration (FDA) in the United States in 1999 for myopia; this was extended to the treatment of keratoconus in July 2004.[47]

A pair of Intacs after insertion into the cornea

Clinical studies on the effectiveness of intrastromal rings on keratoconus are in their early stages, and results have so far been generally encouraging,[48][49] though they have yet to enter into wide acceptance with the refractive surgery community. In common with penetrating keratoplasty, the requirement for some vision correction in the form of spectacles or hydrophilic contact lenses may remain subsequent to the operation. Potential complications of intrastromal rings include accidental penetration through to the anterior chamber when forming the channel, postoperative infection of the cornea, and migration or extrusion of the segments.[49] The rings offer a good chance of vision improvement even in otherwise hard-to-manage eyes, but results are not guaranteed and in a few cases may worsen.

Early studies on intrastromal corneal rings involved use of two segments to cause global flattening of the cornea.[50] A later study reported better results could be obtained for those cones located more to the periphery of the cornea by using a single Intacs segment. This leads to preferential flattening of the cone below, but also to steepening the over-flat upper part of the cornea.[51]

Cross-linking [edit]

Main article: Cross-linking (surgery)
Removed corneal epithelium during CCR operation on an eye with post-LASIK complication, from Kymionis et al., 2009[52]

Corneal collagen crosslinking with riboflavin, also known as CXL, CCR, CCL and KXL, involves a one-time application of riboflavin solution to the eye that is activated by illumination with UV-A light for approximately 30 minutes.[18][53] The riboflavin causes new bonds to form across adjacent collagen strands in the stromal layer of the cornea, which recovers and preserves some of the cornea's mechanical strength. The corneal epithelial layer is generally removed to increase penetration of the riboflavin into the stroma.

Clinical trials began in Germany and Italy in 2002, and cross-linking has shown success in retarding or stopping progression of the disease.[54] Results from an Australian study published in 2008 showed stabilization in all treated eyes, and a slight correction in visual acuity in most patients.[55] The procedure, with epithelium removed, is approved for use throughout Europe, and commenced clinical trials in the USA in 2008.[56] By 2010, over 300 patients were treated in the United States in those trials, which are composed of two randomized, controlled, multisite clinical trials for the treatment of progressive keratoconus and post LASIK ectasia.[57]

In some cases, collagen cross-linking may also be combined with other treatments to improve corneal asymmetry or optical refraction. Successful treatment methods include corneal ring segment inserts (Intacs or Ferrara rings),[58] Topography Guided Laser,[54] or Keraflex.[59][60] Corrective lenses are normally required after these treatments, but with smaller, more normalized prescriptions. Increased corneal symmetry allows for more comfortable contact lens wear, often of daily disposable lenses. These newer methods may have an important role in limiting deterioration of vision, increasing unaided and uncorrected vision, and reducing the case for corneal transplantation.[61] [62]

Radial keratotomy [edit]

Main article: Radial keratotomy

Radial keratotomy is a refractive surgery procedure developed by Russian ophtalmologist Svyatoslav Fyodorov in 1974, where the surgeon makes a spoke-like pattern of incisions into the cornea to modify its shape. This early surgical option for myopia has been largely superseded by LASIK and other similar procedures. LASIK is absolutely contraindicated in keratoconus and other corneal thinning conditions as removal of corneal stromal tissue will further damage an already thin and weak cornea.[63]

For similar reasons, radial keratotomy has also generally not been used for keratoconic patients.[64][65]

Mini asymmetric radial keratotomy [edit]

Main article: Mini asymmetric radial keratotomy

The mini asymmetric radial keratotomy is a surgical technique developed by Italian ophthalmologist Marco Abbondanza in 1994 and improved in 2005. It consists of a series of micro-incisions, always made with a diamond knife, designed to cause a controlled scarring of the cornea, which changes its thickness and shape. This procedure, if done properly, is able to correct astigmatism and cure the first and second stage of keratoconus, avoiding the need for a cornea transplant.[66][67][68][69]The Mini Asymmetric Radial Keratotomy can also be used in combination with the cross-linking (also known as CXL, CCR, CCL and KXL), parasurgical treatment for keratoconus.[70][71]

DALK transplants [edit]

One way of reducing the risk of rejection is to use a technique called deep anterior lamellar keratoplasty (DALK). In a DALK graft, only the outermost epithelium and the main bulk of the cornea, the stroma, are replaced; the patient's rearmost endothelium layer and the Descemet's membrane are left, giving some additional structural integrity to the postgraft cornea.[72] Furthermore, it is possible to transplant freeze-dried donor tissue. The freeze-drying process ensures this tissue is dead, so there is no chance of rejection.[72]

Some surgeons prefer to remove the donor epithelium; others leave it in place. Removing it can cause a slight improvement in overall vision, but a corresponding increase in visual recovery time.

Epikeratophakia [edit]

Rarely, a nonpenetrating keratoplasty known as an epikeratophakia (or epikeratoplasty) may be performed in cases of keratoconus. The corneal epithelium is removed and a lenticule of donor cornea is grafted on top of it.[15] The procedure requires a greater level of skill on the part of the surgeon, and is less frequently performed than a penetrating keratoplasty, as the outcome is generally less favorable. However, it may be seen as an option in a number of cases, particularly for young patients.[73]

Prognosis [edit]

A small rupture of Descemet's membrane (magnified view) ...

Patients with keratoconus typically present initially with mild astigmatism and myopia, commonly at the onset of puberty, and are diagnosed by the late teenage years or early 20s. The disease can, however, present or progress at any age; in rare cases, keratoconus can present in children or not until later adulthood.[4] A diagnosis of the disease at an early age may indicate a greater risk of severity in later life.[12][74] Patients' vision will seem to fluctuate over a period of months, driving them to change lens prescriptions frequently, but as the condition worsens, contact lenses are required in the majority of cases. The course of the disorder can be quite variable, with some patients remaining stable for years or indefinitely, while others progress rapidly or experience occasional exacerbations over a long and otherwise steady course. Most commonly, keratoconus progresses for a period of 10 to 20 years[11] before the course of the disease generally ceases in the third and fourth decades of life.

... leads to corneal hydrops.

In advanced cases, bulging of the cornea can result in a localized rupture of Descemet's membrane, an inner layer of the cornea. Aqueous humor from the eye's anterior chamber seeps into the cornea before Descemet's membrane reseals. The patient experiences pain and a sudden severe clouding of vision, with the cornea taking on a translucent milky-white appearance known as a corneal hydrops.[75] Although disconcerting to the patient, the effect is normally temporary and after a period of six to eight weeks, the cornea usually returns to its former transparency. The recovery can be aided nonsurgically by bandaging with an osmotic saline solution. Although a hydrops usually causes increased scarring of the cornea, occasionally it will benefit a patient by creating a flatter cone, aiding the fitting of contact lenses.[75] Occasionally, the cornea thins to the point where a partial rupture occurs at the level of Descemet's membrane, resulting in a small, bead-like swelling on the cornea that may become filled with fluid (cornea hydropsy). When this occurs, severe vision decrease may occur until the edema slowly resolves. Corneal transplantation is not usually indicated while the hydropsy persists.

Epidemiology [edit]

The National Eye Institute reports keratoconus is the most common corneal dystrophy in the United States, affecting about one in 2,000 Americans,[76][77] but some reports place the figure as high as one in 500.[78] The inconsistency may be due to variations in diagnostic criteria,[4] with some cases of severe astigmatism interpreted as those of keratoconus, and vice versa.[11] A long-term study found a mean incidence rate of 2.0 new cases per 100,000 population per year.[77] Some studies have suggested a higher prevalence amongst females,[79] or that people of South Asian ethnicity are 4.4 times as likely to suffer from keratoconus as Caucasians, and are also more likely to be affected with the condition earlier.[80]

Keratoconus is normally bilateral[77] (affecting both eyes) although the distortion is usually asymmetric and is rarely completely identical in both corneas.[4] Unilateral cases tend to be uncommon, and may in fact be very rare if a very mild condition in the better eye is simply below the limit of clinical detection.[11] It is common for keratoconus to be diagnosed first in one eye and not until later in the other. As the condition then progresses in both eyes, the vision in the earlier-diagnosed eye will often remain poorer than that in its fellow.

History [edit]

Practical observations on conical cornea, Nottingham's ground-breaking text on keratoconus, 1854

The German oculist Burchard Mauchart provided an early description in a 1748 doctoral dissertation of a case of keratoconus,[12] which he called staphyloma diaphanum. However, it was not until 1854 that British physician John Nottingham clearly described keratoconus and distinguished it from other ectasias of the cornea.[12] Nottingham reported the cases of "conical cornea" that had come to his attention, and described several classic features of the disease, including polyopia, weakness of the cornea, and difficulty matching corrective lenses to the patient's vision.[2] In 1859, British surgeon William Bowman used an ophthalmoscope (recently invented by Hermann von Helmholtz) to diagnose keratoconus, and described how to angle the instrument's mirror so as to best see the conical shape of the cornea.[81] Bowman also attempted to restore vision by pulling on the iris with a fine hook inserted through the cornea and stretching the pupil into a vertical slit, like that of a cat. He reported that he had had a measure of success with the technique, restoring vision to an 18-year old woman who had previously been unable to count fingers at a distance of 8 inches (20 cm). By 1869, when the pioneering Swiss ophthalmologist Johann Horner wrote a thesis entitled On the treatment of keratoconus,[82] the disorder had acquired its current name. The treatment at that time, endorsed by the leading German ophthalmologist Albrecht von Graefe, was an attempt to physically reshape the cornea by chemical cauterization with a silver nitrate solution and application of a miosis-causing agent with a pressure dressing.[12] In 1888, the treatment of keratoconus became one of the first practical applications of the then newly invented contact lens, when the French physician Eugène Kalt manufactured a glass scleral shell that improved vision by compressing the cornea into a more regular shape.[83] Since the start of the 20th century, research on keratoconus has both improved understanding of the disease and greatly expanded the range of treatment options. The first successful corneal transplantation to treat keratoconus was done in 1936 by Ramon Castroviejo.[84][85]

Related disorders [edit]

Several other noninflammatory eye disorders, generally rarer than keratoconus, also cause thinning of the cornea:[11]

  • Keratoglobus is a very rare condition that causes corneal thinning primarily at the margins, resulting in a spherical, slightly enlarged eye. It may be genetically related to keratoconus.[15]
  • Pellucid marginal degeneration causes thinning of a narrow (1–2 mm) band of the cornea, usually along the inferior corneal margin. It causes irregular astigmatism that, in the early stages of the disease can be corrected by spectacles. Differential diagnosis may be made by slit-lamp examination.[9][86]
  • Posterior keratoconus, a distinct disorder despite its similar name, is a rare abnormality, usually congenital, which causes a nonprogressive thinning of the inner surface of the cornea, while the curvature of the anterior surface remains normal. Usually only a single eye is affected.[15]

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External links [edit]

Wikimedia Commons has media related to: Keratoconus
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